ENSMUSG00000022449


Mus musculus

Features
Gene ID: ENSMUSG00000022449
  
Biological name :Adamts20
  
Synonyms : Adamts20 / A disintegrin and metalloproteinase with thrombospondin motifs 20 / P59511
  
Possible biological names infered from orthology : ADAM metallopeptidase with thrombospondin type 1 motif 20 / P59510
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E3
Gene start: 94270163
Gene end: 94465418
  
Corresponding Affymetrix probe sets: 10431749 (MoGene1.0st)   1456901_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036330
Ensembl peptide - ENSMUSP00000121696
NCBI entrez gene - 223838     See in Manteia.
MGI - MGI:2660628
RefSeq - XM_017316581
RefSeq - NM_001164785
RefSeq - NM_177431
RefSeq - XM_006520863
RefSeq - XM_011245594
RefSeq Peptide - NP_001158257
RefSeq Peptide - NP_803180
swissprot - P59511
Ensembl - ENSMUSG00000022449
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ADAMTS20ENSGALG00000009572Gallus gallus
 P59510ENSG00000173157Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adamts9 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9 / Q9P2N4* / ADAM metallopeptidase with thrombospondin type 1 motif 9*ENSMUSG0000003002238
P59384 / Adamts15 / A disintegrin and metalloproteinase with thrombospondin motifs 15 / Q8TE58* / ADAM metallopeptidase with thrombospondin type 1 motif 15*ENSMUSG0000003345321
P97857 / Adamts1 / A disintegrin and metalloproteinase with thrombospondin motifs 1 / Q9UHI8* / ADAM metallopeptidase with thrombospondin type 1 motif 1*ENSMUSG0000002289320
Adamts8 / A disintegrin and metalloproteinase with thrombospondin motifs 8 isoform 2 / Q9UP79* / ADAM metallopeptidase with thrombospondin type 1 motif 8*ENSMUSG0000003199419
Q769J6 / Adamts13 / A disintegrin and metalloproteinase with thrombospondin motifs 13 / Q76LX8* / ADAM metallopeptidase with thrombospondin type 1 motif 13*ENSMUSG0000001485218
Q9R001 / Adamts5 / A disintegrin and metalloproteinase with thrombospondin motifs 5 / Q9UNA0* / ADAM metallopeptidase with thrombospondin type 1 motif 5*ENSMUSG0000002289417
Adamtsl3 / ADAMTS-like 3 / P82987*ENSMUSG0000007046917
Q8BNJ2 / Adamts4 / A disintegrin and metalloproteinase with thrombospondin motifs 4 / O75173* / ADAM metallopeptidase with thrombospondin type 1 motif 4*ENSMUSG0000000640317
Q8BLI0 / Adamtsl1 / ADAMTS-like protein 1 / Q8N6G6* / ADAMTS like 1*ENSMUSG0000006611316
Papln / Q9EPX2 / Papilin / O95428* / papilin, proteoglycan like sulfated glycoprotein*ENSMUSG0000002122313
Thsd4 / Q3UTY6 / Thrombospondin type-1 domain-containing protein 4 / Q6ZMP0* / thrombospondin type 1 domain containing 4*ENSMUSG0000003228913
Q7TSK7 / Adamtsl2 / ADAMTS-like protein 2 / Q86TH1* / ADAMTS like 2*ENSMUSG0000003604013
Q80T21 / Adamtsl4 / ADAMTS-like protein 4 / Q6UY14* / ADAMTS like 4*ENSMUSG0000001585012


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR002870  Peptidase M12B, propeptide
 IPR010294  ADAM-TS Spacer 1
 IPR012314  Peptidase M12B, GON-ADAMTSs
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IDA
 biological_processGO:0009967 positive regulation of signal transduction IMP
 biological_processGO:0030198 extracellular matrix organization IDA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045636 positive regulation of melanocyte differentiation IMP
 biological_processGO:0048070 regulation of developmental pigmentation IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0004175 endopeptidase activity IDA
 molecular_functionGO:0004222 metalloendopeptidase activity IDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr3m1Btlr/Npr3m1Btlr
Genetic Background: C57BL/6J-Npr3m1Btlr

