ENSMUSG00000020782


Mus musculus

Features
Gene ID: ENSMUSG00000020782
  
Biological name :Llgl2
  
Synonyms : Lethal(2) giant larvae protein homolog 2 / Llgl2 / Q3TJ91
  
Possible biological names infered from orthology : LLGL2, scribble cell polarity complex component / Q6P1M3
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E2
Gene start: 115824049
Gene end: 115855780
  
Corresponding Affymetrix probe sets: 10382625 (MoGene1.0st)   1423938_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133790
Ensembl peptide - ENSMUSP00000119675
Ensembl peptide - ENSMUSP00000133803
Ensembl peptide - ENSMUSP00000136054
Ensembl peptide - ENSMUSP00000099321
Ensembl peptide - ENSMUSP00000117649
Ensembl peptide - ENSMUSP00000118304
Ensembl peptide - ENSMUSP00000118344
NCBI entrez gene - 217325     See in Manteia.
MGI - MGI:1918843
RefSeq - XM_006533087
RefSeq - NM_001252532
RefSeq - NM_145438
RefSeq - XM_006533083
RefSeq - XM_006533084
RefSeq - XM_006533085
RefSeq - XM_006533086
RefSeq Peptide - NP_001239461
RefSeq Peptide - NP_663413
swissprot - B1ATA9
swissprot - F6X6X1
swissprot - G3UXR0
swissprot - G3UXS2
swissprot - J3QJU5
swissprot - Q3TJ91
swissprot - B1ATA8
swissprot - B1ATA7
Ensembl - ENSMUSG00000020782
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 llgl2ENSDARG00000023920Danio rerio
 LLGL2ENSGALG00000008057Gallus gallus
 LLGL2ENSG00000073350Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Llgl1 / Q80Y17 / Lethal(2) giant larvae protein homolog 1 / Q15334* / LLGL1, scribble cell polarity complex component*ENSMUSG0000002053654
Q8K400 / Stxbp5 / Syntaxin-binding protein 5 / Q5T5C0*ENSMUSG0000001979028
Q5DQR4 / Stxbp5l / Syntaxin-binding protein 5-like / Q9Y2K9*ENSMUSG0000002282927


Protein motifs (from Interpro)
Interpro ID Name
 IPR000664  Lethal(2) giant larvae protein
 IPR001680  WD40 repeat
 IPR013577  Lethal giant larvae homologue 2
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001890 placenta development IMP
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0016332 establishment or maintenance of polarity of embryonic epithelium IMP
 biological_processGO:0017157 regulation of exocytosis IBA
 biological_processGO:0032878 regulation of establishment or maintenance of cell polarity IEA
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0050708 regulation of protein secretion IBA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060670 branching involved in labyrinthine layer morphogenesis IMP
 biological_processGO:0060716 labyrinthine layer blood vessel development IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017137 Rab GTPase binding IBA
 molecular_functionGO:0030165 PDZ domain binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: H2-T3tm2.1(CAG-EGFP)Maoh/H2-T3tm2.1(CAG-EGFP)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H2-T3tm2.1(CAG-EGFP)Maoh/H2-T3tm2.1(CAG-EGFP)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004921 decreased placenta weight "reduction in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H2-T3tm2.1(CAG-EGFP)Maoh/H2-T3tm2.1(CAG-EGFP)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H2-T3tm2.1(CAG-EGFP)Maoh/H2-T3tm2.1(CAG-EGFP)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H2-T3tm2.1(CAG-EGFP)Maoh/H2-T3tm2.1(CAG-EGFP)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H2-T3tm2.1(CAG-EGFP)Maoh/H2-T3tm2.1(CAG-EGFP)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: H2-T3tm2.1(CAG-EGFP)Maoh/H2-T3tm2.1(CAG-EGFP)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011521 decreased placental labyrinth size "reduction in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
Show

Allelic Composition: H2-T3tm2.1(CAG-EGFP)Maoh/H2-T3tm2.1(CAG-EGFP)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011522 abnormal placental labyrinth villi morphology "any structural anomaly of the vascularized and branched structures arising from the rodent trophoblast-derived epithelium that allow an increase its surface area for the efficient exchange of nutrients and wastes between the maternal and fetal circulation" [PMID:16916377]
Show

Allelic Composition: H2-T3tm2.1(CAG-EGFP)Maoh/H2-T3tm2.1(CAG-EGFP)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011525 abnormal placenta intervillous maternal lacunae morphology "any structural anomaly of the spaces of the placenta occupied by maternal blood, into which the fetal labyrinth villi project" [MGI:csmith]
Show

Allelic Composition: H2-T3tm2.1(CAG-EGFP)Maoh/H2-T3tm2.1(CAG-EGFP)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011526 abnormal placenta fetal blood space morphology "any structural anomaly of the spaces of the placenta occupied by fetal blood, primarily within the fetal labyrinth villi" [MGI:csmith]
Show

Allelic Composition: H2-T3tm2.1(CAG-EGFP)Maoh/H2-T3tm2.1(CAG-EGFP)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011528 abnormal placental labyrinth villi branching morphogenesis "any anomaly in the process in which the branches of the fetal placental villi are generated and organized from the trophoblast-derived epithelium" [PMID:16916377]
Show

Allelic Composition: H2-T3tm2.1(CAG-EGFP)Maoh/H2-T3tm2.1(CAG-EGFP)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011529 increased placenta intervillous maternal lacunae size "increased size of the spaces of the placenta occupied by maternal blood, into which the fetal labyrinth villi project" [MGI:csmith]
Show

Allelic Composition: H2-T3tm2.1(CAG-EGFP)Maoh/H2-T3tm2.1(CAG-EGFP)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr