ENSG00000154736


Homo sapiens

Features
Gene ID: ENSG00000154736
  
Biological name :ADAMTS5
  
Synonyms : ADAM metallopeptidase with thrombospondin type 1 motif 5 / ADAMTS5 / Q9UNA0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: -1
Band: q21.3
Gene start: 26917912
Gene end: 26966513
  
Corresponding Affymetrix probe sets: 1558636_s_at (Human Genome U133 Plus 2.0 Array)   219935_at (Human Genome U133 Plus 2.0 Array)   229357_at (Human Genome U133 Plus 2.0 Array)   235368_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000284987
NCBI entrez gene - 11096     See in Manteia.
OMIM - 605007
RefSeq - NM_007038
RefSeq - XM_011529448
RefSeq Peptide - NP_008969
swissprot - Q9UNA0
Ensembl - ENSG00000154736
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adamts5ENSDARG00000100307Danio rerio
 ADAMTS5ENSGALG00000015795Gallus gallus
 Q9R001ENSMUSG00000022894Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8TE58 / ADAMTS15 / ADAM metallopeptidase with thrombospondin type 1 motif 15ENSG0000016610640
Q9UHI8 / ADAMTS1 / ADAM metallopeptidase with thrombospondin type 1 motif 1ENSG0000015473440
Q9UP79 / ADAMTS8 / ADAM metallopeptidase with thrombospondin type 1 motif 8ENSG0000013491738
O75173 / ADAMTS4 / ADAM metallopeptidase with thrombospondin type 1 motif 4ENSG0000015885935
Q9P2N4 / ADAMTS9 / ADAM metallopeptidase with thrombospondin type 1 motif 9ENSG0000016363835
P59510 / ADAMTS20 / ADAM metallopeptidase with thrombospondin type 1 motif 20ENSG0000017315734
Q76LX8 / ADAMTS13 / ADAM metallopeptidase with thrombospondin type 1 motif 13ENSG0000016032320
Q86TH1 / ADAMTSL2 / ADAMTS like 2ENSG0000019785913
THSD4 / Q6ZMP0 / thrombospondin type 1 domain containing 4ENSG0000018772013
Q6UY14 / ADAMTSL4 / ADAMTS like 4ENSG0000014338213
P82987 / ADAMTSL3 / ADAMTS like 3ENSG0000015621813
Q8N6G6 / ADAMTSL1 / ADAMTS like 1ENSG0000017803112
PAPLN / O95428 / papilin, proteoglycan like sulfated glycoproteinENSG0000010076712


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR010294  ADAM-TS Spacer 1
 IPR013276  Peptidase M12B, ADAM-TS5
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis TAS
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0036066 protein O-linked fucosylation TAS
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0044691 tooth eruption IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 molecular_functionGO:0004222 metalloendopeptidase activity TAS
 molecular_functionGO:0005178 integrin binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity TAS
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050840 extracellular matrix binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr