ENSMUSG00000000792


Mus musculus

Features
Gene ID: ENSMUSG00000000792
  
Biological name :Slc5a5
  
Synonyms : Slc5a5 / solute carrier family 5 member 5
  
Possible biological names infered from orthology : Q92911
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: B3.3
Gene start: 70882889
Gene end: 70892757
  
Corresponding Affymetrix probe sets: 10579442 (MoGene1.0st)   1422113_at (Mouse Genome 430 2.0 Array)   1436239_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000809
NCBI entrez gene - 114479     See in Manteia.
MGI - MGI:2149330
RefSeq - NM_053248
RefSeq - XM_006509537
RefSeq Peptide - NP_444478
swissprot - G3X8P5
Ensembl - ENSMUSG00000000792
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc5a5ENSDARG00000005392Danio rerio
 SLC5A5ENSGALG00000041932Gallus gallus
 Q92911ENSG00000105641Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BYF6 / Slc5a8 / Sodium-coupled monocarboxylate transporter 1 / Q8N695* / solute carrier family 5 member 8*ENSMUSG0000002006247
Q49B93 / Slc5a12 / solute carrier family 5 (sodium/glucose cotransporter), member 12 / Q1EHB4* / solute carrier family 5 member 12*ENSMUSG0000004164442
Q5U4D8 / Slc5a6 / Sodium-dependent multivitamin transporter / Q9Y289* / solute carrier family 5 member 6*ENSMUSG0000000664137
Q8K0E3 / Slc5a11 / Sodium/myo-inositol cotransporter 2 / Q8WWX8* / solute carrier family 5 member 11*ENSMUSG0000003076924
Slc5a4b / solute carrier family 5 (neutral amino acid transporters, system A), member 4b / Q9NY91* / SLC5A4* / solute carrier family 5 member 4*ENSMUSG0000002022622
Q923I7 / Slc5a2 / Sodium/glucose cotransporter 2 / P31639* / solute carrier family 5 member 2*ENSMUSG0000003078122
Q5SWY8 / Slc5a10 / Sodium/glucose cotransporter 5 / A0PJK1* / solute carrier family 5 member 10*ENSMUSG0000004237122
Slc5a1 / solute carrier family 5 (sodium/glucose cotransporter), member 1 / P13866* / solute carrier family 5 member 1*ENSMUSG0000001103421
Q8VDT1 / Slc5a9 / Sodium/glucose cotransporter 4 / Q2M3M2* / solute carrier family 5 member 9*ENSMUSG0000002854421
Slc5a4a / Q9NY91* / SLC5A4* / solute carrier family 5 member 4*ENSMUSG0000002022921
Q9JKZ2 / Slc5a3 / Sodium/myo-inositol cotransporter / P53794* / solute carrier family 5 member 3*ENSMUSG0000008977420
Gm5134ENSMUSG0000003325519


Protein motifs (from Interpro)
Interpro ID Name
 IPR001734  Sodium/solute symporter
 IPR018212  Sodium/solute symporter, conserved site
 IPR035689  Sodium/iodide cotransporter


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006590 thyroid hormone generation IEA
 biological_processGO:0015705 iodide transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071371 cellular response to gonadotropin stimulus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008507 sodium:iodide symporter activity IEA
 molecular_functionGO:0015111 iodide transmembrane transporter activity IEA
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Thyroxine biosynthesis
Organic anion transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

 MP:0003186 abnormal redox activity "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

 MP:0005122 increased circulating thyroid-stimulating hormone level "greater than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

 MP:0005355 enlarged thyroid gland "increased size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:85158, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

 MP:0005479 decreased circulating triiodothyronine level "less than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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