ENSMUSG00000089774


Mus musculus

Features
Gene ID: ENSMUSG00000089774
  
Biological name :Slc5a3
  
Synonyms : Q9JKZ2 / Slc5a3 / Sodium/myo-inositol cotransporter
  
Possible biological names infered from orthology : P53794 / solute carrier family 5 member 3
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: C4
Gene start: 92058322
Gene end: 92087473
  
Corresponding Affymetrix probe sets: 10436945 (MoGene1.0st)   1422170_at (Mouse Genome 430 2.0 Array)   1435484_at (Mouse Genome 430 2.0 Array)   1440227_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109608
Ensembl peptide - ENSMUSP00000139098
NCBI entrez gene - 53881     See in Manteia.
MGI - MGI:1858226
RefSeq - NM_017391
RefSeq Peptide - NP_059087
swissprot - Q9JKZ2
swissprot - V9GXD5
Ensembl - ENSMUSG00000089774
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc5a3aENSDARG00000010376Danio rerio
 slc5a3bENSDARG00000077812Danio rerio
 P53794ENSG00000198743Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8VDT1 / Slc5a9 / Sodium/glucose cotransporter 4 / Q2M3M2* / solute carrier family 5 member 9*ENSMUSG0000002854444
Q8K0E3 / Slc5a11 / Sodium/myo-inositol cotransporter 2 / Q8WWX8* / solute carrier family 5 member 11*ENSMUSG0000003076944
Q923I7 / Slc5a2 / Sodium/glucose cotransporter 2 / P31639* / solute carrier family 5 member 2*ENSMUSG0000003078142
Slc5a1 / solute carrier family 5 (sodium/glucose cotransporter), member 1 / P13866* / solute carrier family 5 member 1*ENSMUSG0000001103442
Slc5a4b / solute carrier family 5 (neutral amino acid transporters, system A), member 4b / Q9NY91* / SLC5A4* / solute carrier family 5 member 4*ENSMUSG0000002022641
Slc5a4a / Q9NY91* / SLC5A4* / solute carrier family 5 member 4*ENSMUSG0000002022940
Q5SWY8 / Slc5a10 / Sodium/glucose cotransporter 5 / A0PJK1* / solute carrier family 5 member 10*ENSMUSG0000004237138
Gm5134ENSMUSG0000003325534
Q49B93 / Slc5a12 / solute carrier family 5 (sodium/glucose cotransporter), member 12 / Q1EHB4* / solute carrier family 5 member 12*ENSMUSG0000004164417
Slc5a5 / solute carrier family 5 member 5 / Q92911*ENSMUSG0000000079217
Q8BYF6 / Slc5a8 / Sodium-coupled monocarboxylate transporter 1 / Q8N695* / solute carrier family 5 member 8*ENSMUSG0000002006217
Q5U4D8 / Slc5a6 / Sodium-dependent multivitamin transporter / Q9Y289* / solute carrier family 5 member 6*ENSMUSG0000000664116


Protein motifs (from Interpro)
Interpro ID Name
 IPR001734  Sodium/solute symporter
 IPR018212  Sodium/solute symporter, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006020 inositol metabolic process IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0007422 peripheral nervous system development IMP
 biological_processGO:0015798 myo-inositol transport IMP
 biological_processGO:0043576 regulation of respiratory gaseous exchange IMP
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0015293 symporter activity IBA
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Inositol transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001071 abnormal facial nerve morphology "malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
Show

Allelic Composition: Slc5a3tm1Skc/Slc5a3tm1Skc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001074 abnormal vagus nerve morphology "malformed or misprojection of autonomic, sensory and motor axons of the tenth cranial nerve to the pharynx, larynx, trachea, lungs, heart and GI tract" [Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
Show

Allelic Composition: Slc5a3tm1Skc/Slc5a3tm1Skc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001078 abnormal phrenic nerve "malformed or misprojection of motor and sensory neuron axons to the diaphragm and other tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Slc5a3tm1Skc/Slc5a3tm1Skc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001079 absent phrenic nerve "missing motor and sensory neuron axons to the diaphragm and other tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Slc5a3tm1Skc/Slc5a3tm1Skc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mc1re/Mc1re,Tg(KRT14-Kitl)1Takk/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Mc1re/Mc1re,Tg(KRT14-Kitl)1Takk/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Slc5a3tm1Skc/Slc5a3tm1Skc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Slc5a3tm1Gtb/Slc5a3+
Genetic Background: involves: 129X1/SvJ

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Mc1re/Mc1re,Tg(KRT14-Kitl)1Takk/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0001957 apnea "absence of breathing; sometimes episodic" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17384]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0002321 hypoventilation "reduced alveolar ventiliation relative to metabolic carbon dioxide production; results in alveolar carbon dioxide pressure increasing above normal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0003632 abnormal nervous system morphology 
Show

Allelic Composition: Slc5a3tm1Skc/Slc5a3tm1Skc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005403 abnormal nerve conduction "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc5a3tm1Skc/Slc5a3tm1Skc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Slc5a3tm1Skc/Slc5a3tm1Skc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0012172 abnormal amniotic fluid composition "any alteration in the expected chemical makeup of the watery liquid within the amnion that surrounds and cushions a growing fetus; normally, early in gestation, amniotic fluid is similar to maternal plasma, mainly water with electrolytes, and later in gestation, proteins, carbohydrates, lipids, phospholipids originating from the lungs, fetal cells, and urea are deposited in the fluid" [MGI:anna]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Slc5a3tm1Gtb/Slc5a3+
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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