ENSMUSG00000057000


Mus musculus

Features
Gene ID: ENSMUSG00000057000
  
Biological name :Nxf3
  
Synonyms : Nxf3
  
Possible biological names infered from orthology : nuclear RNA export factor 3 / Q9H4D5
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F1
Gene start: 136072099
Gene end: 136085255
  
Corresponding Affymetrix probe sets: 10606837 (MoGene1.0st)   1456035_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079730
Ensembl peptide - ENSMUSP00000121486
NCBI entrez gene - 245610     See in Manteia.
MGI - MGI:2685230
RefSeq - XM_017318498
RefSeq - NM_001024141
RefSeq - XM_006528534
RefSeq - XM_011247739
RefSeq - XM_011247740
RefSeq - XM_006528531
RefSeq - XM_006528532
RefSeq Peptide - NP_001019312
swissprot - Q4ZGD9
swissprot - B1AUS0
Ensembl - ENSMUSG00000057000
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nxf1ENSDARG00000055076Danio rerio
 zgc:153681ENSDARG00000086017Danio rerio
 NXF3ENSG00000147206Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nxf1 / Q99JX7 / Q9CQE2 / Nuclear RNA export factor 1 / Q9UBU9*ENSMUSG0000001009739
Nxf2 / NXF5* / NXF2B* / Q9GZY0* / Q9H1B4* / nuclear RNA export factor 2* / nuclear RNA export factor 5* / nuclear RNA export factor 2B*ENSMUSG0000000994137
Nxf7 / NXF2* / NXF5* / NXF2B* / Q9GZY0* / Q9H1B4* / nuclear RNA export factor 5* / nuclear RNA export factor 2* / nuclear RNA export factor 2B*ENSMUSG0000003141037


Protein motifs (from Interpro)
Interpro ID Name
 IPR002075  Nuclear transport factor 2
 IPR005637  TAP C-terminal (TAP-C) domain
 IPR009060  UBA-like superfamily
 IPR015245  Nuclear RNA export factor Tap, RNA-binding domain
 IPR018222  Nuclear transport factor 2, eukaryote
 IPR030216  Nuclear RNA export factor 3
 IPR030217  Nuclear RNA export factor
 IPR032710  NTF2-like domain superfamily
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006406 mRNA export from nucleus ISO
 biological_processGO:0016973 poly(A)+ mRNA export from nucleus IPI
 biological_processGO:0051028 mRNA transport IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0042272 nuclear RNA export factor complex ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Nxf2tm1.1Jw Nxf3tm1.1Jw/Y,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Nxf2tm1.1Jw Nxf3tm1.1Jw/Y,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Nxf2tm1.1Jw Nxf3tm1.1Jw/Y,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Nxf2tm1.1Jw Nxf3tm1.1Jw/Y,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Cryba2Aca30/Cryba2Aca30
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Nxf2tm1.1Jw Nxf3tm1.1Jw/Y,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nxf2tm1.2Jw Nxf3tm1.2Jw/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Nxf2tm1.1Jw Nxf3tm1.1Jw/Y,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Nxf2tm1.1Jw Nxf3tm1.1Jw/Y,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0009240 elongated sperm flagellum "increased length of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nxf2tm1.1Jw Nxf3tm1.1Jw/Y,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Rps7Zma/Rps7+,Tg(Dct-lacZ)IPav/0
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J * FVB/N

 MP:0011751 abnormal X-Y chromosome synapsis during male meiosis "an anomaly in the process in which the side by side pairing and physical juxtaposition of X and Y chromosomes is created at the metaphase plate, usually resulting in incorrect sex chromosome disjunction" [MGI:llw2]
Show

Allelic Composition: Nxf2tm1.1Jw Nxf3tm1.1Jw/Y,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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