Manteia - Molecule gene

ENSMUSG00000027130

Mus musculus

Features

Gene ID:	ENSMUSG00000027130

Biological name :	Slc12a6

Synonyms :	Q924N4 / Slc12a6 / Solute carrier family 12 member 6

Possible biological names infered from orthology :	Q9UHW9

Species:	Mus musculus

Chr. number:	2
Strand:	1
Band:	E3
Gene start:	112265825
Gene end:	112363163

Corresponding Affymetrix probe sets:	10474545 (MoGene1.0st) 1432798_at (Mouse Genome 430 2.0 Array) 1436989_s_at (Mouse Genome 430 2.0 Array) 1449878_a_at (Mouse Genome 430 2.0 Array) 1454359_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000028549 Ensembl peptide - ENSMUSP00000051490 Ensembl peptide - ENSMUSP00000106615 Ensembl peptide - ENSMUSP00000106619 NCBI entrez gene - 107723 See in Manteia. MGI - MGI:2135960 RefSeq - XM_006498546 RefSeq - NM_133648 RefSeq - NM_133649 RefSeq - XM_006498545 RefSeq Peptide - NP_598410 RefSeq Peptide - NP_598409 swissprot - Q3V0N8 swissprot - Q924N4 swissprot - A2AGJ9 Ensembl - ENSMUSG00000027130

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
si:cabz01090193.1	ENSDARG00000105485	Danio rerio
Q9UHW9	ENSG00000140199	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Gm21985 / Q9UHW9* / SLC12A6* / solute carrier family 12 member 6*	ENSMUSG00000096764	96
Q9JIS8 / Slc12a4 / solute carrier family 12, member 4 / Q9UP95*	ENSMUSG00000017765	72
Q91V14 / Slc12a5 / solute carrier family 12, member 5 / Q9H2X9*	ENSMUSG00000017740	66
Q9WVL3 / Slc12a7 / solute carrier family 12, member 7 / Q9Y666*	ENSMUSG00000017756	65
Slc12a2 / solute carrier family 12 member 2 / P55011*	ENSMUSG00000024597	25
Slc12a1 / solute carrier family 12, member 1 / Q13621*	ENSMUSG00000027202	24
P59158 / Slc12a3 / Solute carrier family 12 member 3 / P55017*	ENSMUSG00000031766	24
Q99MR3 / Slc12a9 / Solute carrier family 12 member 9 / Q9BXP2*	ENSMUSG00000037344	19
Q8VI23 / Slc12a8 / solute carrier family 12 (potassium/chloride transporters), member 8 / A0AV02* / solute carrier family 12 member 8*	ENSMUSG00000035506	14

Protein motifs (from Interpro)

Interpro ID	Name
IPR000076	K/Cl co-transporter
IPR000622	K/Cl co-transporter 1
IPR004841	Amino acid permease/ SLC12A domain
IPR004842	SLC12A transporter family
IPR018491	SLC12A transporter, C-terminal
IPR030364	K/Cl co-transporter 3

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006811	ion transport	ISO
biological_process	GO:0006813	potassium ion transport	IEA
biological_process	GO:0007268	chemical synaptic transmission	IBA
biological_process	GO:0010107	potassium ion import	ISO
biological_process	GO:0055085	transmembrane transport	IEA
biological_process	GO:0071476	cellular hypotonic response	ISO
biological_process	GO:0071477	cellular hypotonic salinity response	ISO
biological_process	GO:0071805	potassium ion transmembrane transport	IEA
biological_process	GO:1902476	chloride transmembrane transport	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005887	integral component of plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0016323	basolateral plasma membrane	IEA
cellular_component	GO:0030424	axon	IDA
molecular_function	GO:0005215	transporter activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0015079	potassium ion transmembrane transporter activity	ISO
molecular_function	GO:0015293	symporter activity	IEA
molecular_function	GO:0015377	cation:chloride symporter activity	IEA
molecular_function	GO:0015379	potassium:chloride symporter activity	ISS
molecular_function	GO:0019901	protein kinase binding	ISO

Pathways (from Reactome)

Pathway description

Cation-coupled Chloride cotransporters

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000043	organ of Corti degeneration	"a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0000231	hypertension	"sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0000746	weakness	"state of being infirm or less strong than littermates" [J:45400]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J
MP:0000780	abnormal corpus callosum morphology	"malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc12a6^tm1.1Garo/Slc12a6^tm1.1Garo Genetic Background: involves: 129 * C57BL/6
MP:0000781	reduced size of corpus callosum	"smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Slc12a6^tm1.1Garo/Slc12a6^tm1.1Garo Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Slc12a6^tm1Garo/Slc12a6^tm1Garo,Tg(Syn1-cre)671Jxm/0 Genetic Background: involves: 129 * C57BL/6 * CBA
MP:0000811	hippocampal neuron degeneration	"a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]	Show Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0000849	abnormal cerebellum morphology	"any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0000920	abnormal myelination	"atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pax3^Sp/Pax3⁺ Genetic Background: C57BL-Pax3^Sp Allelic Composition: Slc12a6^gaxp/Slc12a6^gaxp Genetic Background: C3H/HeSnJ-Slc12a6^gaxp/GrsrJ
MP:0000921	demyelination	"loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pax3^Sp/Pax3⁺ Genetic Background: C57BL-Pax3^Sp Allelic Composition: Slc12a6^tm1.1Garo/Slc12a6^tm1.1Garo Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Slc12a6^tm1Garo/Slc12a6^tm1Garo,Tg(Syn1-cre)671Jxm/0 Genetic Background: involves: 129 * C57BL/6 * CBA Allelic Composition: Slc12a6^em1Dlp/Slc12a6^em1Dlp Genetic Background: involves: C57BL/6J
MP:0000958	peripheral nervous system degeneration	"a retrogressive impairment of function or destruction of the ganglia and peripheral nerves that lie outside the brain and spinal cord" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0000961	abnormal dorsal root ganglia morphology	"malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]	Show Allelic Composition: Pvalb^tm1(cre)Arbr/Pvalb⁺,Slc12a6^tm2.1Dlp/Slc12a6^tm2.1Dlp Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Slc12a6^tm1.1Garo/Slc12a6^tm1.1Garo Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Slc12a6^tm1Garo/Slc12a6^tm1Garo,Tg(Syn1-cre)671Jxm/0 Genetic Background: involves: 129 * C57BL/6 * CBA
MP:0001392	abnormal locomotor activity	"altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Notch1^tm2Rko/Notch1^tm2Rko,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Slc12a6^tm1Garo/Slc12a6^tm1Garo,Tg(Syn1-cre)671Jxm/0 Genetic Background: involves: 129 * C57BL/6 * CBA
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Slc12a6^tm1.1Garo/Slc12a6^tm1.1Garo Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Slc12a6^tm1Garo/Slc12a6^tm1Garo,Tg(Syn1-cre)671Jxm/0 Genetic Background: involves: 129 * C57BL/6 * CBA
MP:0001405	impaired coordination	"reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pax3^Sp/Pax3⁺ Genetic Background: C57BL-Pax3^Sp Allelic Composition: Slc12a6^{Gt(OST458419)Lex}/Slc12a6^{Gt(OST458419)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J Allelic Composition: Slc12a6^tm1.1Garo/Slc12a6^tm1.1Garo Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Slc12a6^tm1Garo/Slc12a6^tm1Garo,Tg(Syn1-cre)671Jxm/0 Genetic Background: involves: 129 * C57BL/6 * CBA Allelic Composition: Pvalb^tm1(cre)Arbr/Pvalb⁺,Slc12a6^tm2.1Dlp/Slc12a6^tm2.1Dlp Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J Allelic Composition: Slc12a6^em1Dlp/Slc12a6^em1Dlp Genetic Background: involves: C57BL/6J
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Slc12a6^{Gt(OST458419)Lex}/Slc12a6^{Gt(OST458419)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0001417	decreased exploration in new environment	"less amount of time spent investigating a new location" [J:79870]	Show Allelic Composition: Pax3^Sp/Pax3⁺ Genetic Background: C57BL-Pax3^Sp Allelic Composition: Slc12a6^{Gt(OST458419)Lex}/Slc12a6^{Gt(OST458419)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J Allelic Composition: Slc12a6^tm1Dlp/Slc12a6⁺ Genetic Background: involves: 129 * C57BL/6J
