ENSMUSG00000022894


Mus musculus

Features
Gene ID: ENSMUSG00000022894
  
Biological name :Adamts5
  
Synonyms : Adamts5 / A disintegrin and metalloproteinase with thrombospondin motifs 5 / Q9R001
  
Possible biological names infered from orthology : ADAM metallopeptidase with thrombospondin type 1 motif 5 / Q9UNA0
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C3.3
Gene start: 85858170
Gene end: 85901125
  
Corresponding Affymetrix probe sets: 10440534 (MoGene1.0st)   1422561_at (Mouse Genome 430 2.0 Array)   1450658_at (Mouse Genome 430 2.0 Array)   1456404_at (Mouse Genome 430 2.0 Array)   1456969_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023611
NCBI entrez gene - 23794     See in Manteia.
MGI - MGI:1346321
RefSeq - NM_011782
RefSeq Peptide - NP_035912
swissprot - Q9R001
Ensembl - ENSMUSG00000022894
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adamts5ENSDARG00000100307Danio rerio
 ADAMTS5ENSGALG00000015795Gallus gallus
 Q9UNA0ENSG00000154736Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P59384 / Adamts15 / A disintegrin and metalloproteinase with thrombospondin motifs 15 / Q8TE58* / ADAM metallopeptidase with thrombospondin type 1 motif 15*ENSMUSG0000003345341
P97857 / Adamts1 / A disintegrin and metalloproteinase with thrombospondin motifs 1 / Q9UHI8* / ADAM metallopeptidase with thrombospondin type 1 motif 1*ENSMUSG0000002289340
Adamts8 / A disintegrin and metalloproteinase with thrombospondin motifs 8 isoform 2 / Q9UP79* / ADAM metallopeptidase with thrombospondin type 1 motif 8*ENSMUSG0000003199438
P59511 / Adamts20 / A disintegrin and metalloproteinase with thrombospondin motifs 20 / P59510* / ADAM metallopeptidase with thrombospondin type 1 motif 20*ENSMUSG0000002244935
Q8BNJ2 / Adamts4 / A disintegrin and metalloproteinase with thrombospondin motifs 4 / O75173* / ADAM metallopeptidase with thrombospondin type 1 motif 4*ENSMUSG0000000640335
Q769J6 / Adamts13 / A disintegrin and metalloproteinase with thrombospondin motifs 13 / Q76LX8* / ADAM metallopeptidase with thrombospondin type 1 motif 13*ENSMUSG0000001485220
Adamts9 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9 / Q9P2N4* / ADAM metallopeptidase with thrombospondin type 1 motif 9*ENSMUSG0000003002216
Q7TSK7 / Adamtsl2 / ADAMTS-like protein 2 / Q86TH1* / ADAMTS like 2*ENSMUSG0000003604014
Q80T21 / Adamtsl4 / ADAMTS-like protein 4 / Q6UY14* / ADAMTS like 4*ENSMUSG0000001585013
Thsd4 / Q3UTY6 / Thrombospondin type-1 domain-containing protein 4 / Q6ZMP0* / thrombospondin type 1 domain containing 4*ENSMUSG0000003228913
Adamtsl3 / ADAMTS-like 3 / P82987*ENSMUSG0000007046913
Papln / Q9EPX2 / Papilin / O95428* / papilin, proteoglycan like sulfated glycoprotein*ENSMUSG0000002122313
Q8BLI0 / Adamtsl1 / ADAMTS-like protein 1 / Q8N6G6* / ADAMTS like 1*ENSMUSG0000006611312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR010294  ADAM-TS Spacer 1
 IPR013276  Peptidase M12B, ADAM-TS5
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0042742 defense response to bacterium IGI
 biological_processGO:0044691 tooth eruption IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008201 heparin binding IDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity ISO
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050840 extracellular matrix binding IDA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Enpp2tm1Mmas/Enpp2tm1Mmas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5tm1Dgen
Genetic Background: B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts5tm1Dgen/Adamts5+
Genetic Background: B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5+
Genetic Background: B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts5tm1Dgen/Adamts5tm1Dgen
Genetic Background: B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts5tm1Dgen/Adamts5tm1Dgen,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.129P2-Adamts9tm1Dgen Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5tm1Dgen,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5+,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts5tm1Dgen/Adamts5tm1Dgen,Adamts9tm1.1Apte/Adamts9tm1.1Apte,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0000571 interdigital webbing "fold of skin, or web, between the toes that is not normally present" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Enpp2tm1Mmas/Enpp2tm1Mmas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5tm1Dgen
Genetic Background: B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts5tm1Dgen/Adamts5+
Genetic Background: B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5+
Genetic Background: B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts5tm1Dgen/Adamts5tm1Dgen
Genetic Background: B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts5tm1Dgen/Adamts5tm1Dgen,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.129P2-Adamts9tm1Dgen Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5tm1Dgen,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5+,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
Show

Allelic Composition: Oas1bFlv-r/Oas1bFlv-r
Genetic Background: C3.PRI-Oas1bFlv-r

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spry2tm1Mrt/Spry2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
Show

Allelic Composition: Rai1tm1Jrl/Rai1+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

Allelic Composition: Adamts5tm1.1Eam/Adamts5+
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Adamts5tm2.2Lex/Adamts5tm2.2Lex
Genetic Background: B6.129S5-Adamts5tm2.2Lex

 MP:0003560 osteoarthritis "a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95374]
Show

Allelic Composition: Adamts4tm1Lex/Adamts4tm1Lex,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ

 MP:0009874 abnormal interdigital cell death "change in the expected number of cells undergoing programmed cell death (apoptosis) in the autopod during development, precluding the sculpting of normal digits" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts5tm1Dgen/Adamts5tm1Dgen
Genetic Background: B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr