ENSMUSG00000006641


Mus musculus

Features
Gene ID: ENSMUSG00000006641
  
Biological name :Slc5a6
  
Synonyms : Q5U4D8 / Slc5a6 / Sodium-dependent multivitamin transporter
  
Possible biological names infered from orthology : Q9Y289 / solute carrier family 5 member 6
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B1
Gene start: 31036036
Gene end: 31048924
  
Corresponding Affymetrix probe sets: 10529052 (MoGene1.0st)   1435860_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110316
Ensembl peptide - ENSMUSP00000144349
Ensembl peptide - ENSMUSP00000079291
Ensembl peptide - ENSMUSP00000144665
Ensembl peptide - ENSMUSP00000143938
Ensembl peptide - ENSMUSP00000143993
NCBI entrez gene - 330064     See in Manteia.
MGI - MGI:2660847
RefSeq - NM_177870
RefSeq - XM_011240751
RefSeq - NM_001177621
RefSeq - NM_001177622
RefSeq Peptide - NP_001171092
RefSeq Peptide - NP_001171093
RefSeq Peptide - NP_808538
swissprot - A0A0J9YVH7
swissprot - F6WHY1
swissprot - Q5U4D8
Ensembl - ENSMUSG00000006641
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc5a6aENSDARG00000042859Danio rerio
 slc5a6bENSDARG00000014599Danio rerio
 SLC5A6ENSGALG00000040541Gallus gallus
 Q9Y289ENSG00000138074Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BYF6 / Slc5a8 / Sodium-coupled monocarboxylate transporter 1 / Q8N695* / solute carrier family 5 member 8*ENSMUSG0000002006241
Q49B93 / Slc5a12 / solute carrier family 5 (sodium/glucose cotransporter), member 12 / Q1EHB4* / solute carrier family 5 member 12*ENSMUSG0000004164438
Slc5a5 / solute carrier family 5 member 5 / Q92911*ENSMUSG0000000079236
Q923I7 / Slc5a2 / Sodium/glucose cotransporter 2 / P31639* / solute carrier family 5 member 2*ENSMUSG0000003078120
Q8VDT1 / Slc5a9 / Sodium/glucose cotransporter 4 / Q2M3M2* / solute carrier family 5 member 9*ENSMUSG0000002854420
Slc5a4b / solute carrier family 5 (neutral amino acid transporters, system A), member 4b / Q9NY91* / SLC5A4* / solute carrier family 5 member 4*ENSMUSG0000002022620
Slc5a4a / Q9NY91* / SLC5A4* / solute carrier family 5 member 4*ENSMUSG0000002022920
Q5SWY8 / Slc5a10 / Sodium/glucose cotransporter 5 / A0PJK1* / solute carrier family 5 member 10*ENSMUSG0000004237119
Slc5a1 / solute carrier family 5 (sodium/glucose cotransporter), member 1 / P13866* / solute carrier family 5 member 1*ENSMUSG0000001103419
Q8K0E3 / Slc5a11 / Sodium/myo-inositol cotransporter 2 / Q8WWX8* / solute carrier family 5 member 11*ENSMUSG0000003076919
Q9JKZ2 / Slc5a3 / Sodium/myo-inositol cotransporter / P53794* / solute carrier family 5 member 3*ENSMUSG0000008977418
Gm5134ENSMUSG0000003325515


Protein motifs (from Interpro)
Interpro ID Name
 IPR001734  Sodium/solute symporter
 IPR018212  Sodium/solute symporter, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0015878 biotin transport IEA
 biological_processGO:0015887 pantothenate transmembrane transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0012506 vesicle membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031526 brush border membrane IEA
 molecular_functionGO:0008523 sodium-dependent multivitamin transmembrane transporter activity IEA
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Biotin transport and metabolism
Vitamin B5 (pantothenate) metabolism
Transport of vitamins, nucleosides, and related molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0000489 abnormal large intestine morphology "structural or developmental anomalies of the intestinum crassum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0001671 abnormal vitamin absorption "anomalous ability to take in any of a group of organic substances, present in food, that are essential to normal metabolism" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0005400 abnormal vitamin level "anomalous concentration of any of the organic substances found in food that are necessary in trace amounts for normal metabolic function" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0008142 decreased small intestinal villus size "reduced size of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0009250 abnormal appendicular skeleton morphology "any structural anomaly of the bones of the limbs, shoulder and pelvic girdles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0009480 distended cecum "an expansion in the volume of the large sac at the ileum and large intestine junction, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0009485 distended ileum "an expansion in the volume of the portion of the small intestine that extends from the jejunum to the colon, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015668 Pdzd11 / Q9CZG9 / PDZ domain-containing protein 11 / Q5EBL8* / PDZ domain containing 11*  / complex






 

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