MP:0001486	abnormal startle reflex	"abberant threshold or reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]	Show Allelic Composition: Slc12a6^tm1.1Garo/Slc12a6^tm1.1Garo Genetic Background: involves: 129 * C57BL/6
MP:0001506	limp posture	"lack of rigidity of the carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]	Show Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0001513	limb grasping	"mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Pax3^Sp/Pax3⁺ Genetic Background: C57BL-Pax3^Sp Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Slc12a6^tm1.1Garo/Slc12a6^tm1.1Garo Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Slc12a6^tm1Garo/Slc12a6^tm1Garo,Tg(Syn1-cre)671Jxm/0 Genetic Background: involves: 129 * C57BL/6 * CBA
MP:0001524	impaired limb coordination	"reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]	Show Allelic Composition: Pax3^Sp/Pax3⁺ Genetic Background: C57BL-Pax3^Sp
MP:0001924	infertility	"inability to produce live offspring" [J:47225]	Show Allelic Composition: Pax3^Sp/Pax3⁺ Genetic Background: C57BL-Pax3^Sp Allelic Composition: Slc12a6^tm1.1Garo/Slc12a6^tm1.1Garo Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Slc12a6^tm1Garo/Slc12a6^tm1Garo,Tg(Syn1-cre)671Jxm/0 Genetic Background: involves: 129 * C57BL/6 * CBA
MP:0001967	deafness	"inability to hear" [J:57651]	Show Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0002152	abnormal brain morphology	"anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]	Show Allelic Composition: Galc^twi/Galc^twi Genetic Background: B6.CE-Galc^twi/J
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Notch1^tm2Rko/Notch1^tm2Rko,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0002176	high brain weight	"greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc12a6^tm1.1Garo/Slc12a6^tm1.1Garo Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Slc12a6^tm1Garo/Slc12a6^tm1Garo,Tg(Syn1-cre)671Jxm/0 Genetic Background: involves: 129 * C57BL/6 * CBA
MP:0002229	CNS neurodegeneration	"a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0002651	abnormal sciatic nerve	"malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pax3^Sp/Pax3⁺ Genetic Background: C57BL-Pax3^Sp Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Slc12a6^tm1.1Garo/Slc12a6^tm1.1Garo Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Slc12a6^tm1Garo/Slc12a6^tm1Garo,Tg(Syn1-cre)671Jxm/0 Genetic Background: involves: 129 * C57BL/6 * CBA
MP:0002690	akinesia	"absence of movement or loss of the ability to move such as temporary or prolonged paralysis or "freezing in place"" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:82238]	Show Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0002857	cochlear ganglion degeneration	"loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0002906	susceptibility to pharmacologically induced seizures	"inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]	Show Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0003063	increased coping response	"enhanced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]	Show Allelic Composition: Slc12a6^{Gt(OST458419)Lex}/Slc12a6^{Gt(OST458419)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0003225	axonal dystrophy	"axon degeneration resulting from inadequate or faulty metabolism" [RGD:Rat Genome Database submission]	Show Allelic Composition: Slc12a6^gaxp/Slc12a6^gaxp Genetic Background: C3H/HeSnJ-Slc12a6^gaxp/GrsrJ
MP:0003632	abnormal nervous system morphology		Show Allelic Composition: Slc12a6^tm1.1Garo/Slc12a6^tm1.1Garo Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Slc12a6^tm1Garo/Slc12a6^tm1Garo,Tg(Syn1-cre)671Jxm/0 Genetic Background: involves: 129 * C57BL/6 * CBA
MP:0003871	abnormal myelin sheath morphology	"malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Pax3^Sp/Pax3⁺ Genetic Background: C57BL-Pax3^Sp
