ENSMUSG00000015714


Mus musculus

Features
Gene ID: ENSMUSG00000015714
  
Biological name :Cers2
  
Synonyms : Ceramide synthase 2 / Cers2 / Q924Z4
  
Possible biological names infered from orthology : Q96G23
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.1
Gene start: 95314791
Gene end: 95323599
  
Corresponding Affymetrix probe sets: 10494227 (MoGene1.0st)   1423955_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015858
Ensembl peptide - ENSMUSP00000122672
Ensembl peptide - ENSMUSP00000121110
Ensembl peptide - ENSMUSP00000120190
NCBI entrez gene - 76893     See in Manteia.
MGI - MGI:1924143
RefSeq - XM_006502260
RefSeq - NM_001320492
RefSeq - NM_029789
RefSeq Peptide - NP_001307421
RefSeq Peptide - NP_084065
swissprot - Q924Z4
swissprot - D3Z4M2
swissprot - D3YTM0
swissprot - D3Z0Z2
Ensembl - ENSMUSG00000015714
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cers2aENSDARG00000013704Danio rerio
 cers2bENSDARG00000058992Danio rerio
 CERS2ENSGALG00000039141Gallus gallus
 CERS2ENSG00000143418Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cers3 / Q1A3B0 / Ceramide synthase 3 / Q8IU89*ENSMUSG0000003051050
Cers4 / Q9D6J1 / Ceramide synthase 4 / Q9HA82*ENSMUSG0000000820642
Cers5 / Q9D6K9 / Ceramide synthase 5 / Q8N5B7*ENSMUSG0000002302140
Cers6 / Q8C172 / Ceramide synthase 6 / Q6ZMG9*ENSMUSG0000002703539


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR006634  TRAM/LAG1/CLN8 homology domain
 IPR009057  Homeobox-like domain superfamily
 IPR016439  Sphingosine N-acyltransferase Lag1/Lac1-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0030148 sphingolipid biosynthetic process IDA
 biological_processGO:0046513 ceramide biosynthetic process IDA
 biological_processGO:0048681 negative regulation of axon regeneration IEA
 biological_processGO:1900148 negative regulation of Schwann cell migration IEA
 biological_processGO:1905045 negative regulation of Schwann cell proliferation involved in axon regeneration IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0050291 sphingosine N-acyltransferase activity IDA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Tg(Ppp1r2-cre)4127Nkza/0
Genetic Background: involves: C57BL/6N

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Tg(Ppp1r2-cre)4127Nkza/0
Genetic Background: involves: C57BL/6N

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Tg(Ppp1r2-cre)4127Nkza/0
Genetic Background: involves: C57BL/6N

 MP:0003005 abnormal hippocampal fimbria "malformations in the flattened band of efferent fibers arising from the subiculum and medial border of the hippocampus, which then thickens to form the fornix and fibers of the hippocampal commissure" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Tg(Ppp1r2-cre)4127Nkza/0
Genetic Background: involves: C57BL/6N

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Tg(Ppp1r2-cre)4127Nkza/0
Genetic Background: involves: C57BL/6N

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Tg(Ppp1r2-cre)4127Nkza/0
Genetic Background: involves: C57BL/6N

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Tg(Ppp1r2-cre)4127Nkza/0
Genetic Background: involves: C57BL/6N

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Tg(Ppp1r2-cre)4127Nkza/0
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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