ENSMUSG00000030022


Mus musculus

Features
Gene ID: ENSMUSG00000030022
  
Biological name :Adamts9
  
Synonyms : Adamts9 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9
  
Possible biological names infered from orthology : ADAM metallopeptidase with thrombospondin type 1 motif 9 / Q9P2N4
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D1
Gene start: 92772699
Gene end: 92943492
  
Corresponding Affymetrix probe sets: 10546430 (MoGene1.0st)   10546432 (MoGene1.0st)   10546434 (MoGene1.0st)   10546450 (MoGene1.0st)   10546452 (MoGene1.0st)   10546454 (MoGene1.0st)   1430352_at (Mouse Genome 430 2.0 Array)   1431399_at (Mouse Genome 430 2.0 Array)   1437785_at (Mouse Genome 430 2.0 Array)   1446346_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126498
Ensembl peptide - ENSMUSP00000109065
NCBI entrez gene - 101401     See in Manteia.
MGI - MGI:1916320
RefSeq - XM_006505263
RefSeq - XM_006505260
RefSeq - XM_006505261
RefSeq - XM_006505262
RefSeq - NM_175314
RefSeq Peptide - NP_780523
swissprot - E9PYV8
swissprot - E9PUN6
Ensembl - ENSMUSG00000030022
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adamts9ENSDARG00000077778Danio rerio
 ADAMTS9ENSGALG00000041750Gallus gallus
 Q9P2N4ENSG00000163638Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P59511 / Adamts20 / A disintegrin and metalloproteinase with thrombospondin motifs 20 / P59510* / ADAM metallopeptidase with thrombospondin type 1 motif 20*ENSMUSG0000002244954
Q8BLI0 / Adamtsl1 / ADAMTS-like protein 1 / Q8N6G6* / ADAMTS like 1*ENSMUSG0000006611322
Adamtsl3 / ADAMTS-like 3 / P82987*ENSMUSG0000007046921
Papln / Q9EPX2 / Papilin / O95428* / papilin, proteoglycan like sulfated glycoprotein*ENSMUSG0000002122319
Thsd4 / Q3UTY6 / Thrombospondin type-1 domain-containing protein 4 / Q6ZMP0* / thrombospondin type 1 domain containing 4*ENSMUSG0000003228918
Q769J6 / Adamts13 / A disintegrin and metalloproteinase with thrombospondin motifs 13 / Q76LX8* / ADAM metallopeptidase with thrombospondin type 1 motif 13*ENSMUSG0000001485218
Q7TSK7 / Adamtsl2 / ADAMTS-like protein 2 / Q86TH1* / ADAMTS like 2*ENSMUSG0000003604017
Q80T21 / Adamtsl4 / ADAMTS-like protein 4 / Q6UY14* / ADAMTS like 4*ENSMUSG0000001585016
P59384 / Adamts15 / A disintegrin and metalloproteinase with thrombospondin motifs 15 / Q8TE58* / ADAM metallopeptidase with thrombospondin type 1 motif 15*ENSMUSG0000003345315
P97857 / Adamts1 / A disintegrin and metalloproteinase with thrombospondin motifs 1 / Q9UHI8* / ADAM metallopeptidase with thrombospondin type 1 motif 1*ENSMUSG0000002289313
Adamts8 / A disintegrin and metalloproteinase with thrombospondin motifs 8 isoform 2 / Q9UP79* / ADAM metallopeptidase with thrombospondin type 1 motif 8*ENSMUSG0000003199412
Q9R001 / Adamts5 / A disintegrin and metalloproteinase with thrombospondin motifs 5 / Q9UNA0* / ADAM metallopeptidase with thrombospondin type 1 motif 5*ENSMUSG0000002289411
Q8BNJ2 / Adamts4 / A disintegrin and metalloproteinase with thrombospondin motifs 4 / O75173* / ADAM metallopeptidase with thrombospondin type 1 motif 4*ENSMUSG0000000640311


