ENSG00000143418


Homo sapiens

Features
Gene ID: ENSG00000143418
  
Biological name :CERS2
  
Synonyms : ceramide synthase 2 / CERS2 / Q96G23
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q21.3
Gene start: 150960583
Gene end: 150975004
  
Corresponding Affymetrix probe sets: 222212_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000454160
Ensembl peptide - ENSP00000452810
Ensembl peptide - ENSP00000453297
Ensembl peptide - ENSP00000271688
Ensembl peptide - ENSP00000355020
Ensembl peptide - ENSP00000357945
Ensembl peptide - ENSP00000357950
Ensembl peptide - ENSP00000393239
Ensembl peptide - ENSP00000394012
NCBI entrez gene - 29956     See in Manteia.
OMIM - 606920
RefSeq - XM_011509452
RefSeq - NM_022075
RefSeq - NM_181746
RefSeq - XM_011509451
RefSeq Peptide - NP_859530
RefSeq Peptide - NP_071358
swissprot - Q5SZE2
swissprot - Q5SZE3
swissprot - Q5SZE4
swissprot - H0YLQ6
swissprot - H0YNU7
swissprot - H0YKH6
swissprot - Q96G23
swissprot - Q5SZE1
Ensembl - ENSG00000143418
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cers2aENSDARG00000013704Danio rerio
 cers2bENSDARG00000058992Danio rerio
 CERS2ENSGALG00000039141Gallus gallus
 Cers2ENSMUSG00000015714Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CERS3 / Q8IU89 / ceramide synthase 3ENSG0000015422751
CERS4 / Q9HA82 / ceramide synthase 4ENSG0000009066148
CERS5 / Q8N5B7 / ceramide synthase 5ENSG0000013962442
CERS6 / Q6ZMG9 / ceramide synthase 6ENSG0000017229241


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR006634  TRAM/LAG1/CLN8 homology domain
 IPR009057  Homeobox-like domain superfamily
 IPR016439  Sphingosine N-acyltransferase Lag1/Lac1-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0030148 sphingolipid biosynthetic process IEA
 biological_processGO:0046513 ceramide biosynthetic process IEA
 biological_processGO:0048681 negative regulation of axon regeneration IEA
 biological_processGO:1900148 negative regulation of Schwann cell migration IEA
 biological_processGO:1905045 negative regulation of Schwann cell proliferation involved in axon regeneration IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0050291 sphingosine N-acyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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