ENSMUSG00000024319


Mus musculus

Features
Gene ID: ENSMUSG00000024319
  
Biological name :Vps52
  
Synonyms : Q8C754 / Vps52 / VPS52 GARP complex subunit
  
Possible biological names infered from orthology : Q8N1B4
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 33955812
Gene end: 33966984
  
Corresponding Affymetrix probe sets: 10444114 (MoGene1.0st)   1437078_at (Mouse Genome 430 2.0 Array)   1447894_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025178
Ensembl peptide - ENSMUSP00000133926
NCBI entrez gene - 224705     See in Manteia.
MGI - MGI:1330304
RefSeq - XM_017317430
RefSeq - NM_172620
RefSeq - XM_006524107
RefSeq - XM_017317429
RefSeq Peptide - NP_766208
swissprot - G3UY33
swissprot - Q8C754
Ensembl - ENSMUSG00000024319
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vps52ENSDARG00000099258Danio rerio
 VPS52ENSG00000223501Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007258  Vps52


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006896 Golgi to vacuole transport IBA
 biological_processGO:0007041 lysosomal transport IEA
 biological_processGO:0010668 ectodermal cell differentiation IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0032456 endocytic recycling IEA
 biological_processGO:0042147 retrograde transport, endosome to Golgi IBA
 biological_processGO:0048611 embryonic ectodermal digestive tract development IMP
 cellular_componentGO:0000938 GARP complex IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0055037 recycling endosome ISS
 cellular_componentGO:1990745 EARP complex IEA
 molecular_functionGO:0017137 Rab GTPase binding IBA
 molecular_functionGO:0019905 syntaxin binding IEA


Pathways (from Reactome)
Pathway description
Retrograde transport at the Trans-Golgi-Network


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tab2tm2.1Aki/Tab2tm2.1Aki,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Vps52tm1.2Kab/tw5 Vps52t-w5
Genetic Background: involves: C57BL * C57BL/6 * CBA/JNCrlj * DBA

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Tab2tm2.1Aki/Tab2tm2.1Aki,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0001723 disorganized vascular plexus 
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Allelic Composition: Vps52tm1.1Kab/Vps52tm1.2Kab,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL * C57BL/6 * CBA * DBA

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vps52tm1.2Kab/tw5 Vps52t-w5
Genetic Background: involves: C57BL * C57BL/6 * CBA/JNCrlj * DBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vps52tm1.2Kab/tw5 Vps52t-w5
Genetic Background: involves: C57BL * C57BL/6 * CBA/JNCrlj * DBA

 MP:0003171 phenotypic reversion "reverse mutation to wild-type phenotype from a previously characterized mutant phenotype" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Vps52tm1.1Kab/Vps52tm1.2Kab,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL * C57BL/6 * CBA * DBA

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Vps52tm1.1Kab/Vps52tm1.2Kab,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL * C57BL/6 * CBA * DBA

 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tab2tm2.1Aki/Tab2tm2.1Aki,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vps52tm1.1Kab/Vps52tm1.2Kab,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL * C57BL/6 * CBA * DBA

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Vps52tm1.2Kab/tw5 Vps52t-w5
Genetic Background: involves: C57BL * C57BL/6 * CBA/JNCrlj * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020128 Vps54 / Q5SPW0 / VPS54 GARP complex subunit / Q9P1Q0*  / complex
 ENSMUSG00000024799 Q3UVL4 / Q71KT5 / Tm7sf2 / transmembrane 7 superfamily member 2 / VPS51* / Q9UID3* / VPS51, GARP complex subunit*  / complex
 ENSMUSG00000017288 Vps53 / Q8CCB4 / VPS53 GARP complex subunit / Q5VIR6*  / complex






 

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