ENSMUSG00000023021


Mus musculus

Features
Gene ID: ENSMUSG00000023021
  
Biological name :Cers5
  
Synonyms : Ceramide synthase 5 / Cers5 / Q9D6K9
  
Possible biological names infered from orthology : Q8N5B7
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F1
Gene start: 99734881
Gene end: 99772885
  
Corresponding Affymetrix probe sets: 10432527 (MoGene1.0st)   1447308_at (Mouse Genome 430 2.0 Array)   1451209_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134845
Ensembl peptide - ENSMUSP00000135723
Ensembl peptide - ENSMUSP00000023762
Ensembl peptide - ENSMUSP00000104663
Ensembl peptide - ENSMUSP00000134988
Ensembl peptide - ENSMUSP00000135074
NCBI entrez gene - 71949     See in Manteia.
MGI - MGI:1919199
RefSeq - NM_028015
RefSeq Peptide - NP_082291
swissprot - Q9D6K9
swissprot - H3BJ49
swissprot - H3BJH5
swissprot - H3BJQ0
swissprot - H3BLB3
Ensembl - ENSMUSG00000023021
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cers5ENSDARG00000002365Danio rerio
 CERS5ENSGALG00000039734Gallus gallus
 CERS5ENSG00000139624Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cers6 / Q8C172 / Ceramide synthase 6 / Q6ZMG9*ENSMUSG0000002703557
Cers3 / Q1A3B0 / Ceramide synthase 3 / Q8IU89*ENSMUSG0000003051037
Cers2 / Q924Z4 / Ceramide synthase 2 / Q96G23*ENSMUSG0000001571437
Cers4 / Q9D6J1 / Ceramide synthase 4 / Q9HA82*ENSMUSG0000000820636


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR006634  TRAM/LAG1/CLN8 homology domain
 IPR009057  Homeobox-like domain superfamily
 IPR016439  Sphingosine N-acyltransferase Lag1/Lac1-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006665 sphingolipid metabolic process IEA
 biological_processGO:0030148 sphingolipid biosynthetic process IDA
 biological_processGO:0046513 ceramide biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0050291 sphingosine N-acyltransferase activity ISO


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr