ENSMUSG00000061462


Mus musculus

Features
Gene ID: ENSMUSG00000061462
  
Biological name :Obscn
  
Synonyms : Obscn / obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
  
Possible biological names infered from orthology : Q5VST9
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 58994256
Gene end: 59136402
  
Corresponding Affymetrix probe sets: 10386238 (MoGene1.0st)   10386262 (MoGene1.0st)   1443632_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116487
Ensembl peptide - ENSMUSP00000120128
Ensembl peptide - ENSMUSP00000121092
Ensembl peptide - ENSMUSP00000122181
Ensembl peptide - ENSMUSP00000151217
Ensembl peptide - ENSMUSP00000020732
Ensembl peptide - ENSMUSP00000038264
Ensembl peptide - ENSMUSP00000049737
NCBI entrez gene - 380698     See in Manteia.
MGI - MGI:2681862
RefSeq - NM_001171512
RefSeq - NM_199152
RefSeq Peptide - NP_001164983
RefSeq Peptide - NP_954603
swissprot - Z4YJE4
swissprot - A0A1W2P6H1
swissprot - E9QQ96
swissprot - F6TJX7
swissprot - F6X8F4
swissprot - F7DCJ0
swissprot - H7BX05
swissprot - J9JIB2
Ensembl - ENSMUSG00000061462
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 obscnbENSDARG00000022101Danio rerio
 OBSCNENSGALG00000032534Gallus gallus
 OBSCNENSG00000154358Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ttn / titin / A2ASS6 / Q8WZ42*ENSMUSG0000005174716
Hmcn2 / A2AJ76 / Hemicentin-2 / Q8NDA2*ENSMUSG0000005563212
Hmcn1 / D3YXG0 / Hemicentin-1 / Q96RW7*ENSMUSG0000006684212
Obsl1 / D3YYU8 / Obscurin-like protein 1 / O75147* / obscurin like 1*ENSMUSG000000262117
Igsf10 / Q3V1M1 / Immunoglobulin superfamily member 10 / Q6WRI0*ENSMUSG000000363344
Mypn / Q5DTJ9 / Myopalladin / Q86TC9*ENSMUSG000000200672
Palld / Q9ET54 / Palladin / Q8WX93* / palladin, cytoskeletal associated protein*ENSMUSG000000580562
Myot / Q9JIF9 / myotilin / Q9UBF9*ENSMUSG000000244711


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000219  Dbl homology (DH) domain
 IPR000719  Protein kinase domain
 IPR001849  Pleckstrin homology domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR015726  Serine/threonine protein kinase, striated muscle-specific
 IPR017441  Protein kinase, ATP binding site
 IPR035526  Obscurin, SH3 domain
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0030017 sarcomere IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0031430 M band IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
Show

Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0004088 abnormal sarcoplasmic reticulum morphology "any structural abnormality in the endoplasmic reticulum of skeletal and cardiac muscle, i.e. the complex of vesicles, tubules, and cisternae that form a continuous structure around striated myofibrils, with a repetition of structure within each sarcomere " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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