ENSMUSG00000017756


Mus musculus

Features
Gene ID: ENSMUSG00000017756
  
Biological name :Slc12a7
  
Synonyms : Q9WVL3 / Slc12a7 / solute carrier family 12, member 7
  
Possible biological names infered from orthology : Q9Y666
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: C1
Gene start: 73733094
Gene end: 73816754
  
Corresponding Affymetrix probe sets: 10406111 (MoGene1.0st)   1418257_at (Mouse Genome 430 2.0 Array)   1449011_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152846
Ensembl peptide - ENSMUSP00000017900
NCBI entrez gene - 20499     See in Manteia.
MGI - MGI:1342283
RefSeq - XM_006517175
RefSeq - XM_006517171
RefSeq - XM_006517172
RefSeq - XM_006517173
RefSeq - XM_006517174
RefSeq - NM_011390
RefSeq - XM_006517170
RefSeq Peptide - NP_035520
swissprot - B9EIV8
swissprot - A0A1Y7VMP9
swissprot - Q9WVL3
Ensembl - ENSMUSG00000017756
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc12a7aENSDARG00000073756Danio rerio
 slc12a7bENSDARG00000062058Danio rerio
 SLC12A7ENSGALG00000042396Gallus gallus
 Q9Y666ENSG00000113504Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q91V14 / Slc12a5 / solute carrier family 12, member 5 / Q9H2X9*ENSMUSG0000001774074
Q9JIS8 / Slc12a4 / solute carrier family 12, member 4 / Q9UP95*ENSMUSG0000001776570
Q924N4 / Slc12a6 / Solute carrier family 12 member 6 / Q9UHW9*ENSMUSG0000002713069
Gm21985 / Q9UHW9* / SLC12A6* / solute carrier family 12 member 6*ENSMUSG0000009676467
Slc12a2 / solute carrier family 12 member 2 / P55011*ENSMUSG0000002459727
Slc12a1 / solute carrier family 12, member 1 / Q13621*ENSMUSG0000002720226
P59158 / Slc12a3 / Solute carrier family 12 member 3 / P55017*ENSMUSG0000003176625
Q99MR3 / Slc12a9 / Solute carrier family 12 member 9 / Q9BXP2*ENSMUSG0000003734421
Q8VI23 / Slc12a8 / solute carrier family 12 (potassium/chloride transporters), member 8 / A0AV02* / solute carrier family 12 member 8*ENSMUSG0000003550615


Protein motifs (from Interpro)
Interpro ID Name
 IPR000076  K/Cl co-transporter
 IPR004841  Amino acid permease/ SLC12A domain
 IPR004842  SLC12A transporter family
 IPR018491  SLC12A transporter, C-terminal
 IPR030354  K/Cl co-transporter 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006884 cell volume homeostasis IEA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IMP
 cellular_componentGO:0005886 plasma membrane IMP
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0015377 cation:chloride symporter activity IMP
 molecular_functionGO:0015379 potassium:chloride symporter activity IBA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
Cation-coupled Chloride cotransporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000026 abnormal inner ear morphology "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
Show

Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0000044 absent organ of Corti "absence of the highly specialized epithelium in the floor of the ductus cochlearis " [J:54408]
Show

Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0000525 renal tubular acidosis "a clinical syndrome characterized by the inability to acidify urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19268]
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Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Slc12a7mpc264H/Slc12a7mpc264H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0004403 absent cochlear outer hair cells "absence of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0009349 increased urine pH "increased urine alkalinity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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