MP:0000130 | abnormal cancellous bone morphology | "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ebf1tm1Rug/Ebf1tm1Rug Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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MP:0000333 | decreased bone marrow cell number | "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: Ebf1tm1Rug/Ebf1tm1Rug Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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MP:0000847 | abnormal metencephalon morphology | "any malformation or absence of the anterior part of the rhombencephalon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Tnftm2.1Gkl/Tnf+,Lyz2tm1(cre)Ifo/Lyz2+ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S6/SvEvTac * C57BL/6J
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Ebf1tm1Rug/Ebf1tm1Rug Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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MP:0001802 | arrested B cell development | "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607] |
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+ Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Cd79atm1(cre)Reth/Cd79a+ Genetic Background: involves: BALB/c * C57BL/6 * SJL
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MP:0001806 | decreased IgM | "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Ebf1tm1Rug/Ebf1tm1Rug Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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MP:0002397 | abnormal bone marrow morphology | "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ebf1tm1Rug/Ebf1tm1Rug Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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MP:0002628 | fatty liver | "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Ebf1tm1Rug/Ebf1tm1Rug Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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MP:0003055 | abnormal epiphyseal plate morphology | "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Ebf1tm1Rug/Ebf1tm1Rug Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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MP:0003795 | abnormal bone structure | |
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Allelic Composition: Ebf1tm1Rug/Ebf1tm1Rug Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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MP:0004077 | abnormal striatum morphology | "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Tnftm2.1Gkl/Tnf+,Lyz2tm1(cre)Ifo/Lyz2+ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S6/SvEvTac * C57BL/6J
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MP:0004103 | abnormal ventral striatum morphology | "any structural abnormality of the regions of the nucleus accumbens and some nuclei of the olfactory tubercule that lie ventral to the anterior commissure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Tnftm2.1Gkl/Tnf+,Lyz2tm1(cre)Ifo/Lyz2+ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S6/SvEvTac * C57BL/6J
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MP:0004277 | abnormal lateral ganglionic eminence morphology | "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the striatum; however, neocortex, thalamus, septum and olfactory bulb neurons are also partly derived from the LGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172] |
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Allelic Composition: Tnftm2.1Gkl/Tnf+,Lyz2tm1(cre)Ifo/Lyz2+ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S6/SvEvTac * C57BL/6J
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MP:0004939 | abnormal B cell morphology | "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0004978 | decreased B-1 B cell number | "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+,Tg(BCL2)#Wehi/0 Genetic Background: involves: C57BL/6 * C57BL/6JWehi * SJL * SJL/JWehi
Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Tg(Cr2-cre)3Cgn/0 Genetic Background: involves: C57BL/6 * SJL
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MP:0004984 | increased osteoclast cell number | "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ebf1tm1Rug/Ebf1tm1Rug Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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MP:0004988 | increased osteoblast cell number | "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ebf1tm1Rug/Ebf1tm1Rug Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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MP:0005014 | increased B cell number | "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+ Genetic Background: involves: C57BL/6 * SJL
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MP:0005017 | decreased B cell number | "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cep290tm1.1Jgg/Cep290tm1.1Jgg Genetic Background: involves: 129
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MP:0005093 | impaired B cell proliferation | "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+ Genetic Background: involves: C57BL/6 * SJL
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MP:0008128 | abnormal brain internal capsule morphology | "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tnftm2.1Gkl/Tnf+,Lyz2tm1(cre)Ifo/Lyz2+ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S6/SvEvTac * C57BL/6J
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MP:0008178 | decreased germinal center B cell number | "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149] |
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+ Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Ighg1tm1(cre)Cgn/Ighg1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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MP:0008182 | decreased marginal zone B cell number | "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149] |
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+ Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Cd19tm1(cre)Cgn/Cd19+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Tg(Cr2-cre)3Cgn/0 Genetic Background: involves: C57BL/6 * SJL
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MP:0008190 | decreased transitional stage B cell number | "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+ Genetic Background: involves: C57BL/6 * SJL
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MP:0008192 | abnormal germinal center B cell physiology | "abnormal function of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes" [CL:0000844, GO:0002314, ISBN:0781735149] |
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+ Genetic Background: involves: C57BL/6 * SJL
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MP:0008202 | absent B-1 B cells | "absence of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and are enriched for self-reactivity; B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas" [CL:0000819, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604] |
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0008208 | decreased pro-B cell number | "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0008209 | decreased pre-B cell number | "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+ Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+,Tg(BCL2)#Wehi/0 Genetic Background: involves: C57BL/6 * C57BL/6JWehi * SJL * SJL/JWehi
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MP:0008212 | absent mature B cells | "absence of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0008215 | decreased immature B cell number | "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+ Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+,Tg(BCL2)#Wehi/0 Genetic Background: involves: C57BL/6 * C57BL/6JWehi * SJL * SJL/JWehi
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MP:0008271 | abnormal bone ossification | "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503] |
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Allelic Composition: Ebf1tm1Rug/Ebf1tm1Rug Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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MP:0008482 | decreased spleen germinal center number | "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967] |
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+ Genetic Background: involves: C57BL/6 * SJL
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MP:0008495 | decreased IgG1 level | "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+ Genetic Background: involves: C57BL/6 * SJL
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MP:0008498 | decreased IgG3 level | "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+ Genetic Background: involves: C57BL/6 * SJL
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MP:0008782 | increased B cell apoptosis | "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Polr2atm1(cre/ERT2)Bbd/Polr2a+ Genetic Background: involves: C57BL/6 * SJL
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MP:0008844 | decreased subcutaneous adipose tissue amount | "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ebf1tm1Rug/Ebf1tm1Rug Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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MP:0009347 | increased cancellous bone thickness | "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ebf1tm1Rug/Ebf1tm1Rug Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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MP:0010860 | abnormal anterior commissure pars posterior morphology | "any structural anomaly of the large posterior part of the anterior commissure which connects the right and left temporal lobes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Tnftm2.1Gkl/Tnf+,Lyz2tm1(cre)Ifo/Lyz2+ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S6/SvEvTac * C57BL/6J
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MP:0012468 | decreased striatum area | "reduced size of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [ISBN:0838580343, MGI:csmith] |
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Allelic Composition: Tnftm2.1Gkl/Tnf+,Lyz2tm1(cre)Ifo/Lyz2+ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S6/SvEvTac * C57BL/6J
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MP:0020137 | decreased bone mineralization | "decrease in the rate at which minerals are deposited into bone" [] |
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Allelic Composition: Ebf1tm1Rug/Ebf1tm1Rug Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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MP:0020138 | delayed bone mineralization | "late onset of the process by which minerals are deposited into bone" [ORCID: orcid.org/0000-0003-4606-0597] |
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Allelic Composition: Ebf1tm1Rug/Ebf1tm1Rug Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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