ENSDARG00000028213


Danio rerio

Features
Gene ID: ENSDARG00000028213
  
Biological name :ttn.2
  
Synonyms : titin, tandem duplicate 2 / ttn.2
  
Possible biological names infered from orthology : A2ASS6 / Q8WZ42 / titin / TTN
  
Species: Danio rerio
  
Chr. number: 9
Strand: -1
Band:
Gene start: 42894845
Gene end: 43073960
  
Corresponding Affymetrix probe sets: Dr.20990.1.S1_at (Zebrafish Array)   Dr.20990.2.S1_at (Zebrafish Array)   Dr.4681.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000105577
Ensembl peptide - ENSDARP00000112776
Ensembl peptide - ENSDARP00000059459
Ensembl peptide - ENSDARP00000099532
swissprot - B0S757
swissprot - B0S758
swissprot - F1QZQ0
swissprot - F1R7N8
ZFIN ID - ZDB-GENE-030113-2
Ensembl - ENSDARG00000028213
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TTNENSG00000155657Homo sapiens
 TtnENSMUSG00000051747Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ttn.1 / titin, tandem duplicate 1 / TTN* / titin* / A2ASS6* / Q8WZ42*ENSDARG0000000056365
hmcn1 / hemicentin 1 / D3YXG0* / Q96RW7*ENSDARG000000169363
obsl1b / obscurin-like 1b / OBSL1* / D3YYU8* / O75147* / obscurin like 1* / Obscurin-like protein 1 *ENSDARG000000773882
hmcn2 / hemicentin 2 / A2AJ76* / Q8NDA2*ENSDARG000000793272
CU928131.1ENSDARG000001092621
obscnb / obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b / OBSCN* / Q5VST9* / obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF*ENSDARG000000221011
palld / palladin, cytoskeletal associated protein / Q8WX93* / Q9ET54* / Palladin *ENSDARG000000400091
igsf10 / immunoglobulin superfamily, member 10 / Q3V1M1* / Q6WRI0*ENSDARG000000774971
si:ch211-159i8.4ENSDARG000000763321
obsl1a / obscurin-like 1a / OBSL1* / O75147* / obscurin like 1*ENSDARG000000036841
mxra5a / matrix-remodelling associated 5a / MXRA5* / Q9NR99* / matrix remodeling associated 5*ENSDARG000000748151
mxra5b / matrix-remodelling associated 5b / MXRA5* / Q9NR99* / matrix remodeling associated 5*ENSDARG000000763091
hmcn2 / hemicentin 2ENSDARG000000860600
myot / myotilinENSDARG000000763120


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR005819  Histone H5
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0006334 nucleosome assembly IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006941 striated muscle contraction IBA
 biological_processGO:0007015 actin filament organization IBA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007519 skeletal muscle tissue development IMP
 biological_processGO:0030239 myofibril assembly IGI
 biological_processGO:0045214 sarcomere organization IMP
 biological_processGO:0048738 cardiac muscle tissue development IMP
 biological_processGO:0048769 sarcomerogenesis IMP
 biological_processGO:0060047 heart contraction IMP
 biological_processGO:0071688 striated muscle myosin thick filament assembly IGI
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0005859 muscle myosin complex IBA
 cellular_componentGO:0030018 Z disc IBA
 cellular_componentGO:0031430 M band IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008307 structural constituent of muscle IMP
 molecular_functionGO:0051015 actin filament binding IBA
 molecular_functionGO:0051371 muscle alpha-actinin binding IBA
 molecular_functionGO:0097493 structural molecule activity conferring elasticity IBA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Striated Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle contractility , abnormal
cardiac ventricle decreased size , abnormal
Show

 ZFA:0000037 anatomical structure anatomical structure decreased amount , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000114 heart heart quality , abnormal
heart edematous , abnormal
heart decreased contractility , abnormal
heart decreased strength , abnormal
heart dilated , abnormal
Show

 ZFA:0000155 somite somite grey , abnormal
somite myofibril disorganized , abnormal
somite sarcomere spatial pattern , abnormal
somite sarcomere decreased length , abnormal
somite sarcomere disorganized , abnormal
somite Z disc spatial pattern , abnormal
somite Z disc disorganized , abnormal
Show

 ZFA:0000471 atrium atrium contractility , abnormal
Show

 ZFA:0001094 whole organism whole organism paralysed , abnormal
whole organism decreased behavioural activity , abnormal
whole organism decreased life span , abnormal
whole organism edematous , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0005145 muscle muscle structure , abnormal
Show

 ZFA:0005277 skeletal muscle skeletal muscle quality , abnormal
skeletal muscle sarcomere disorganized , abnormal
Show

 ZFA:0005280 cardiac muscle cardiac muscle sarcomere disorganized , abnormal
Show

 ZFA:0009053 sensory neuron sensory neuron morphology , abnormal
sensory neuron mislocalised , abnormal
Show

 ZFA:0009115 skeletal muscle cell skeletal muscle cell Z disc disorganized , abnormal
skeletal muscle cell A band disorganized , abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell myofibril structure , ameliorated
slow muscle cell myofibril damaged , abnormal
slow muscle cell myofibril damaged , exacerbated
Show

 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron morphology , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell decreased contractility , abnormal
cardiac muscle cell Z disc disorganized , abnormal
cardiac muscle cell A band disorganized , abnormal
cardiac muscle cell myofibril disorganized , abnormal
cardiac muscle cell myofibril decreased amount , abnormal
cardiac muscle cell myofibril decreased size , abnormal
cardiac muscle cell decreased thickness , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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