ENSMUSG00000017288


Mus musculus

Features
Gene ID: ENSMUSG00000017288
  
Biological name :Vps53
  
Synonyms : Q8CCB4 / Vps53 / VPS53 GARP complex subunit
  
Possible biological names infered from orthology : Q5VIR6
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B5
Gene start: 76046226
Gene end: 76179647
  
Corresponding Affymetrix probe sets: 10388492 (MoGene1.0st)   1416989_at (Mouse Genome 430 2.0 Array)   1436327_a_at (Mouse Genome 430 2.0 Array)   1455644_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104057
Ensembl peptide - ENSMUSP00000131663
Ensembl peptide - ENSMUSP00000131387
Ensembl peptide - ENSMUSP00000130499
Ensembl peptide - ENSMUSP00000129159
Ensembl peptide - ENSMUSP00000128856
Ensembl peptide - ENSMUSP00000127364
Ensembl peptide - ENSMUSP00000126125
Ensembl peptide - ENSMUSP00000061317
Ensembl peptide - ENSMUSP00000091554
NCBI entrez gene - 68299     See in Manteia.
MGI - MGI:1915549
RefSeq - NM_026664
RefSeq - XM_006534052
RefSeq - XM_006534053
RefSeq Peptide - NP_080940
swissprot - E9PXG9
swissprot - E9PWD1
swissprot - E9Q8C4
swissprot - Q8CCB4
swissprot - F6Z4G7
swissprot - E9Q648
swissprot - E9Q3C3
swissprot - E9Q124
swissprot - E9PYD3
Ensembl - ENSMUSG00000017288
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vps53ENSDARG00000069324Danio rerio
 VPS53ENSGALG00000042071Gallus gallus
 VPS53ENSG00000141252Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007234  Vps53-like, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007041 lysosomal transport ISO
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0032456 endocytic recycling ISO
 biological_processGO:0042147 retrograde transport, endosome to Golgi ISS
 cellular_componentGO:0000938 GARP complex ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005802 trans-Golgi network ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 cellular_componentGO:0055037 recycling endosome ISS
 cellular_componentGO:1990745 EARP complex ISO


Pathways (from Reactome)
Pathway description
Retrograde transport at the Trans-Golgi-Network


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Cd3gtm1.1Cage/Cd3gtm1.1Cage,Tg(TcrLCMV)318Sdz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Cd3gtm1.1Cage/Cd3gtm1.1Cage,Tg(TcrLCMV)318Sdz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd3gtm1.1Cage/Cd3gtm1.1Cage,Tg(TcrLCMV)318Sdz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

 MP:0009397 increased trophoblast giant cell number "greater than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd3gtm1.1Cage/Cd3gtm1.1Cage,Tg(TcrLCMV)318Sdz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Cd3gtm1.1Cage/Cd3gtm1.1Cage,Tg(TcrLCMV)318Sdz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020128 Vps54 / Q5SPW0 / VPS54 GARP complex subunit / Q9P1Q0*  / complex
 ENSMUSG00000024799 Q3UVL4 / Q71KT5 / Tm7sf2 / transmembrane 7 superfamily member 2 / VPS51* / Q9UID3* / VPS51, GARP complex subunit*  / complex
 ENSMUSG00000024319 Vps52 / Q8C754 / VPS52 GARP complex subunit / Q8N1B4*  / complex






 

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