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR002870  Peptidase M12B, propeptide
 IPR010294  ADAM-TS Spacer 1
 IPR012314  Peptidase M12B, GON-ADAMTSs
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003179 heart valve morphogenesis IMP
 biological_processGO:0003229 ventricular cardiac muscle tissue development IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0010596 negative regulation of endothelial cell migration IMP
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0035909 aorta morphogenesis IMP
 biological_processGO:0045636 positive regulation of melanocyte differentiation IGI
 biological_processGO:0048070 regulation of developmental pigmentation IGI
 biological_processGO:0090673 endothelial cell-matrix adhesion IMP
 biological_processGO:1903671 negative regulation of sprouting angiogenesis IMP
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004175 endopeptidase activity IDA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: A830005F24Riktm1.1(KOMP)Mbp/A830005F24Rik+
Genetic Background: C57BL/6N-A830005F24Riktm1.1(KOMP)Mbp/Ucd

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: A830005F24Riktm1.1(KOMP)Mbp/A830005F24Rik+
Genetic Background: C57BL/6N-A830005F24Riktm1.1(KOMP)Mbp/Ucd

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: Cdkn2atm2Brn/Cdkn2atm2Brn,Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)10BJvde/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0000394 absent melanin granules in hair follicle "missing pigment polymers in the hair follicles" [J:18378]
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Allelic Composition: Adamts9tm1.1Apte/Adamts9tm1.2Apte,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adamts5tm1Dgen/Adamts5tm1Dgen,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.129P2-Adamts9tm1Dgen Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5tm1Dgen,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts9tm1Dgen/Adamts9tm1Dgen,VcanTg(Hoxa1)1Chm/Vcan+
Genetic Background: B6.Cg-Adamts9tm1Dgen VcanTg(Hoxa1)1Chm

Allelic Composition: Adamts9tm1Dgen/Adamts9tm1Dgen,Fbln1Gt(XST011)Byg/Fbln1+
Genetic Background: B6.129P2-Adamts9tm1Dgen Fbln1Gt(XST011)Byg

Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5+,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1

Allelic Composition: Adamts9tm1.1Apte/Adamts9tm1.1Apte,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Adamts9tm1.1Apte/Adamts9tm1.2Apte,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts9tm1.2Apte/Adamts9+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Adamts5tm1Dgen/Adamts5tm1Dgen,Adamts9tm1.1Apte/Adamts9tm1.1Apte,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0000571 interdigital webbing "fold of skin, or web, between the toes that is not normally present" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts5tm1Dgen/Adamts5tm1Dgen
Genetic Background: B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5tm1Dgen,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts9tm1Dgen/Adamts9tm1Dgen,VcanTg(Hoxa1)1Chm/Vcan+
Genetic Background: B6.Cg-Adamts9tm1Dgen VcanTg(Hoxa1)1Chm

Allelic Composition: Adamts9tm1Dgen/Adamts9tm1Dgen,Fbln1Gt(XST011)Byg/Fbln1+
Genetic Background: B6.129P2-Adamts9tm1Dgen Fbln1Gt(XST011)Byg

Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5+,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1

Allelic Composition: Adamts9tm1.1Apte/Adamts9tm1.1Apte,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Adamts9tm1.1Apte/Adamts9tm1.2Apte,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
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Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: A830005F24Riktm1.1(KOMP)Mbp/A830005F24Rik+
Genetic Background: C57BL/6N-A830005F24Riktm1.1(KOMP)Mbp/Ucd

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5+,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2atm2Brn/Cdkn2atm2Brn,Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)10BJvde/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tshz1tm1Garr/Tshz1tm2.2Garr
Genetic Background: mixed

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: A830005F24Riktm1.1(KOMP)Mbp/A830005F24Rik+
Genetic Background: C57BL/6N-A830005F24Riktm1.1(KOMP)Mbp/Ucd

 MP:0002582 disorganized extraembryonic tissue "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
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Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

 MP:0005072 abnormal hair follicle melanin granule "anomalous pigment paricles in the hair follicles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts9tm1.2Apte/Adamts9+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0009783 abnormal melanoblast morphology "any structural anomaly of a cell that originates from the neural crest and differentiates into a pigment cell" [CL:0000541]
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Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5+,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts9tm1.2Apte/Adamts9+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts9tm1.2Apte/Adamts9+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5+,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5+,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts9tm1.2Apte/Adamts9tm1.2Apte
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Adamts9tm1.2Apte/Adamts9tm1.2Apte
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: A830005F24Riktm1.1(KOMP)Mbp/A830005F24Rik+
Genetic Background: C57BL/6N-A830005F24Riktm1.1(KOMP)Mbp/Ucd

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
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Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

 MP:0014134 abnormal embryo morphology "any structural anomaly of an embryo " [MGI:csmith]
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Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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