ENSMUSG00000031766


Mus musculus

Features
Gene ID: ENSMUSG00000031766
  
Biological name :Slc12a3
  
Synonyms : P59158 / Slc12a3 / Solute carrier family 12 member 3
  
Possible biological names infered from orthology : P55017
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C5
Gene start: 94329201
Gene end: 94366214
  
Corresponding Affymetrix probe sets: 10574059 (MoGene1.0st)   1422856_at (Mouse Genome 430 2.0 Array)   1446552_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148537
Ensembl peptide - ENSMUSP00000034218
Ensembl peptide - ENSMUSP00000148455
NCBI entrez gene - 20497     See in Manteia.
MGI - MGI:108114
RefSeq - XM_017312626
RefSeq - NM_001205311
RefSeq - NM_019415
RefSeq - XM_017312625
RefSeq Peptide - NP_001192240
RefSeq Peptide - NP_062288
swissprot - P59158
swissprot - A0A1D5RLX1
swissprot - Q543E4
swissprot - A0A1D5RLP7
Ensembl - ENSMUSG00000031766
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc12a3ENSDARG00000013855Danio rerio
 SLC12A3ENSGALG00000002957Gallus gallus
 P55017ENSG00000070915Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc12a2 / solute carrier family 12 member 2 / P55011*ENSMUSG0000002459753
Slc12a1 / solute carrier family 12, member 1 / Q13621*ENSMUSG0000002720253
Q9JIS8 / Slc12a4 / solute carrier family 12, member 4 / Q9UP95*ENSMUSG0000001776527
Q9WVL3 / Slc12a7 / solute carrier family 12, member 7 / Q9Y666*ENSMUSG0000001775627
Q924N4 / Slc12a6 / Solute carrier family 12 member 6 / Q9UHW9*ENSMUSG0000002713027
Q91V14 / Slc12a5 / solute carrier family 12, member 5 / Q9H2X9*ENSMUSG0000001774027
Gm21985 / Q9UHW9* / SLC12A6* / solute carrier family 12 member 6*ENSMUSG0000009676426
Q99MR3 / Slc12a9 / Solute carrier family 12 member 9 / Q9BXP2*ENSMUSG0000003734422
Q8VI23 / Slc12a8 / solute carrier family 12 (potassium/chloride transporters), member 8 / A0AV02* / solute carrier family 12 member 8*ENSMUSG0000003550617


Protein motifs (from Interpro)
Interpro ID Name
 IPR002948  Thiazide-sensitive Na-K-Cl co-transporter
 IPR004841  Amino acid permease/ SLC12A domain
 IPR004842  SLC12A transporter family
 IPR013612  Amino acid permease, N-terminal
 IPR018491  SLC12A transporter, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0015377 cation:chloride symporter activity IEA


Pathways (from Reactome)
Pathway description
Cation-coupled Chloride cotransporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rpe65rd12/Rpe65rd12
Genetic Background: B6(A)-Rpe65rd12/J

 MP:0002986 hypocalciuria "excretion of abnormally low amounts of calcium in the urine" [J:83000]
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Allelic Composition: Rpe65rd12/Rpe65rd12
Genetic Background: B6(A)-Rpe65rd12/J

 MP:0004757 abnormal distal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron between the ascending portion of the loop of Henle and the collecting duct system in the kidney cortex; it is partly responsible for the regulation of potassium, sodium, calcium, and pH through the endocrine system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rpe65rd12/Rpe65rd12
Genetic Background: B6(A)-Rpe65rd12/J

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp4tm5.1Bhr/Bmp4tm2.1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp4tm5.1Bhr/Bmp4tm2.1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster

 MP:0010093 decreased circulating magnesium level "a reduction in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Rpe65rd12/Rpe65rd12
Genetic Background: B6(A)-Rpe65rd12/J

 MP:0011442 abnormal renal sodium ion transport "any anomaly in the directed movement of sodium ions (Na+) by the kidney" [GO:0003096]
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Allelic Composition: Bmp4tm5.1Bhr/Bmp4tm2.1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster

 MP:0011460 decreased urine chloride ion level "abnormally low amounts of chloride ion in the urine" [MGI:csmith]
Show

Allelic Composition: Bmp4tm5.1Bhr/Bmp4tm2.1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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