ENSMUSG00000022053


Mus musculus

Features
Gene ID: ENSMUSG00000022053
  
Biological name :Ebf2
  
Synonyms : early B cell factor 2 / Ebf2 / O08792
  
Possible biological names infered from orthology : Q9HAK2
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D1
Gene start: 67233292
Gene end: 67430918
  
Corresponding Affymetrix probe sets: 10416126 (MoGene1.0st)   1418494_at (Mouse Genome 430 2.0 Array)   1449101_at (Mouse Genome 430 2.0 Array)   1449102_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022637
Ensembl peptide - ENSMUSP00000135500
Ensembl peptide - ENSMUSP00000135782
NCBI entrez gene - 13592     See in Manteia.
MGI - MGI:894332
RefSeq - XM_011244945
RefSeq - NM_001276387
RefSeq - NM_010095
RefSeq Peptide - NP_034225
RefSeq Peptide - NP_001263316
swissprot - O08792
Ensembl - ENSMUSG00000022053
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ebf2ENSDARG00000042525Danio rerio
 EBF2ENSGALG00000000242Gallus gallus
 EBF2ENSG00000221818Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ebf3 / O08791 / early B cell factor 3 / Q9H4W6*ENSMUSG0000001047683
Ebf1 / Q07802 / early B cell factor 1 / Q9UH73*ENSMUSG0000005709878
Ebf4 / Q8K4J2 / early B cell factor 4 / Q9BQW3*ENSMUSG0000005355270


Protein motifs (from Interpro)
Interpro ID Name
 IPR002909  IPT domain
 IPR003523  Transcription factor COE
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR018350  Transcription factor COE, conserved site
 IPR032200  Transcription factor COE, DNA-binding domain
 IPR032201  Transcription factor COE, helix-loop-helix domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001709 cell fate determination IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0035563 positive regulation of chromatin binding IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0050873 brown fat cell differentiation IDA
 biological_processGO:0060612 adipose tissue development IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Ebf2tm1.1Ggc/Ebf2tm1.1Ggc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
Show

Allelic Composition: Ebf2tm1.1Ggc/Ebf2tm1.1Ggc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ebf2tm2.1(Zfp423)Reed/Ebf2+
Genetic Background: Not Specified

 MP:0000837 abnormal hypothalamus morphology "any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Ebf2tm1.1Ggc/Ebf2tm1.1Ggc
Genetic Background: involves: 129S2/SvPas * C57BL/6J * FVB/N

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Ebf2tm1.1Ggc/Ebf2tm1.1Ggc
Genetic Background: involves: 129S2/SvPas * C57BL/6J * FVB/N

 MP:0000867 abnormal anterior vermis "malformation in the anterior portion of the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
Show

Allelic Composition: Ebf2tm1.1Ggc/Ebf2tm1.1Ggc
Genetic Background: involves: 129S2/SvPas * C57BL/6J * FVB/N

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Ebf2tm1.1Ggc/Ebf2tm1.1Ggc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
Show

Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Ebf2tm1.1Ggc/Ebf2tm1.1Ggc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Zfp423tm1Reed/Zfp423tm1Reed
Genetic Background: Not Specified

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Ebf2tm1.1Ggc/Ebf2tm1.1Ggc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001752 abnormal hypothalamus secretion "altered ability of the hypothalamus to release its contents" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0001940 testicular hypoplasia "decreased cell number in the testicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ebf2tm2(Zfp423)Reed/Ebf2+,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ebf2tm1.1Ggc/Ebf2tm1.1Ggc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Ebf2tm1.1Ggc/Ebf2tm1.1Ggc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ebf2tm1.1Ggc/Ebf2tm1.1Ggc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Ebf2tm1.1Ggc/Ebf2tm1.1Ggc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004853 abnormal ovary size "anomaly in the average size of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0004991 decreased bone strength "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ebf2tm1.1Ggc/Ebf2tm1.1Ggc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005236 abnormal olfactory nerve morphology "anomalous structure of the first cranial nerve, which conveys the sense of smell" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ebf2tm2.1(Zfp423)Reed/Ebf2+
Genetic Background: Not Specified

 MP:0005279 narcolepsy "recurring episodes of sleep during normal waking hours and often disrupted sleep during normal sleeping period; often accompanied by catplexy, sleep paralysis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83817]
Show

Allelic Composition: Kltm1Lex/Kltm1Lex
Genetic Background: B6.129S-Kltm1Lex

 MP:0006092 abnormal olfactory neuron morphology "malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]
Show

Allelic Composition: Ebf2tm2.1(Zfp423)Reed/Ebf2+
Genetic Background: Not Specified

Allelic Composition: Ebf2tm2.1(Zfp423)Reed/Ebf2+,Omptm1Mom/Omp+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ebf2tm2(Zfp423)Reed/Ebf2+,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ebf2tm1Reed/Ebf2+,Zfp423tm1Reed/Zfp423tm1Reed
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ebf2tm1Reed/Ebf2+,Olfr160tm4Mom/Olfr160+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Ebf2tm1Reed/Ebf2+,Olfr151tm26Mom/Olfr151+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Ebf2tm3.1(Zfp423*)Reed/Ebf2+,Olfr160tm4Mom/Olfr160+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

Allelic Composition: Ebf2tm3.1(Zfp423*)Reed/Ebf2+,Olfr17tm1Mom/Olfr17+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

Allelic Composition: Ebf2tm2.1(Zfp423)Reed/Ebf2+
Genetic Background: involves: 129 * C57BL/10J

Allelic Composition: Ebf2tm2(Zfp423)Reed/Ebf2+,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

 MP:0008152 decreased diameter of femur "reduced width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ebf2tm1.1Ggc/Ebf2tm1.1Ggc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
Show

Allelic Composition: Kltm1Lex/Kltm1Lex
Genetic Background: B6.129S-Kltm1Lex

 MP:0008789 abnormal olfactory epithelium morphology "any structural anomaly in the epithelial cells that line the interior of the nose" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ebf2tm2.1(Zfp423)Reed/Ebf2+
Genetic Background: Not Specified

Allelic Composition: Ebf2tm2.1(Zfp423)Reed/Ebf2+
Genetic Background: involves: 129 * C57BL/10J

Allelic Composition: Ebf2tm2(Zfp423)Reed/Ebf2+,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Kltm1Lex/Kltm1Lex
Genetic Background: B6.129S-Kltm1Lex

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
Show

Allelic Composition: Ebf2tm1.1Ggc/Ebf2tm1.1Ggc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

 MP:0011827 impaired neuron differentiation "decreased production of or inability to produce the mature cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith]
Show

Allelic Composition: Ebf2tm2.1(Zfp423)Reed/Ebf2+
Genetic Background: involves: 129 * C57BL/10J

Allelic Composition: Ebf2tm2(Zfp423)Reed/Ebf2+,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

 MP:0012014 abnormal olfactory neuron innervation pattern "any changes in the placement, morphology or number of axons from olfactory neurons to an effector tissue or to olfactory glomeruli or olfactory bulb" [MGI:csmith]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ebf2tm1Reed/Ebf2+,Ebf3tm1Reed/Ebf3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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