ENSMUSG00000020067


Mus musculus

Features
Gene ID: ENSMUSG00000020067
  
Biological name :Mypn
  
Synonyms : Myopalladin / Mypn / Q5DTJ9
  
Possible biological names infered from orthology : Q86TC9
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B4
Gene start: 63115795
Gene end: 63203952
  
Corresponding Affymetrix probe sets: 10369715 (MoGene1.0st)   1435813_at (Mouse Genome 430 2.0 Array)   1441551_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151637
Ensembl peptide - ENSMUSP00000093240
NCBI entrez gene - 68802     See in Manteia.
MGI - MGI:1916052
RefSeq - NM_182992
RefSeq Peptide - NP_892037
swissprot - A0A1W2P7G1
swissprot - Q5DTJ9
Ensembl - ENSMUSG00000020067
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MYPNENSGALG00000003925Gallus gallus
 MYPNENSG00000138347Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Palld / Q9ET54 / Palladin / Q8WX93* / palladin, cytoskeletal associated protein*ENSMUSG0000005805644
Ttn / titin / A2ASS6 / Q8WZ42*ENSMUSG0000005174728
Hmcn2 / A2AJ76 / Hemicentin-2 / Q8NDA2*ENSMUSG0000005563216
Hmcn1 / D3YXG0 / Hemicentin-1 / Q96RW7*ENSMUSG0000006684216
Obscn / obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF / Q5VST9*ENSMUSG0000006146213
Myot / Q9JIF9 / myotilin / Q9UBF9*ENSMUSG0000002447112
Igsf10 / Q3V1M1 / Immunoglobulin superfamily member 10 / Q6WRI0*ENSMUSG0000003633411
Obsl1 / D3YYU8 / Obscurin-like protein 1 / O75147* / obscurin like 1*ENSMUSG000000262112


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030334 regulation of cell migration IBA
 biological_processGO:0045214 sarcomere organization IEA
 biological_processGO:0048739 cardiac muscle fiber development IBA
 biological_processGO:0051493 regulation of cytoskeleton organization IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030017 sarcomere IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0031674 I band IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0051015 actin filament binding IBA
 molecular_functionGO:0051371 muscle alpha-actinin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Atp6v1b1vtx/Atp6v1b1vtx
Genetic Background: B6.MRL-Atp6v1b1vtx/Kjn

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
Show

Allelic Composition: Atp6v1b1vtx/Atp6v1b1vtx
Genetic Background: B6.MRL-Atp6v1b1vtx/Kjn

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp6v1b1vtx/Atp6v1b1vtx
Genetic Background: B6.MRL-Atp6v1b1vtx/Kjn

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp6v1b1vtx/Atp6v1b1vtx
Genetic Background: B6.MRL-Atp6v1b1vtx/Kjn

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp6v1b1vtx/Atp6v1b1vtx
Genetic Background: B6.MRL-Atp6v1b1vtx/Kjn

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp6v1b1vtx/Atp6v1b1vtx
Genetic Background: B6.MRL-Atp6v1b1vtx/Kjn

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Atp6v1b1vtx/Atp6v1b1vtx
Genetic Background: B6.MRL-Atp6v1b1vtx/Kjn

 MP:0006267 abnormal intercalated disc morphology "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280]
Show

Allelic Composition: Atp6v1b1vtx/Atp6v1b1vtx
Genetic Background: B6.MRL-Atp6v1b1vtx/Kjn

 MP:0010505 abnormal T wave "any anomaly in the T wave which is normally caused by the repolarization (or recovery) of the ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp6v1b1vtx/Atp6v1b1vtx
Genetic Background: B6.MRL-Atp6v1b1vtx/Kjn

 MP:0010519 atrioventricular block "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Atp6v1b1vtx/Atp6v1b1vtx
Genetic Background: B6.MRL-Atp6v1b1vtx/Kjn

 MP:0011925 abnormal heart echocardiography feature "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
Show

Allelic Composition: Atp6v1b1vtx/Atp6v1b1vtx
Genetic Background: B6.MRL-Atp6v1b1vtx/Kjn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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