ENSMUSG00000011034


Mus musculus

Features
Gene ID: ENSMUSG00000011034
  
Biological name :Slc5a1
  
Synonyms : Slc5a1 / solute carrier family 5 (sodium/glucose cotransporter), member 1
  
Possible biological names infered from orthology : P13866 / solute carrier family 5 member 1
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B1
Gene start: 33104219
Gene end: 33162870
  
Corresponding Affymetrix probe sets: 10521038 (MoGene1.0st)   1419057_at (Mouse Genome 430 2.0 Array)   1455431_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000011178
NCBI entrez gene - 20537     See in Manteia.
MGI - MGI:107678
RefSeq - NM_019810
RefSeq Peptide - NP_062784
swissprot - Q9QXI6
Ensembl - ENSMUSG00000011034
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc5a1ENSDARG00000013871Danio rerio
 SLC5A1ENSGALG00000006728Gallus gallus
 P13866ENSG00000100170Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc5a4b / solute carrier family 5 (neutral amino acid transporters, system A), member 4b / Q9NY91* / SLC5A4* / solute carrier family 5 member 4*ENSMUSG0000002022671
Slc5a4a / Q9NY91* / SLC5A4* / solute carrier family 5 member 4*ENSMUSG0000002022969
Q923I7 / Slc5a2 / Sodium/glucose cotransporter 2 / P31639* / solute carrier family 5 member 2*ENSMUSG0000003078160
Q8VDT1 / Slc5a9 / Sodium/glucose cotransporter 4 / Q2M3M2* / solute carrier family 5 member 9*ENSMUSG0000002854456
Q8K0E3 / Slc5a11 / Sodium/myo-inositol cotransporter 2 / Q8WWX8* / solute carrier family 5 member 11*ENSMUSG0000003076951
Gm5134ENSMUSG0000003325549
Q5SWY8 / Slc5a10 / Sodium/glucose cotransporter 5 / A0PJK1* / solute carrier family 5 member 10*ENSMUSG0000004237148
Q9JKZ2 / Slc5a3 / Sodium/myo-inositol cotransporter / P53794* / solute carrier family 5 member 3*ENSMUSG0000008977446
Slc5a5 / solute carrier family 5 member 5 / Q92911*ENSMUSG0000000079220
Q8BYF6 / Slc5a8 / Sodium-coupled monocarboxylate transporter 1 / Q8N695* / solute carrier family 5 member 8*ENSMUSG0000002006220
Q49B93 / Slc5a12 / solute carrier family 5 (sodium/glucose cotransporter), member 12 / Q1EHB4* / solute carrier family 5 member 12*ENSMUSG0000004164419
Q5U4D8 / Slc5a6 / Sodium-dependent multivitamin transporter / Q9Y289* / solute carrier family 5 member 6*ENSMUSG0000000664118


Protein motifs (from Interpro)
Interpro ID Name
 IPR001734  Sodium/solute symporter
 IPR018212  Sodium/solute symporter, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1904659 glucose transmembrane transport IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031526 brush border membrane IEA
 molecular_functionGO:0005412 glucose:sodium symporter activity IEA
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Cellular hexose transport
Intestinal hexose absorption


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * CD-1 * FVB/N

 MP:0000489 abnormal large intestine morphology "structural or developmental anomalies of the intestinum crassum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * CD-1 * FVB/N

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001759 increased urine glucose level "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * CD-1 * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * CD-1 * FVB/N

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004348 long femur "increased length of the long bone of the thigh" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005619 increased potassium excretion "greater than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009480 distended cecum "an expansion in the volume of the large sac at the ileum and large intestine junction, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
Show

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

 MP:0011435 increased urine magnesium level "higher than normal amount of magnesium in the urine" [MGI:anna]
Show

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011447 abnormal renal glucose reabsorption "any anomaly in the process in which glucose is taken up from the collecting ducts and proximal and distal loops of the nephron" [GO:0035623]
Show

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

 MP:0011459 increased urine chloride ion level "abnormally large amounts of chloride ion in the urine" [MGI:csmith]
Show

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011466 increased urine urea nitrogen level "abnormally high amounts of nitrogen in the form of urea in the urine" [MGI:csmith]
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Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011923 abnormal urine volume "any anomaly in the amount of space occupied by urine in the bladder" [MPD:Molly]
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Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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