ENSMUSG00000010097


Mus musculus

Features
Gene ID: ENSMUSG00000010097
  
Biological name :Nxf1
  
Synonyms : Nuclear RNA export factor 1 / Nxf1 / Q99JX7 / Q9CQE2
  
Possible biological names infered from orthology : Q9UBU9
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 8757073
Gene end: 8772475
  
Corresponding Affymetrix probe sets: 10461191 (MoGene1.0st)   10461214 (MoGene1.0st)   1416628_at (Mouse Genome 430 2.0 Array)   1416791_a_at (Mouse Genome 430 2.0 Array)   1439092_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139229
Ensembl peptide - ENSMUSP00000139351
Ensembl peptide - ENSMUSP00000010241
Ensembl peptide - ENSMUSP00000010248
Ensembl peptide - ENSMUSP00000139050
Ensembl peptide - ENSMUSP00000139090
Ensembl peptide - ENSMUSP00000139124
NCBI entrez gene - 66836     See in Manteia.
NCBI entrez gene - 53319     See in Manteia.
MGI - MGI:1858330
RefSeq - NM_016813
RefSeq - NM_001276704
RefSeq - NM_025791
RefSeq Peptide - NP_001263633
RefSeq Peptide - NP_058093
RefSeq Peptide - NP_080067
swissprot - Q99JX7
swissprot - Q9CQE2
swissprot - V9GX96
swissprot - V9GXC8
swissprot - V9GXF3
swissprot - V9GXM5
swissprot - V9GXW3
Ensembl - ENSMUSG00000010097
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nxf1ENSDARG00000055076Danio rerio
 zgc:153681ENSDARG00000086017Danio rerio
 NXF1ENSG00000162231Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nxf7 / NXF2* / NXF5* / NXF2B* / Q9GZY0* / Q9H1B4* / nuclear RNA export factor 5* / nuclear RNA export factor 2* / nuclear RNA export factor 2B*ENSMUSG0000003141046
Nxf2 / NXF5* / NXF2B* / Q9GZY0* / Q9H1B4* / nuclear RNA export factor 2* / nuclear RNA export factor 5* / nuclear RNA export factor 2B*ENSMUSG0000000994146
Nxf3 / Q9H4D5* / nuclear RNA export factor 3*ENSMUSG0000005700035


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR002075  Nuclear transport factor 2
 IPR005637  TAP C-terminal (TAP-C) domain
 IPR009060  UBA-like superfamily
 IPR015245  Nuclear RNA export factor Tap, RNA-binding domain
 IPR018222  Nuclear transport factor 2, eukaryote
 IPR026100  Transmembrane protein 223
 IPR030217  Nuclear RNA export factor
 IPR032675  Leucine-rich repeat domain superfamily
 IPR032710  NTF2-like domain superfamily
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006405 RNA export from nucleus IDA
 biological_processGO:0006406 mRNA export from nucleus IEA
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0016973 poly(A)+ mRNA export from nucleus IPI
 biological_processGO:0051028 mRNA transport IEA
 cellular_componentGO:0000346 transcription export complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005643 nuclear pore IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0042405 nuclear inclusion body IDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Transport of Mature mRNA derived from an Intron-Containing Transcript


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nxf1Mvb1/Nxf1Mvb1,Pitpnavb/Pitpnavb
Genetic Background: involves: C3HeB/Fe * C57BL/6J * CAST/Ei * DBA/2J

Allelic Composition: Ap3d1mh-2J/Ap3d1mh-2J,Nxf1Mvb1/Nxf1Mvb1
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Nxf1Mvb1/Nxf1Mvb1,Usp14ax-J/Usp14ax-J
Genetic Background: involves: C57BL/6

Allelic Composition: Nxf1em1Haml/Nxf1+,Pitpnavb/Pitpnavb
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Nxf1em1Haml/Nxf1Mvb1,Pitpnavb/Pitpnavb
Genetic Background: involves: C57BL/6 * DBA/2J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Atcayji-hes/Atcayji-hes,Nxf1Mvb1/Nxf1Mvb1
Genetic Background: involves: C3H/HeJ * C57BL/6

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Thratm1Syc/Thra+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
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Allelic Composition: Eya1bor/Eya1bor,Nxf1Mvb1/Nxf1Mvb1
Genetic Background: involves: C3HeB/FeJ * C57BL/6J * CAST/Ei

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Map1btm1Rak/Map1b+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: E2f4tm1Jrn/E2f4tm1Jrn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002855 abnormal cochlear ganglion morphology "malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Eya1bor/Eya1bor,Nxf1Mvb1/Nxf1Mvb1
Genetic Background: involves: C3HeB/FeJ * C57BL/6J * CAST/Ei

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Nxf1Mvb1/Nxf1Mvb1,Pitpnavb/Pitpnavb
Genetic Background: involves: C57BL/6J * CAST/Ei * DBA/2J

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atcayji-hes/Atcayji-hes,Nxf1Mvb1/Nxf1Mvb1
Genetic Background: involves: C3H/HeJ * C57BL/6

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nxf1em1Haml/Nxf1+,Pitpnavb/Pitpnavb
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Nxf1em1Haml/Nxf1Mvb1,Pitpnavb/Pitpnavb
Genetic Background: involves: C57BL/6 * DBA/2J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Eya1bor/Eya1bor,Nxf1Mvb1/Nxf1Mvb1
Genetic Background: involves: C3HeB/FeJ * C57BL/6J * CAST/Ei

Allelic Composition: Eya1bor/Eya1bor,Nxf1Mvb1/Nxf1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J * CAST/Ei

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000036992 Nxt1 / Q9QZV9 / NTF2-related export protein 1 / Q9UKK6* / nuclear transport factor 2 like export factor 1*  / complex






 

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