ENSMUSG00000027035


Mus musculus

Features
Gene ID: ENSMUSG00000027035
  
Biological name :Cers6
  
Synonyms : Ceramide synthase 6 / Cers6 / Q8C172
  
Possible biological names infered from orthology : Q6ZMG9
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C2
Gene start: 68861441
Gene end: 69114282
  
Corresponding Affymetrix probe sets: 10472501 (MoGene1.0st)   1434418_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028426
Ensembl peptide - ENSMUSP00000135604
NCBI entrez gene - 241447     See in Manteia.
MGI - MGI:2442564
RefSeq - XM_017318074
RefSeq - NM_172856
RefSeq - XM_006499452
RefSeq Peptide - NP_766444
RefSeq Peptide - NP_001334090
swissprot - Q8C172
swissprot - H3BL08
Ensembl - ENSMUSG00000027035
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cers6ENSDARG00000053583Danio rerio
 CERS6ENSGALG00000010902Gallus gallus
 CERS6ENSG00000172292Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cers5 / Q9D6K9 / Ceramide synthase 5 / Q8N5B7*ENSMUSG0000002302160
Cers3 / Q1A3B0 / Ceramide synthase 3 / Q8IU89*ENSMUSG0000003051040
Cers4 / Q9D6J1 / Ceramide synthase 4 / Q9HA82*ENSMUSG0000000820639
Cers2 / Q924Z4 / Ceramide synthase 2 / Q96G23*ENSMUSG0000001571438


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR006634  TRAM/LAG1/CLN8 homology domain
 IPR009057  Homeobox-like domain superfamily
 IPR016439  Sphingosine N-acyltransferase Lag1/Lac1-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0030148 sphingolipid biosynthetic process IDA
 biological_processGO:0046513 ceramide biosynthetic process IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0050291 sphingosine N-acyltransferase activity IDA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Arem1Liuy/Y
Genetic Background: involves: C57BL/6J * CBA

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Arem1Liuy/Y
Genetic Background: involves: C57BL/6J * CBA

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Arem1Liuy/Y
Genetic Background: involves: C57BL/6J * CBA

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arem1Liuy/Y
Genetic Background: involves: C57BL/6J * CBA

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr5a2tm3.1Sjns/Nr5a2tm3.1Sjns
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arem1Liuy/Y
Genetic Background: involves: C57BL/6J * CBA

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arem1Liuy/Y
Genetic Background: involves: C57BL/6J * CBA

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr5a2tm3.1Sjns/Nr5a2tm3.1Sjns
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr5a2tm3.1Sjns/Nr5a2tm3.1Sjns
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr5a2tm3.1Sjns/Nr5a2tm3.1Sjns
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N

Allelic Composition: Cers6tm1Arte/Cers6tm1Arte,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr5a2tm3.1Sjns/Nr5a2tm3.1Sjns
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N

Allelic Composition: Cers6tm1Arte/Cers6tm1Arte,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr5a2tm3.1Sjns/Nr5a2tm3.1Sjns
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N

 MP:0008034 enhanced lipolysis "increase in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr5a2tm3.1Sjns/Nr5a2tm3.1Sjns
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N

 MP:0008912 nervous "increased, skittish, behavior induced by stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arem1Liuy/Y
Genetic Background: involves: C57BL/6J * CBA

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arem1Liuy/Y
Genetic Background: involves: C57BL/6J * CBA

 MP:0009125 decreased brown fat cell lipid droplet size "reduction in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr5a2tm3.1Sjns/Nr5a2tm3.1Sjns
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N

 MP:0009269 decreased fat cell size "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr5a2tm3.1Sjns/Nr5a2tm3.1Sjns
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr5a2tm3.1Sjns/Nr5a2tm3.1Sjns
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr5a2tm3.1Sjns/Nr5a2tm3.1Sjns
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N

 MP:0011620 abnormal habituation to a new environment "anomaly in the process in which there is a progressive decline of behavioral response probability with an exposure to a new environment" [MGI:csmith]
Show

Allelic Composition: Arem1Liuy/Y
Genetic Background: involves: C57BL/6J * CBA

 MP:0012232 abnormal ceramide level 
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr5a2tm3.1Sjns/Nr5a2tm3.1Sjns
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N

Allelic Composition: Cers6tm1Arte/Cers6tm1Arte,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0014171 increased fatty acid oxidation "increased rate or incidence of the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen" [GO:0019395]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr5a2tm3.1Sjns/Nr5a2tm3.1Sjns
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr