ENSG00000163638


Homo sapiens

Features
Gene ID: ENSG00000163638
  
Biological name :ADAMTS9
  
Synonyms : ADAM metallopeptidase with thrombospondin type 1 motif 9 / ADAMTS9 / Q9P2N4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p14.1
Gene start: 64515654
Gene end: 64688000
  
Corresponding Affymetrix probe sets: 1554697_at (Human Genome U133 Plus 2.0 Array)   220287_at (Human Genome U133 Plus 2.0 Array)   226814_at (Human Genome U133 Plus 2.0 Array)   233785_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000417521
Ensembl peptide - ENSP00000478086
Ensembl peptide - ENSP00000419217
Ensembl peptide - ENSP00000418735
Ensembl peptide - ENSP00000295903
NCBI entrez gene - 56999     See in Manteia.
OMIM - 605421
RefSeq - NM_182920
RefSeq - NM_001318781
RefSeq Peptide - NP_001305710
RefSeq Peptide - NP_891550
swissprot - Q9P2N4
swissprot - A0A087WTS1
swissprot - H0Y859
swissprot - C9JWI2
Ensembl - ENSG00000163638
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adamts9ENSDARG00000077778Danio rerio
 ADAMTS9ENSGALG00000041750Gallus gallus
 Adamts9ENSMUSG00000030022Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P59510 / ADAMTS20 / ADAM metallopeptidase with thrombospondin type 1 motif 20ENSG0000017315750
Q8TE58 / ADAMTS15 / ADAM metallopeptidase with thrombospondin type 1 motif 15ENSG0000016610621
Q9UHI8 / ADAMTS1 / ADAM metallopeptidase with thrombospondin type 1 motif 1ENSG0000015473419
Q9UP79 / ADAMTS8 / ADAM metallopeptidase with thrombospondin type 1 motif 8ENSG0000013491718
Q76LX8 / ADAMTS13 / ADAM metallopeptidase with thrombospondin type 1 motif 13ENSG0000016032318
O75173 / ADAMTS4 / ADAM metallopeptidase with thrombospondin type 1 motif 4ENSG0000015885917
Q9UNA0 / ADAMTS5 / ADAM metallopeptidase with thrombospondin type 1 motif 5ENSG0000015473617
P82987 / ADAMTSL3 / ADAMTS like 3ENSG0000015621816
Q8N6G6 / ADAMTSL1 / ADAMTS like 1ENSG0000017803116
Q86TH1 / ADAMTSL2 / ADAMTS like 2ENSG0000019785913
PAPLN / O95428 / papilin, proteoglycan like sulfated glycoproteinENSG0000010076713
THSD4 / Q6ZMP0 / thrombospondin type 1 domain containing 4ENSG0000018772013
Q6UY14 / ADAMTSL4 / ADAMTS like 4ENSG0000014338211


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR002870  Peptidase M12B, propeptide
 IPR010294  ADAM-TS Spacer 1
 IPR012314  Peptidase M12B, GON-ADAMTSs
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003179 heart valve morphogenesis ISS
 biological_processGO:0003229 ventricular cardiac muscle tissue development ISS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006516 glycoprotein catabolic process TAS
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0010596 negative regulation of endothelial cell migration ISS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0030198 extracellular matrix organization ISS
 biological_processGO:0035909 aorta morphogenesis ISS
 biological_processGO:0045636 positive regulation of melanocyte differentiation IEA
 biological_processGO:0048070 regulation of developmental pigmentation IEA
 biological_processGO:0090673 endothelial cell-matrix adhesion ISS
 biological_processGO:1903671 negative regulation of sprouting angiogenesis ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0031012 extracellular matrix ISS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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