ENSG00000166106


Homo sapiens

Features
Gene ID: ENSG00000166106
  
Biological name :ADAMTS15
  
Synonyms : ADAM metallopeptidase with thrombospondin type 1 motif 15 / ADAMTS15 / Q8TE58
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q24.3
Gene start: 130448974
Gene end: 130476641
  
Corresponding Affymetrix probe sets: 1553427_at (Human Genome U133 Plus 2.0 Array)   229004_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000299164
NCBI entrez gene - 170689     See in Manteia.
OMIM - 607509
RefSeq - NM_139055
RefSeq - XM_005271419
RefSeq Peptide - NP_620686
swissprot - Q8TE58
Ensembl - ENSG00000166106
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adamts15aENSDARG00000029124Danio rerio
 adamts15bENSDARG00000033544Danio rerio
 ADAMTS15ENSGALG00000001407Gallus gallus
 P59384ENSMUSG00000033453Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UHI8 / ADAMTS1 / ADAM metallopeptidase with thrombospondin type 1 motif 1ENSG0000015473449
Q9UP79 / ADAMTS8 / ADAM metallopeptidase with thrombospondin type 1 motif 8ENSG0000013491743
Q9P2N4 / ADAMTS9 / ADAM metallopeptidase with thrombospondin type 1 motif 9ENSG0000016363843
P59510 / ADAMTS20 / ADAM metallopeptidase with thrombospondin type 1 motif 20ENSG0000017315741
O75173 / ADAMTS4 / ADAM metallopeptidase with thrombospondin type 1 motif 4ENSG0000015885940
Q9UNA0 / ADAMTS5 / ADAM metallopeptidase with thrombospondin type 1 motif 5ENSG0000015473639
Q76LX8 / ADAMTS13 / ADAM metallopeptidase with thrombospondin type 1 motif 13ENSG0000016032324
Q6UY14 / ADAMTSL4 / ADAMTS like 4ENSG0000014338216
P82987 / ADAMTSL3 / ADAMTS like 3ENSG0000015621816
Q86TH1 / ADAMTSL2 / ADAMTS like 2ENSG0000019785916
THSD4 / Q6ZMP0 / thrombospondin type 1 domain containing 4ENSG0000018772015
Q8N6G6 / ADAMTSL1 / ADAMTS like 1ENSG0000017803115
PAPLN / O95428 / papilin, proteoglycan like sulfated glycoproteinENSG0000010076715


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR010294  ADAM-TS Spacer 1
 IPR013277  Peptidase M12B, ADAM-TS8
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009986 cell surface IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050840 extracellular matrix binding IEA


Pathways (from Reactome)
Pathway description
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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