ENSDARG00000022101


Danio rerio

Features
Gene ID: ENSDARG00000022101
  
Biological name :obscnb
  
Synonyms : obscnb / obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b
  
Possible biological names infered from orthology : OBSCN / obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF / Q5VST9
  
Species: Danio rerio
  
Chr. number: 24
Strand: 1
Band:
Gene start: 35933869
Gene end: 36002202
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000142063
Ensembl peptide - ENSDARP00000142069
Ensembl peptide - ENSDARP00000142503
Ensembl peptide - ENSDARP00000129075
swissprot - A0A140LFP0
swissprot - A0A140LFP6
swissprot - A0A140LGX4
swissprot - X1WFS0
ZFIN ID - ZDB-GENE-070119-5
Ensembl - ENSDARG00000022101
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 OBSCNENSGALG00000032534Gallus gallus
 OBSCNENSG00000154358Homo sapiens
 ObscnENSMUSG00000061462Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ttn.1 / titin, tandem duplicate 1 / TTN* / titin* / A2ASS6* / Q8WZ42*ENSDARG0000000056322
obsl1b / obscurin-like 1b / OBSL1* / D3YYU8* / O75147* / obscurin like 1* / Obscurin-like protein 1 *ENSDARG0000007738822
ttn.2 / titin, tandem duplicate 2 / TTN* / titin* / A2ASS6* / Q8WZ42*ENSDARG0000002821322
hmcn1 / hemicentin 1 / D3YXG0* / Q96RW7*ENSDARG0000001693619
obsl1a / obscurin-like 1a / OBSL1* / O75147* / obscurin like 1*ENSDARG0000000368418
hmcn2 / hemicentin 2 / A2AJ76* / Q8NDA2*ENSDARG0000007932710
igsf10 / immunoglobulin superfamily, member 10 / Q3V1M1* / Q6WRI0*ENSDARG000000774976
mxra5b / matrix-remodelling associated 5b / MXRA5* / Q9NR99* / matrix remodeling associated 5*ENSDARG000000763095
mxra5a / matrix-remodelling associated 5a / MXRA5* / Q9NR99* / matrix remodeling associated 5*ENSDARG000000748154
si:ch211-159i8.4ENSDARG000000763324
palld / palladin, cytoskeletal associated protein / Q8WX93* / Q9ET54* / Palladin *ENSDARG000000400093
CU928131.1ENSDARG000001092623
hmcn2 / hemicentin 2ENSDARG000000860600
myot / myotilinENSDARG000000763120


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000219  Dbl homology (DH) domain
 IPR001452  SH3 domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR035526  Obscurin, SH3 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030239 myofibril assembly IMP
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0055002 striated muscle cell development IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0031430 M band IDA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle decreased size , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye hypoplastic , abnormal
Show

 ZFA:0000114 heart heart dilated , abnormal
heart decreased functionality , abnormal
heart structure , abnormal
heart decreased size , abnormal
Show

 ZFA:0000610 vertical myoseptum vertical myoseptum disorganized , abnormal
vertical myoseptum morphology , abnormal
vertical myoseptum decreased size , abnormal
Show

 ZFA:0000671 horizontal myoseptum horizontal myoseptum aplastic , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
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 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region decreased width , abnormal
Show

 ZFA:0001202 optic cup optic cup morphology , abnormal
Show

 ZFA:0001617 otolith otolith decreased amount , abnormal
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 ZFA:0009115 skeletal muscle cell skeletal muscle cell nucleus shape , abnormal
skeletal muscle cell myofibril decreased amount , abnormal
skeletal muscle cell sarcomere structure , abnormal
skeletal muscle cell Z disc structure , abnormal
skeletal muscle cell M band decreased amount , abnormal
skeletal muscle cell elongated , abnormal
skeletal muscle cell sarcoplasmic reticulum disorganized , abnormal
skeletal muscle cell myofibril disorganized , abnormal
skeletal muscle cell striated muscle myosin thick filament disorganized , abnormal
skeletal muscle cell myofibril orientation skeletal muscle cell , abnormal
Show

 ZFA:0009127 photoreceptor cell photoreceptor cell absent , abnormal
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 ZFA:0009316 cardiac muscle cell cardiac muscle cell structure , abnormal
cardiac muscle cell intercalated disc absent , abnormal
cardiac muscle cell myofibril decreased amount , abnormal
cardiac muscle cell myofibril disorganized , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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