ENSMUSG00000010025


Mus musculus

Features
Gene ID: ENSMUSG00000010025
  
Biological name :Aldh3a2
  
Synonyms : Aldh3a2 / Fatty aldehyde dehydrogenase / P47740
  
Possible biological names infered from orthology : aldehyde dehydrogenase 3 family member A2 / P51648
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B2
Gene start: 61223417
Gene end: 61267464
  
Corresponding Affymetrix probe sets: 10386652 (MoGene1.0st)   1415776_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000073764
Ensembl peptide - ENSMUSP00000147199
Ensembl peptide - ENSMUSP00000104355
Ensembl peptide - ENSMUSP00000067767
NCBI entrez gene - 11671     See in Manteia.
MGI - MGI:1353452
RefSeq - XM_006532029
RefSeq - XM_006532030
RefSeq - XM_006532031
RefSeq - XM_006532032
RefSeq - NM_007437
RefSeq Peptide - NP_031463
swissprot - P47740
swissprot - B1ATI0
swissprot - A0A140LJF9
swissprot - B1AV77
Ensembl - ENSMUSG00000010025
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aldh3a1ENSDARG00000074791Danio rerio
 aldh3a2aENSDARG00000028259Danio rerio
 aldh3a2bENSDARG00000029381Danio rerio
 P51648ENSG00000072210Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P47739 / Aldh3a1 / Mus musculus aldehyde dehydrogenase family 3, subfamily A1 (Aldh3a1), transcript variant 3, mRNA. / P30838* / aldehyde dehydrogenase 3 family member A1*ENSMUSG0000001910260
Q80VQ0 / Aldh3b1 / Aldehyde dehydrogenase family 3 member B1 / P43353* / aldehyde dehydrogenase 3 family member B1*ENSMUSG0000002488550
J3QMK6 / Aldh3b3 / Aldehyde dehydrogenase family 3 member B3 / P48448* / ALDH3B2* / aldehyde dehydrogenase 3 family member B2*ENSMUSG0000003726350
E9Q3E1 / Aldh3b2 / Aldehyde dehydrogenase family 3 member B2 / P48448* / aldehyde dehydrogenase 3 family member B2*ENSMUSG0000007529649


Protein motifs (from Interpro)
Interpro ID Name
 IPR012394  Aldehyde dehydrogenase NAD(P)-dependent
 IPR015590  Aldehyde dehydrogenase domain
 IPR016160  Aldehyde dehydrogenase, cysteine active site
 IPR016161  Aldehyde/histidinol dehydrogenase
 IPR016162  Aldehyde dehydrogenase, N-terminal
 IPR029510  Aldehyde dehydrogenase, glutamic acid active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006081 cellular aldehyde metabolic process IEA
 biological_processGO:0006714 sesquiterpenoid metabolic process ISO
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0007422 peripheral nervous system development IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008544 epidermis development IEA
 biological_processGO:0033306 phytol metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005777 peroxisome ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004029 aldehyde dehydrogenase (NAD) activity ISO
 molecular_functionGO:0004030 aldehyde dehydrogenase [NAD(P)+] activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0046577 long-chain-alcohol oxidase activity IEA
 molecular_functionGO:0050061 long-chain-aldehyde dehydrogenase activity ISO
 molecular_functionGO:0052814 medium-chain-aldehyde dehydrogenase activity ISO


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis
Alpha-oxidation of phytanate


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gas8Gt(CH0760)Wtsi/Gas8em1Bky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001236 abnormal spinous layer morphology "structual or developmental anomaly of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gas8Gt(CH0760)Wtsi/Gas8em1Bky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gas8Gt(CH0760)Wtsi/Gas8em1Bky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0003453 abnormal keratinocyte physiology "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860]
Show

Allelic Composition: Gas8Gt(CH0760)Wtsi/Gas8em1Bky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gas8Gt(CH0760)Wtsi/Gas8em1Bky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004777 abnormal phospholipid level "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gas8Gt(CH0760)Wtsi/Gas8em1Bky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0009441 delayed skin barrier formation "slowed progression in the establishment of the ability of the skin to regulate water loss" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gas8Gt(CH0760)Wtsi/Gas8em1Bky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gas8Gt(CH0760)Wtsi/Gas8em1Bky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Gas8Gt(CH0760)Wtsi/Gas8em1Bky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013245 abnormal lipid metabolism "any anomaly in the chemical reactions and pathways involving a lipid, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
Show

Allelic Composition: Gas8Gt(CH0760)Wtsi/Gas8em1Bky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020016 decreased aldehyde dehydrogenase activity "increased ability to catalyze the oxidation (dehydrogenation) of aldehydes." [GOC:NV, http://en.wikipedia.org/wiki/Aldehyde_dehydrogenase]
Show

Allelic Composition: Gas8Gt(CH0760)Wtsi/Gas8em1Bky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000010025 P47740 / Aldh3a2 / Fatty aldehyde dehydrogenase / P51648* / aldehyde dehydrogenase 3 family member A2*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr