ENSMUSG00000010476


Mus musculus

Features
Gene ID: ENSMUSG00000010476
  
Biological name :Ebf3
  
Synonyms : early B cell factor 3 / Ebf3 / O08791
  
Possible biological names infered from orthology : Q9H4W6
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 137193673
Gene end: 137314445
  
Corresponding Affymetrix probe sets: 10568735 (MoGene1.0st)   1428349_s_at (Mouse Genome 430 2.0 Array)   1452751_at (Mouse Genome 430 2.0 Array)   1460666_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033378
Ensembl peptide - ENSMUSP00000101724
Ensembl peptide - ENSMUSP00000130334
Ensembl peptide - ENSMUSP00000147512
Ensembl peptide - ENSMUSP00000147829
Ensembl peptide - ENSMUSP00000132563
NCBI entrez gene - 13593     See in Manteia.
MGI - MGI:894289
RefSeq - XM_011241672
RefSeq - NM_001113414
RefSeq - NM_001113415
RefSeq - NM_010096
RefSeq - XM_006507332
RefSeq - XM_006507333
RefSeq - XM_006507334
RefSeq - XM_006507335
RefSeq - XM_006507336
RefSeq - XM_006507337
RefSeq - XM_006507329
RefSeq - XM_006507330
RefSeq - XM_006507331
RefSeq Peptide - NP_001106886
RefSeq Peptide - NP_034226
RefSeq Peptide - NP_001106885
swissprot - O08791
swissprot - Q3UUB6
swissprot - Q6NXL3
Ensembl - ENSMUSG00000010476
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ebf3aENSDARG00000100244Danio rerio
 EBF3ENSGALG00000010461Gallus gallus
 EBF3ENSG00000108001Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ebf1 / Q07802 / early B cell factor 1 / Q9UH73*ENSMUSG0000005709888
Ebf2 / O08792 / early B cell factor 2 / Q9HAK2*ENSMUSG0000002205380
Ebf4 / Q8K4J2 / early B cell factor 4 / Q9BQW3*ENSMUSG0000005355273


Protein motifs (from Interpro)
Interpro ID Name
 IPR002909  IPT domain
 IPR003523  Transcription factor COE
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR018350  Transcription factor COE, conserved site
 IPR032200  Transcription factor COE, DNA-binding domain
 IPR032201  Transcription factor COE, helix-loop-helix domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

 MP:0012014 abnormal olfactory neuron innervation pattern "any changes in the placement, morphology or number of axons from olfactory neurons to an effector tissue or to olfactory glomeruli or olfactory bulb" [MGI:csmith]
Show

Allelic Composition: Ebf2tm1Reed/Ebf2+,Ebf3tm1Reed/Ebf3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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contact: otassy@igbmc.fr