 MP:0000394 absent melanin granules in hair follicle "missing pigment polymers in the hair follicles" [J:18378]
Show

Allelic Composition: Adamts9tm1.1Apte/Adamts9tm1.2Apte,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5tm1Dgen
Genetic Background: B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts5tm1Dgen/Adamts5+
Genetic Background: B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5+
Genetic Background: B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1
Genetic Background: B6.Cg-Adamts20bt-Bei1

Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts5tm1Dgen/Adamts5tm1Dgen
Genetic Background: B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5tm1Dgen,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5+,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1

Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts9tm1.2Apte/Adamts9+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0000571 interdigital webbing "fold of skin, or web, between the toes that is not normally present" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Enpp2tm1Mmas/Enpp2tm1Mmas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts5tm1Dgen/Adamts5+
Genetic Background: B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5+
Genetic Background: B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1
Genetic Background: B6.Cg-Adamts20bt-Bei1

Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts5tm1Dgen/Adamts5tm1Dgen
Genetic Background: B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5tm1Dgen,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5+,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5+,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-4J/Adamts20bt-4J
Genetic Background: C3H/HeSnJ

Allelic Composition: Adamts20bt-5J/Adamts20bt-5J
Genetic Background: DBA/2J

Allelic Composition: Adamts20bt/Adamts20bt-6J
Genetic Background: Not Specified

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb-1R/Leprdb-1R
Genetic Background: involves: D7R75M

Allelic Composition: Adamts20bt-1R/Adamts20bt-1R
Genetic Background: C3H/Rl-Adamts20bt-1R/R

 MP:0002671 belted "the appearance of a stripe of white fur around the circumference of the abdomen" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb-1R/Leprdb-1R
Genetic Background: involves: D7R75M

Allelic Composition: Adamts20bt-1R/Adamts20bt-1R
Genetic Background: C3H/Rl-Adamts20bt-1R/R

Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1
Genetic Background: involves: C57BL/6

Allelic Composition: Adamts20bt-Mri1/Adamts20bt-Mri1
Genetic Background: involves: C57BL/6

Allelic Composition: Adamts20bt-8J/Adamts20bt-8J
Genetic Background: C57BL/6J-Adamts20bt-8J

Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

Allelic Composition: Adamts20bt-J/Adamts20bt-J
Genetic Background: CBA/J-Adamts20bt-J

Allelic Composition: Adamts20bt/Adamts20bt,Mc1re/Mc1re
Genetic Background: involves: C57BL/6Ha * DBA

Allelic Composition: Adamts20sp2/Adamts20sp2
Genetic Background: C57BL/6J-Adamts20sp2

Allelic Composition: Adamts20bt-2H/Adamts20bt-2H
Genetic Background: JU.Cg-Adamts20bt-2H

Allelic Composition: Adamts20bt-2H/Adamts20bt-2H
Genetic Background: B6.Cg-Adamts20bt-2H

Allelic Composition: Adamts20bt-2H/Adamts20bt-2H,Tg(Dct-LacZ)A12Jkn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Adamts20bt-2H/Adamts20bt-2H,Kittm1Alf/Kittm1Alf
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Adamts20bt-2H/Adamts20bt-2H,Kittm1Alf/Kit+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Adamts20m2Btlr/Adamts20m2Btlr
Genetic Background: C57BL/6J-Adamts20m2Btlr

Allelic Composition: Adamts20hip/Adamts20hip
Genetic Background: either: C57BL/6Apb-Adamts20hip or (involves: C57BL/6Apb * CBA)

