ENSG00000158859


Homo sapiens

Features
Gene ID: ENSG00000158859
  
Biological name :ADAMTS4
  
Synonyms : ADAM metallopeptidase with thrombospondin type 1 motif 4 / ADAMTS4 / O75173
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q23.3
Gene start: 161184308
Gene end: 161199056
  
Corresponding Affymetrix probe sets: 1555380_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000356974
Ensembl peptide - ENSP00000356975
NCBI entrez gene - 9507     See in Manteia.
OMIM - 603876
RefSeq - NM_005099
RefSeq - NM_001320336
RefSeq Peptide - NP_001307265
RefSeq Peptide - NP_005090
swissprot - O75173
swissprot - Q5VTW1
Ensembl - ENSG00000158859
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000030502Gallus gallus
 Q8BNJ2ENSMUSG00000006403Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UHI8 / ADAMTS1 / ADAM metallopeptidase with thrombospondin type 1 motif 1ENSG0000015473449
Q8TE58 / ADAMTS15 / ADAM metallopeptidase with thrombospondin type 1 motif 15ENSG0000016610645
Q9UP79 / ADAMTS8 / ADAM metallopeptidase with thrombospondin type 1 motif 8ENSG0000013491743
Q9UNA0 / ADAMTS5 / ADAM metallopeptidase with thrombospondin type 1 motif 5ENSG0000015473639
Q9P2N4 / ADAMTS9 / ADAM metallopeptidase with thrombospondin type 1 motif 9ENSG0000016363838
P59510 / ADAMTS20 / ADAM metallopeptidase with thrombospondin type 1 motif 20ENSG0000017315737
Q76LX8 / ADAMTS13 / ADAM metallopeptidase with thrombospondin type 1 motif 13ENSG0000016032325
THSD4 / Q6ZMP0 / thrombospondin type 1 domain containing 4ENSG0000018772013
P82987 / ADAMTSL3 / ADAMTS like 3ENSG0000015621813
Q6UY14 / ADAMTSL4 / ADAMTS like 4ENSG0000014338213
Q8N6G6 / ADAMTSL1 / ADAMTS like 1ENSG0000017803113
Q86TH1 / ADAMTSL2 / ADAMTS like 2ENSG0000019785912
PAPLN / O95428 / papilin, proteoglycan like sulfated glycoproteinENSG0000010076712


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR010294  ADAM-TS Spacer 1
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development TAS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0022617 extracellular matrix disassembly TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0031012 extracellular matrix HDA
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0004222 metalloendopeptidase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity TAS
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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