ENSMUSG00000015850


Mus musculus

Features
Gene ID: ENSMUSG00000015850
  
Biological name :Adamtsl4
  
Synonyms : Adamtsl4 / ADAMTS-like protein 4 / Q80T21
  
Possible biological names infered from orthology : ADAMTS like 4 / Q6UY14
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.1
Gene start: 95676201
Gene end: 95687917
  
Corresponding Affymetrix probe sets: 10500183 (MoGene1.0st)   1451932_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015994
Ensembl peptide - ENSMUSP00000113424
Ensembl peptide - ENSMUSP00000120844
NCBI entrez gene - 229595     See in Manteia.
MGI - MGI:2389008
RefSeq - XM_017319545
RefSeq - NM_001301705
RefSeq - NM_144899
RefSeq - XM_006501369
RefSeq - XM_006501372
RefSeq Peptide - NP_001288634
RefSeq Peptide - NP_659148
swissprot - Q80T21
swissprot - D3Z0T6
Ensembl - ENSMUSG00000015850
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ADAMTSL4ENSDARG00000063407Danio rerio
 Q6UY14ENSG00000143382Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Thsd4 / Q3UTY6 / Thrombospondin type-1 domain-containing protein 4 / Q6ZMP0* / thrombospondin type 1 domain containing 4*ENSMUSG0000003228937
Papln / Q9EPX2 / Papilin / O95428* / papilin, proteoglycan like sulfated glycoprotein*ENSMUSG0000002122323
P59511 / Adamts20 / A disintegrin and metalloproteinase with thrombospondin motifs 20 / P59510* / ADAM metallopeptidase with thrombospondin type 1 motif 20*ENSMUSG0000002244922
Q7TSK7 / Adamtsl2 / ADAMTS-like protein 2 / Q86TH1* / ADAMTS like 2*ENSMUSG0000003604022
Adamts9 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9 / Q9P2N4* / ADAM metallopeptidase with thrombospondin type 1 motif 9*ENSMUSG0000003002221
Q8BLI0 / Adamtsl1 / ADAMTS-like protein 1 / Q8N6G6* / ADAMTS like 1*ENSMUSG0000006611320
Adamtsl3 / ADAMTS-like 3 / P82987*ENSMUSG0000007046919
Q769J6 / Adamts13 / A disintegrin and metalloproteinase with thrombospondin motifs 13 / Q76LX8* / ADAM metallopeptidase with thrombospondin type 1 motif 13*ENSMUSG0000001485217
P59384 / Adamts15 / A disintegrin and metalloproteinase with thrombospondin motifs 15 / Q8TE58* / ADAM metallopeptidase with thrombospondin type 1 motif 15*ENSMUSG0000003345314
Adamts8 / A disintegrin and metalloproteinase with thrombospondin motifs 8 isoform 2 / Q9UP79* / ADAM metallopeptidase with thrombospondin type 1 motif 8*ENSMUSG0000003199412
P97857 / Adamts1 / A disintegrin and metalloproteinase with thrombospondin motifs 1 / Q9UHI8* / ADAM metallopeptidase with thrombospondin type 1 motif 1*ENSMUSG0000002289312
Q9R001 / Adamts5 / A disintegrin and metalloproteinase with thrombospondin motifs 5 / Q9UNA0* / ADAM metallopeptidase with thrombospondin type 1 motif 5*ENSMUSG0000002289411
Q8BNJ2 / Adamts4 / A disintegrin and metalloproteinase with thrombospondin motifs 4 / O75173* / ADAM metallopeptidase with thrombospondin type 1 motif 4*ENSMUSG0000000640310


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR010294  ADAM-TS Spacer 1
 IPR010909  PLAC
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002064 epithelial cell development IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0030198 extracellular matrix organization IDA
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005614 interstitial matrix IDA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0002020 protease binding ISS
 molecular_functionGO:0008233 peptidase activity IEA


Pathways (from Reactome)
Pathway description
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrp5tvrm111B/Lrp5tvrm111B
Genetic Background: C57BL/6J-Lrp5tvrm111b/Pjn

 MP:0002864 abnormal ocular fundus morphology "malformation of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lrp5tvrm111B/Lrp5tvrm111B
Genetic Background: C57BL/6J-Lrp5tvrm111b/Pjn

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lrp5tvrm111B/Lrp5tvrm111B
Genetic Background: C57BL/6J-Lrp5tvrm111b/Pjn

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lrp5tvrm111B/Lrp5tvrm111B
Genetic Background: C57BL/6J-Lrp5tvrm111b/Pjn

 MP:0005263 ectopia lentis "congenital displacement of the lens due to defective zonule formation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lrp5tvrm111B/Lrp5tvrm111B
Genetic Background: C57BL/6J-Lrp5tvrm111b/Pjn

 MP:0012040 abnormal c wave shape "any anomaly in the graphical representation of the c wave in the electroretinogram; the ERG c-wave can be used to assess the functional integrity of the photoreceptors, the pigment epithelial cells and the interactions between them." [http:webvision.med.utah.edu/book/electrophysiology/the-electroretinogram-erg/, MGI:csmith]
Show

Allelic Composition: Lrp5tvrm111B/Lrp5tvrm111B
Genetic Background: C57BL/6J-Lrp5tvrm111b/Pjn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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