Allelic Composition: Adamts20bt-4J/Adamts20bt-4J
Genetic Background: C3H/HeSnJ

Allelic Composition: Adamts20bt-5J/Adamts20bt-5J
Genetic Background: DBA/2J

Allelic Composition: Adamts20bt/Adamts20bt-6J
Genetic Background: Not Specified

Allelic Composition: Adamts20m3Btlr/Adamts20m3Btlr
Genetic Background: C57BL/6J-Adamts20m3Btlr

Allelic Composition: Adamts20bt-10J/Adamts20bt-10J
Genetic Background: C57BL/6J-Adamts20bt-10J/GrsrJ

Allelic Composition: Adamts20m4Btlr/Adamts20m4Btlr
Genetic Background: C57BL/6J-Adamts20m4Btlr

Allelic Composition: Adamts20m5Btlr/Adamts20m5Btlr
Genetic Background: C57BL/6J-Adamts20m5Btlr

Allelic Composition: Adamts20m6Btlr/Adamts20m6Btlr
Genetic Background: C57BL/6J-Adamts20m6Btlr

Allelic Composition: Adamts20m7Btlr/Adamts20m7Btlr
Genetic Background: C57BL/6J-Adamts20m7Btlr

 MP:0002938 white spotting "the appearance of patches of white fur" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adamts20bt-2H/Adamts20bt-2H
Genetic Background: JU.Cg-Adamts20bt-2H

Allelic Composition: Adamts20bt-2H/Adamts20bt-2H
Genetic Background: B6.Cg-Adamts20bt-2H

Allelic Composition: Adamts20bt-2H/Adamts20bt-2H,Tg(Dct-LacZ)A12Jkn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Adamts20bt-2H/Adamts20bt-2H,Kittm1Alf/Kittm1Alf
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Adamts20bt-2H/Adamts20bt-2H,Kittm1Alf/Kit+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Adamts20hip/Adamts20hip
Genetic Background: either: C57BL/6Apb-Adamts20hip or (involves: C57BL/6Apb * CBA)

Allelic Composition: Adamts20bt-4J/Adamts20bt-4J
Genetic Background: C3H/HeSnJ

Allelic Composition: Adamts20bt-5J/Adamts20bt-5J
Genetic Background: DBA/2J

 MP:0003136 yellow coat color "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is increased compared to wild-type agouti" [llw2:Linda L. Washburn, Mouse Genome Informatics Curator]
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Allelic Composition: Adamts20bt/Adamts20bt,Mc1re/Mc1re
Genetic Background: involves: C57BL/6Ha * DBA

 MP:0004381 abnormal hair follicle melanocyte morphology "any structural anomaly of the cells that produce pigment in the hair follicles" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Adamts20bt-J/Adamts20bt-J
Genetic Background: CBA/J-Adamts20bt-J

 MP:0005072 abnormal hair follicle melanin granule "anomalous pigment paricles in the hair follicles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts9tm1.2Apte/Adamts9+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0009555 abnormal hair follicle melanin granule distribution "anomaly in the spatial arrangement of particles produced by melanocytes that confer color in the hair follicle" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

 MP:0009783 abnormal melanoblast morphology "any structural anomaly of a cell that originates from the neural crest and differentiates into a pigment cell" [CL:0000541]
Show

Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5+,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen

Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts9tm1.2Apte/Adamts9+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0009784 abnormal melanoblast migration "defect in the dispersion of the cells that originate from the neural crest and differentiate into pigment cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adamts20bt-J/Adamts20bt-J
Genetic Background: CBA/J-Adamts20bt-J

Allelic Composition: Adamts20bt-2H/Adamts20bt-2H,Tg(Dct-LacZ)A12Jkn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0009874 abnormal interdigital cell death "change in the expected number of cells undergoing programmed cell death (apoptosis) in the autopod during development, precluding the sculpting of normal digits" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts5tm1Dgen/Adamts5tm1Dgen
Genetic Background: B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts9tm1.2Apte/Adamts9+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Adamts20bt-Bei1/Adamts20+,Adamts5tm1Dgen/Adamts5+,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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