ENSMUSG00000014852


Mus musculus

Features
Gene ID: ENSMUSG00000014852
  
Biological name :Adamts13
  
Synonyms : Adamts13 / A disintegrin and metalloproteinase with thrombospondin motifs 13 / Q769J6
  
Possible biological names infered from orthology : ADAM metallopeptidase with thrombospondin type 1 motif 13 / Q76LX8
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A3
Gene start: 26973416
Gene end: 27009628
  
Corresponding Affymetrix probe sets: 10470349 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000014996
Ensembl peptide - ENSMUSP00000099955
NCBI entrez gene - 279028     See in Manteia.
MGI - MGI:2685556
RefSeq - NM_001290465
RefSeq - XM_006498104
RefSeq - NM_001001322
RefSeq - NM_001290463
RefSeq - NM_001290464
RefSeq - XM_006498098
RefSeq - XM_006498100
RefSeq - XM_006498103
RefSeq Peptide - NP_001277394
RefSeq Peptide - NP_001001322
RefSeq Peptide - NP_001277392
RefSeq Peptide - NP_001277393
swissprot - Q769J6
swissprot - A2ALB3
Ensembl - ENSMUSG00000014852
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adamts13ENSDARG00000076270Danio rerio
 ADAMTS13ENSGALG00000033597Gallus gallus
 Q76LX8ENSG00000160323Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P59511 / Adamts20 / A disintegrin and metalloproteinase with thrombospondin motifs 20 / P59510* / ADAM metallopeptidase with thrombospondin type 1 motif 20*ENSMUSG0000002244924
Adamts9 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9 / Q9P2N4* / ADAM metallopeptidase with thrombospondin type 1 motif 9*ENSMUSG0000003002217
P59384 / Adamts15 / A disintegrin and metalloproteinase with thrombospondin motifs 15 / Q8TE58* / ADAM metallopeptidase with thrombospondin type 1 motif 15*ENSMUSG0000003345316
Q8BLI0 / Adamtsl1 / ADAMTS-like protein 1 / Q8N6G6* / ADAMTS like 1*ENSMUSG0000006611316
Adamtsl3 / ADAMTS-like 3 / P82987*ENSMUSG0000007046915
Papln / Q9EPX2 / Papilin / O95428* / papilin, proteoglycan like sulfated glycoprotein*ENSMUSG0000002122315
P97857 / Adamts1 / A disintegrin and metalloproteinase with thrombospondin motifs 1 / Q9UHI8* / ADAM metallopeptidase with thrombospondin type 1 motif 1*ENSMUSG0000002289315
Q8BNJ2 / Adamts4 / A disintegrin and metalloproteinase with thrombospondin motifs 4 / O75173* / ADAM metallopeptidase with thrombospondin type 1 motif 4*ENSMUSG0000000640314
Q80T21 / Adamtsl4 / ADAMTS-like protein 4 / Q6UY14* / ADAMTS like 4*ENSMUSG0000001585013
Q7TSK7 / Adamtsl2 / ADAMTS-like protein 2 / Q86TH1* / ADAMTS like 2*ENSMUSG0000003604013
Thsd4 / Q3UTY6 / Thrombospondin type-1 domain-containing protein 4 / Q6ZMP0* / thrombospondin type 1 domain containing 4*ENSMUSG0000003228913
Q9R001 / Adamts5 / A disintegrin and metalloproteinase with thrombospondin motifs 5 / Q9UNA0* / ADAM metallopeptidase with thrombospondin type 1 motif 5*ENSMUSG0000002289413
Adamts8 / A disintegrin and metalloproteinase with thrombospondin motifs 8 isoform 2 / Q9UP79* / ADAM metallopeptidase with thrombospondin type 1 motif 8*ENSMUSG0000003199413


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR006586  ADAM, cysteine-rich
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR035914  Spermadhesin, CUB domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0014075 response to amine IEA
 biological_processGO:0034341 response to interferon-gamma IEA
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0035864 response to potassium ion IEA
 biological_processGO:0043171 peptide catabolic process IEA
 biological_processGO:0070670 response to interleukin-4 IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0071353 cellular response to interleukin-4 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sftpdtm1Haw/Sftpdtm1Haw
Genetic Background: involves: C57BL/6J * CD-1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sftpdtm1Haw/Sftpdtm1Haw
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Adamts13tm2Dgi/Adamts13tm2Dgi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sftpdtm1Haw/Sftpdtm1Haw
Genetic Background: involves: C57BL/6J * CD-1

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sftpdtm1Haw/Sftpdtm1Haw
Genetic Background: involves: C57BL/6J * CD-1

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npy1rtm1Pern/Npy1rtm1Pern
Genetic Background: Not Specified

Allelic Composition: Adamts13tm1Dgi/Adamts13tm1Dgi
Genetic Background: B6.129X1-Adamts13tm1Dgi

Allelic Composition: Adamts13tm1Dgi/Adamts13tm1Dgi,Vwftm1Wgr/Vwftm1Wgr
Genetic Background: B6.129-Adamts13tm1Dgi Vwftm1Wgr

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Sftpdtm1Haw/Sftpdtm1Haw
Genetic Background: involves: C57BL/6J * CD-1

 MP:0004720 abnormal platelet morphology "any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Gria2tm1Rod/Gria2+
Genetic Background: B6.129-Gria2tm1Rod/J

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sftpdtm1Haw/Sftpdtm1Haw
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Adamts13tm1Myta/Adamts13tm1Myta
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Adamts13s/Adamts13s
Genetic Background: 129.B6-Adamts13s

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sftpdtm1Haw/Sftpdtm1Haw
Genetic Background: involves: C57BL/6J * CD-1

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sftpdtm1Haw/Sftpdtm1Haw
Genetic Background: involves: C57BL/6J * CD-1

 MP:0006298 abnormal platelet activation "anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adamts13tm1Myta/Adamts13tm1Myta
Genetic Background: involves: 129S6/SvEvTac

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gria2tm1Rod/Gria2+
Genetic Background: B6.129-Gria2tm1Rod/J

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gria2tm1Rod/Gria2+
Genetic Background: B6.129-Gria2tm1Rod/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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