ENSG00000154734


Homo sapiens

Features
Gene ID: ENSG00000154734
  
Biological name :ADAMTS1
  
Synonyms : ADAM metallopeptidase with thrombospondin type 1 motif 1 / ADAMTS1 / Q9UHI8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: -1
Band: q21.3
Gene start: 26835747
Gene end: 26845409
  
Corresponding Affymetrix probe sets: 222162_s_at (Human Genome U133 Plus 2.0 Array)   222486_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000403404
Ensembl peptide - ENSP00000431065
Ensembl peptide - ENSP00000429557
Ensembl peptide - ENSP00000284984
NCBI entrez gene - 9510     See in Manteia.
OMIM - 605174
RefSeq - NM_006988
RefSeq Peptide - NP_008919
swissprot - E5RJR7
swissprot - E5RI60
swissprot - H7C206
swissprot - Q9UHI8
Ensembl - ENSG00000154734
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adamts1ENSDARG00000103519Danio rerio
 ADAMTS1ENSGALG00000040342Gallus gallus
 P97857ENSMUSG00000022893Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8TE58 / ADAMTS15 / ADAM metallopeptidase with thrombospondin type 1 motif 15ENSG0000016610648
Q9UP79 / ADAMTS8 / ADAM metallopeptidase with thrombospondin type 1 motif 8ENSG0000013491745
O75173 / ADAMTS4 / ADAM metallopeptidase with thrombospondin type 1 motif 4ENSG0000015885943
Q9P2N4 / ADAMTS9 / ADAM metallopeptidase with thrombospondin type 1 motif 9ENSG0000016363839
Q9UNA0 / ADAMTS5 / ADAM metallopeptidase with thrombospondin type 1 motif 5ENSG0000015473638
P59510 / ADAMTS20 / ADAM metallopeptidase with thrombospondin type 1 motif 20ENSG0000017315738
Q76LX8 / ADAMTS13 / ADAM metallopeptidase with thrombospondin type 1 motif 13ENSG0000016032323
THSD4 / Q6ZMP0 / thrombospondin type 1 domain containing 4ENSG0000018772015
P82987 / ADAMTSL3 / ADAMTS like 3ENSG0000015621815
Q8N6G6 / ADAMTSL1 / ADAMTS like 1ENSG0000017803114
Q86TH1 / ADAMTSL2 / ADAMTS like 2ENSG0000019785914
PAPLN / O95428 / papilin, proteoglycan like sulfated glycoproteinENSG0000010076714
Q6UY14 / ADAMTSL4 / ADAMTS like 4ENSG0000014338213


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR010294  ADAM-TS Spacer 1
 IPR013274  Peptidase M12B, ADAM-TS1
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001542 ovulation from ovarian follicle IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007229 integrin-mediated signaling pathway TAS
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0060347 heart trabecula formation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity TAS
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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