ENSMUSG00000009941


Mus musculus

Features
Gene ID: ENSMUSG00000009941
  
Biological name :Nxf2
  
Synonyms : Nxf2
  
Possible biological names infered from orthology : nuclear RNA export factor 2 / nuclear RNA export factor 2B / nuclear RNA export factor 5 / NXF2B / NXF5 / Q9GZY0 / Q9H1B4
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: E3
Gene start: 134944526
Gene end: 134964754
  
Corresponding Affymetrix probe sets: 10606746 (MoGene1.0st)   1420585_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000010085
Ensembl peptide - ENSMUSP00000108812
Ensembl peptide - ENSMUSP00000108814
NCBI entrez gene - 83454     See in Manteia.
MGI - MGI:1933192
RefSeq - XM_011247765
RefSeq - NM_001289735
RefSeq - NM_001289736
RefSeq - NM_031259
RefSeq Peptide - NP_001276665
RefSeq Peptide - NP_112549
RefSeq Peptide - NP_001276664
swissprot - Q4ZGD8
swissprot - Q8R499
swissprot - Q99MW6
Ensembl - ENSMUSG00000009941
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nxf1ENSDARG00000055076Danio rerio
 zgc:153681ENSDARG00000086017Danio rerio
 NXF2ENSG00000269405Homo sapiens
 NXF2BENSG00000269437Homo sapiens
 NXF5ENSG00000126952Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nxf7 / NXF2* / NXF5* / NXF2B* / Q9GZY0* / Q9H1B4* / nuclear RNA export factor 5* / nuclear RNA export factor 2* / nuclear RNA export factor 2B*ENSMUSG0000003141043
Nxf1 / Q99JX7 / Q9CQE2 / Nuclear RNA export factor 1 / Q9UBU9*ENSMUSG0000001009741
Nxf3 / Q9H4D5* / nuclear RNA export factor 3*ENSMUSG0000005700030


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR002075  Nuclear transport factor 2
 IPR005637  TAP C-terminal (TAP-C) domain
 IPR009060  UBA-like superfamily
 IPR015245  Nuclear RNA export factor Tap, RNA-binding domain
 IPR018222  Nuclear transport factor 2, eukaryote
 IPR030217  Nuclear RNA export factor
 IPR032675  Leucine-rich repeat domain superfamily
 IPR032710  NTF2-like domain superfamily
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006405 RNA export from nucleus ISO
 biological_processGO:0006406 mRNA export from nucleus IEA
 biological_processGO:0016973 poly(A)+ mRNA export from nucleus IPI
 biological_processGO:0051028 mRNA transport IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005635 nuclear envelope ISO
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding ISO
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Transport of Mature mRNA derived from an Intron-Containing Transcript


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Nxf2tm1.1Jw Nxf3tm1.1Jw/Y,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Nxf2tm1.2Jw/Y
Genetic Background: B6.Cg-Nxf2tm1.2Jw

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Nxf2tm1.1Jw Nxf3tm1.1Jw/Y,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Hsf4tm1Xyk/Hsf4tm1Xyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Nxf2tm1.2Jw/Y
Genetic Background: B6.Cg-Nxf2tm1.2Jw

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Hsf4tm1Xyk/Hsf4tm1Xyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nxf2tm1.2Jw/Y
Genetic Background: B6.Cg-Nxf2tm1.2Jw

Allelic Composition: Nxf2tm1.1Jw Nxf3tm1.1Jw/Y,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hsf4tm1Xyk/Hsf4tm1Xyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nxf2tm1.2Jw/Y
Genetic Background: B6.Cg-Nxf2tm1.2Jw

 MP:0002685 abnormal proliferation of spermatogonia "reduction in the proliferation of the spermatogonial stem cells either due to reduced mitosis or increased apoptosis" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62271]
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Allelic Composition: Nxf2tm1.2Jw/Y
Genetic Background: B6.Cg-Nxf2tm1.2Jw

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Nxf2tm1.1Jw Nxf3tm1.1Jw/Y,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Nxf2tm1.2Jw/Y
Genetic Background: B6.Cg-Nxf2tm1.2Jw

Allelic Composition: Nxf2tm1.2Jw Nxf3tm1.2Jw/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Nxf2tm1.1Jw Nxf3tm1.1Jw/Y,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0004218 meiotic nondisjunction during M1 phase "abnormal separation of pairs of homologous chromosomes during anaphase of the first meiotic division such that each daughter cell receives one set of paired chromosomes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hsf4tm1Xyk/Hsf4tm1Xyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hsf4tm1Xyk/Hsf4tm1Xyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nxf2tm1.2Jw/Y
Genetic Background: B6.Cg-Nxf2tm1.2Jw

Allelic Composition: Nxf2tm1.2Jw Nxf3tm1.2Jw/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Nxf2tm1.1Jw Nxf3tm1.1Jw/Y,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nxf2tm1.2Jw/Y
Genetic Background: B6.Cg-Nxf2tm1.2Jw

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsf4tm1Xyk/Hsf4tm1Xyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nxf2tm1.2Jw/Y
Genetic Background: B6.Cg-Nxf2tm1.2Jw

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hsf4tm1Xyk/Hsf4tm1Xyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nxf2tm1.1Jw Nxf3tm1.1Jw/Y,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hsf4tm1Xyk/Hsf4tm1Xyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008995 early reproductive senescence "loss of reproductive capacity occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nxf2tm1.2Jw/Y
Genetic Background: B6.Cg-Nxf2tm1.2Jw

 MP:0009240 elongated sperm flagellum "increased length of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nxf2tm1.1Jw Nxf3tm1.1Jw/Y,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Rps7Zma/Rps7+,Tg(Dct-lacZ)IPav/0
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J * FVB/N

 MP:0011751 abnormal X-Y chromosome synapsis during male meiosis "an anomaly in the process in which the side by side pairing and physical juxtaposition of X and Y chromosomes is created at the metaphase plate, usually resulting in incorrect sex chromosome disjunction" [MGI:llw2]
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Allelic Composition: Nxf2tm1.1Jw Nxf3tm1.1Jw/Y,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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