MP:0004143	hypertonia	"increased muscle tone" [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0004262	abnormal physical strength	"altered ability of an organism to exert force on physical objects or of the body to support its load" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc12a6^{Gt(OST458419)Lex}/Slc12a6^{Gt(OST458419)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0004263	abnormal limb posture	"atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax3^Sp/Pax3⁺ Genetic Background: C57BL-Pax3^Sp Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0004268	abnormal optic stalk morphology	"any structural anomaly of the narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain" [ISBN:0-914294-08-3 "Gray s Anatomy"]	Show Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0004362	cochlear hair cell degeneration	"degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0004398	cochlear inner hair cell degeneration	"degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0004404	cochlear outer hair cell degeneration	"degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0004411	decreased endocochlear potential	"reduction of the electrical potential difference between the endolymphatic and perilymphatic compartments of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0004487	type I spiral ligament fibrocyte degeneration	"degeneration or loss of type I spiral ligament fibrocytes which occupy the region beneath the stria vascularis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0004489	type III spiral ligament fibrocyte degeneration	"degeneration or loss of type III spiral ligament fibrocytes which form a cell layer attached to the otic capsule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0004740	sensorineural hearing loss	"a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0005403	abnormal nerve conduction	"anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Slc12a6^em1Dlp/Slc12a6^em1Dlp Genetic Background: involves: C57BL/6J
MP:0005404	abnormal axon morphology	"anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pax3^Sp/Pax3⁺ Genetic Background: C57BL-Pax3^Sp Allelic Composition: Slc12a6^gaxp/Slc12a6^gaxp Genetic Background: C3H/HeSnJ-Slc12a6^gaxp/GrsrJ Allelic Composition: Slc12a6^tm1.1Garo/Slc12a6^tm1.1Garo Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Slc12a6^tm1Garo/Slc12a6^tm1Garo,Tg(Syn1-cre)671Jxm/0 Genetic Background: involves: 129 * C57BL/6 * CBA
MP:0005405	axon degeneration	"retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pax3^Sp/Pax3⁺ Genetic Background: C57BL-Pax3^Sp Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Slc12a6^tm1.1Garo/Slc12a6^tm1.1Garo Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Slc12a6^tm1Garo/Slc12a6^tm1Garo,Tg(Syn1-cre)671Jxm/0 Genetic Background: involves: 129 * C57BL/6 * CBA
MP:0005621	abnormal cell physiology	"aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0008532	decreased chemical nociceptive threshold	"a lower than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc12a6^tm1.1Garo/Slc12a6^tm1.1Garo Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Slc12a6^tm1Garo/Slc12a6^tm1Garo,Tg(Syn1-cre)671Jxm/0 Genetic Background: involves: 129 * C57BL/6 * CBA
MP:0009142	decreased prepulse inhibition	"decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax3^Sp/Pax3⁺ Genetic Background: C57BL-Pax3^Sp Allelic Composition: Slc12a6^tm1Dlp/Slc12a6⁺ Genetic Background: involves: 129 * C57BL/6J
MP:0009434	paraparesis	"a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax3^Sp/Pax3⁺ Genetic Background: C57BL-Pax3^Sp Allelic Composition: Slc12a6^gaxp/Slc12a6^gaxp Genetic Background: C3H/HeSnJ-Slc12a6^gaxp/GrsrJ
MP:0012712	spinal cord degeneration	"a retrogressive impairment of function or destruction of the spinal cord" [MGI:anna]	Show Allelic Composition: Slc12a6^tm1Tjj/Slc12a6^tm1Tjj Genetic Background: involves: 129/Sv * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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