ENSMUSG00000024799


Mus musculus

Features
Gene ID: ENSMUSG00000024799
  
Biological name :Tm7sf2
  
Synonyms : Q3UVL4 / Q71KT5 / Tm7sf2 / transmembrane 7 superfamily member 2
  
Possible biological names infered from orthology : Q9UID3 / VPS51 / VPS51, GARP complex subunit
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 6062821
Gene end: 6077197
  
Corresponding Affymetrix probe sets: 10465342 (MoGene1.0st)   10465354 (MoGene1.0st)   1429834_a_at (Mouse Genome 430 2.0 Array)   1438205_at (Mouse Genome 430 2.0 Array)   1454825_at (Mouse Genome 430 2.0 Array)   1460684_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025713
Ensembl peptide - ENSMUSP00000109171
Ensembl peptide - ENSMUSP00000125586
Ensembl peptide - ENSMUSP00000125543
Ensembl peptide - ENSMUSP00000124868
Ensembl peptide - ENSMUSP00000124847
Ensembl peptide - ENSMUSP00000124825
Ensembl peptide - ENSMUSP00000124283
Ensembl peptide - ENSMUSP00000123989
Ensembl peptide - ENSMUSP00000025711
NCBI entrez gene - 68505     See in Manteia.
NCBI entrez gene - 73166     See in Manteia.
MGI - MGI:1920416
RefSeq - NM_001081041
RefSeq - NM_028454
RefSeq Peptide - NP_001074510
RefSeq Peptide - NP_082730
swissprot - E0CX82
swissprot - E0CX74
swissprot - Q3UVL4
swissprot - Q3V3I6
swissprot - E9Q4M8
swissprot - Q71KT5
swissprot - E0CZB2
swissprot - E0CZ93
swissprot - E0CYD6
swissprot - E0CX92
Ensembl - ENSMUSG00000024799
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vps51ENSDARG00000062016Danio rerio
 VPS51ENSGALG00000004166Gallus gallus
 VPS51ENSG00000149823Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vps51 / Q3UVL4 / VPS51 GARP complex subunit / Q9UID3*ENSMUSG00000024797100


Protein motifs (from Interpro)
Interpro ID Name
 IPR001171  Ergosterol biosynthesis ERG4/ERG24
 IPR014812  Vacuolar protein sorting-associated protein 51
 IPR016159  Cullin repeat-like-containing domain superfamily
 IPR018083  Sterol reductase, conserved site
 IPR035899  Dbl homology (DH) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006695 cholesterol biosynthetic process IEA
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0006914 autophagy ISO
 biological_processGO:0007030 Golgi organization IBA
 biological_processGO:0007041 lysosomal transport ISO
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016126 sterol biosynthetic process IBA
 biological_processGO:0032456 endocytic recycling IBA
 biological_processGO:0042147 retrograde transport, endosome to Golgi ISS
 biological_processGO:0048193 Golgi vesicle transport IBA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0000938 GARP complex ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005802 trans-Golgi network ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IBA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0043235 receptor complex ISO
 cellular_componentGO:0055037 recycling endosome ISS
 cellular_componentGO:1990745 EARP complex ISO
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IBA
 molecular_functionGO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0050613 delta14-sterol reductase activity IEA
 molecular_functionGO:0050661 NADP binding ISS


Pathways (from Reactome)
Pathway description
Retrograde transport at the Trans-Golgi-Network


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Lbric-J/Lbr+,Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lbric-J/Lbr+,Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lbric-J/Lbr+,Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Lbric-J/Lbr+,Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lbric-J/Lbr+,Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Lbric-J/Lbr+,Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lbric-J/Lbr+,Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lbric-J/Lbr+,Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
Show

Allelic Composition: Lbric-J/Lbr+,Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008730 fused phalanges "anomaly of the long bones of the digits resulting in some or all the bones being joined together" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Lbric-J/Lbr+,Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020128 Vps54 / Q5SPW0 / VPS54 GARP complex subunit / Q9P1Q0*  / complex
 ENSMUSG00000017288 Vps53 / Q8CCB4 / VPS53 GARP complex subunit / Q5VIR6*  / complex
 ENSMUSG00000024319 Vps52 / Q8C754 / VPS52 GARP complex subunit / Q8N1B4*  / complex






 

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