ENSMUSG00000027202


Mus musculus

Features
Gene ID: ENSMUSG00000027202
  
Biological name :Slc12a1
  
Synonyms : Slc12a1 / solute carrier family 12, member 1
  
Possible biological names infered from orthology : Q13621
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F1
Gene start: 125152505
Gene end: 125230002
  
Corresponding Affymetrix probe sets: 10475580 (MoGene1.0st)   1421390_at (Mouse Genome 430 2.0 Array)   1424260_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028630
Ensembl peptide - ENSMUSP00000106121
Ensembl peptide - ENSMUSP00000106120
NCBI entrez gene - 20495     See in Manteia.
MGI - MGI:103150
RefSeq - NM_183354
RefSeq - NM_001079690
RefSeq Peptide - NP_899197
RefSeq Peptide - NP_001073158
swissprot - A2AQ51
swissprot - A2AQ52
swissprot - A2AQ50
Ensembl - ENSMUSG00000027202
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc12a1ENSDARG00000098096Danio rerio
 SLC12A1ENSGALG00000004945Gallus gallus
 Q13621ENSG00000074803Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc12a2 / solute carrier family 12 member 2 / P55011*ENSMUSG0000002459764
P59158 / Slc12a3 / Solute carrier family 12 member 3 / P55017*ENSMUSG0000003176649
Q9JIS8 / Slc12a4 / solute carrier family 12, member 4 / Q9UP95*ENSMUSG0000001776526
Q924N4 / Slc12a6 / Solute carrier family 12 member 6 / Q9UHW9*ENSMUSG0000002713026
Q9WVL3 / Slc12a7 / solute carrier family 12, member 7 / Q9Y666*ENSMUSG0000001775625
Q91V14 / Slc12a5 / solute carrier family 12, member 5 / Q9H2X9*ENSMUSG0000001774025
Gm21985 / Q9UHW9* / SLC12A6* / solute carrier family 12 member 6*ENSMUSG0000009676424
Q99MR3 / Slc12a9 / Solute carrier family 12 member 9 / Q9BXP2*ENSMUSG0000003734422
Q8VI23 / Slc12a8 / solute carrier family 12 (potassium/chloride transporters), member 8 / A0AV02* / solute carrier family 12 member 8*ENSMUSG0000003550616


Protein motifs (from Interpro)
Interpro ID Name
 IPR002443  Na/K/Cl co-transporter
 IPR002445  Solute carrier family 12 member 1
 IPR004841  Amino acid permease/ SLC12A domain
 IPR004842  SLC12A transporter family
 IPR013612  Amino acid permease, N-terminal
 IPR018491  SLC12A transporter, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0015377 cation:chloride symporter activity IEA


Pathways (from Reactome)
Pathway description
Cation-coupled Chloride cotransporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Tmprss6tm1Dgen/Tmprss6+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000192 abnormal mineral level "anomalous concentration of any inorganic substance that has importance in body functions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cacnb2tm1Rgg/Cacnb2tm1Rgg
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tmprss6tm1Dgen/Tmprss6+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: C3HeB/FeJ-Slc12a1urehr3

Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Tmprss6tm1Dgen/Tmprss6+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: C3HeB/FeJ-Slc12a1urehr3

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: C3HeB/FeJ-Slc12a1urehr3

Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0001771 abnormal circulating magnesium level "anomalous blood concentration of this bioelement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxb1tm1Lby/Foxb1tm1Lby
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001784 abnormal fluid regulation "anomalous control of intracellular and/or extracellular fluid " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: C3HeB/FeJ-Slc12a1urehr3

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: C3HeB/FeJ-Slc12a1urehr3

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Foxb1tm1Lby/Foxb1tm1Lby
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Slc12a1tm1Haca/Slc12a1tm1Haca
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003020 decreased circulating chloride level "reduced concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: C3HeB/FeJ-Slc12a1urehr3

Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0003028 alkalosis "a pathological condition characterized by a decrease in the hydrogen ion concentration of arterial blood; caused by an increase in the concentration of alkaline compounds, or by a decrease in the concentration of acidic compounds or carbon dioxide to the body fluids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0003197 kidney calcification "pathologic deposition of calcium salts in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: C3HeB/FeJ-Slc12a1urehr3

Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0003352 increased circulating renin level "elevated blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Foxb1tm1Lby/Foxb1tm1Lby
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0003353 decreased circulating renin level "reduced blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Slc12a1tm1Haca/Slc12a1tm1Haca
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003653 decreased skin turgor "reduced ability of the skin to resist deformation; influential factors include dehydration and age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003795 abnormal bone structure 
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0005441 hypercalciuria "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0005522 increased circulating atrial natriuretic factor "greater than the normal concentration of this peptide hormone in the blood; it regulates the water-electrolyte balance and acts as a vasodilator" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: C3HeB/FeJ-Slc12a1urehr3

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0005557 increased creatinine clearance "greater than the normal amount of this creatine metabolite filtered by the kidneys in a specific period of time; indicative of kidney function" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: C3HeB/FeJ-Slc12a1urehr3

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: C3HeB/FeJ-Slc12a1urehr3

Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0005568 increased circulating total protein level "greater than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005582 increased renin activity "greater than the normal ability of this enzyme to cleave angiotensinogen and create angiotensin I" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005619 increased potassium excretion "greater than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: C3HeB/FeJ-Slc12a1urehr3

 MP:0008055 increased urine osmolality "increase in the concentration of ions in the urine compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0010092 increased circulating magnesium level "an elevation in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0010107 abnormal renal reabsorption "any anomaly in the two-step process beginning with the active or passive extraction of substances (such as water, glucose, oligopeptides, amino acids, sodium (Na+) and other ions) from the renal tubule fluid into the renal interstitium, and the subsequent transport of these substances out of the renal interstitium back into the bloodstream; reabsorption begins in the proximal convoluted tubules and continues in the loop of Henle, distal convoluted tubules, and collecting tubules" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxb1tm1Lby/Foxb1tm1Lby
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0010108 abnormal renal water reabsorption "any anomaly in the process by which water is passively transported out of the renal tubules back into the bloodstream" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxb1tm1Lby/Foxb1tm1Lby
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011295 abnormal tubuloglomerular feedback response "any anomaly in the blood flow control mechanism that is operated in the juxtaglomerular apparatus of the kidney and involved in renal autoregulation by limiting changes in the glomerular filtration rate. TGF responds to changes in the concentration of NaCl in the tubular fluid at the level of the macula densa" [MGI:anna]
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Allelic Composition: Foxb1tm1Lby/Foxb1tm1Lby
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Slc12a1tm1Haca/Slc12a1tm1Haca
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0011296 decreased tubuloglomerular feedback response "attenuation of the blood flow control mechanism that is operated in the juxtaglomerular apparatus of the kidney and involved in renal autoregulation by limiting changes in the glomerular filtration rate. TGF responds to changes in the concentration of NaCl in the tubular fluid at the level of the macula densa" [MGI:anna]
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Allelic Composition: Foxb1tm1Lby/Foxb1tm1Lby
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0011304 kidney papillary atrophy "acquired diminution of the size of the apex (tip) of a renal pyramid associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: C3HeB/FeJ-Slc12a1urehr3

Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0011403 pyelonephritis "a diffuse pyogenic infection of the pelvis and parenchyma of the kidney; an ascending urinary tract infection that has reached the pyelum or pelvis of the kidney usually resulting from noncontagious bacterial infection of the bladder" [MGI:anna]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0011404 pyelitis "acute inflammation of the pelvis of the kidney, caused by bacterial infection" [MGI:anna]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0011424 decreased urine uric acid level "abnormally low amount in the urine of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MGI:anna]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0011435 increased urine magnesium level "higher than normal amount of magnesium in the urine" [MGI:anna]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0011465 abnormal urine urea nitrogen level "any change in the amount of nitrogen in the form of urea in the urine" [MGI:csmith]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0011470 increased urine creatinine level "an increased amount of creatinine in the urine compared to the normal state" [MGI:csmith]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0011471 decreased urine creatinine level "a reduced amount of creatinine in the urine compared to the normal state" [MGI:csmith]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: C3HeB/FeJ-Slc12a1urehr3

 MP:0011563 increased urine prostaglandin level "a greater amount of any prostaglandin in the urine compared to the normal state" [MGI:anna]
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Allelic Composition: Slc12a1urehr3/Slc12a1urehr3
Genetic Background: involves: C3HeB/FeJ

 MP:0012551 metabolic acidosis "decreased pH and bicarbonate concentration in tissues and/or body fluids caused when the body produces too much acid or when the kidneys are not removing enough acid from the body, as in diarrhea or in kidney disease" [ISBN:0-683-40008-8]
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Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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