ENSDARG00000023920


Danio rerio

Features
Gene ID: ENSDARG00000023920
  
Biological name :llgl2
  
Synonyms : lethal giant larvae homolog 2 (Drosophila) / llgl2 / Q7SZE3
  
Possible biological names infered from orthology : Lethal(2) giant larvae protein homolog 2 / LLGL2, scribble cell polarity complex component / Q3TJ91 / Q6P1M3
  
Species: Danio rerio
  
Chr. number: 12
Strand: -1
Band:
Gene start: 33734849
Gene end: 33789218
  
Corresponding Affymetrix probe sets: Dr.3566.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000148623
Ensembl peptide - ENSDARP00000148707
Ensembl peptide - ENSDARP00000035593
Ensembl peptide - ENSDARP00000105110
NCBI entrez gene - 795670     See in Manteia.
RefSeq - NM_212582
RefSeq Peptide - NP_997747
swissprot - B7ZVM2
swissprot - G1K2W2
swissprot - Q7SZE3
ZFIN ID - ZDB-GENE-030131-9877
Ensembl - ENSDARG00000023920
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LLGL2ENSGALG00000008057Gallus gallus
 LLGL2ENSG00000073350Homo sapiens
 Llgl2ENSMUSG00000020782Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
stxbp5a / syntaxin binding protein 5a (tomosyn) / STXBP5* / Q5T5C0* / Q8K400* / syntaxin binding protein 5*ENSDARG0000000265628
stxbp5b / syntaxin binding protein 5b (tomosyn) / Q5T5C0* / STXBP5* / syntaxin binding protein 5*ENSDARG0000002923427
Q5SQE2 / stxbp5l / syntaxin binding protein 5-like / Q5DQR4* / Q9Y2K9*ENSDARG0000000638327
llgl1 / lethal giant larvae homolog 1 (Drosophila) / Q15334* / Q80Y17* / Lethal(2) giant larvae protein homolog 1 * / LLGL1, scribble cell polarity complex component*ENSDARG0000000969315


Protein motifs (from Interpro)
Interpro ID Name
 IPR000664  Lethal(2) giant larvae protein
 IPR001680  WD40 repeat
 IPR013577  Lethal giant larvae homologue 2
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0007010 cytoskeleton organization IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0008544 epidermis development IMP
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0017157 regulation of exocytosis IBA
 biological_processGO:0030031 cell projection assembly IMP
 biological_processGO:0030336 negative regulation of cell migration IMP
 biological_processGO:0031581 hemidesmosome assembly IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043588 skin development IMP
 biological_processGO:0044458 motile cilium assembly IMP
 biological_processGO:0045682 regulation of epidermis development IGI
 biological_processGO:0048919 posterior lateral line neuromast development IMP
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IMP
 biological_processGO:0050708 regulation of protein secretion IBA
 biological_processGO:0070121 Kupffer"s vesicle development IMP
 biological_processGO:0098773 skin epidermis development IGI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IBA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0017137 Rab GTPase binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle has fewer parts of type Kupffers vesicle motile cilium, abnormal
Kupffers vesicle decreased area , abnormal
Kupffers vesicle motile cilium decreased length , abnormal
Kupffers vesicle basolateral plasma membrane physical object quality , abnormal
Kupffers vesicle decreased volume , abnormal
Kupffers vesicle motile cilium assembly decreased process quality , abnormal
Show

 ZFA:0000008 brain brain hydrocephalic , abnormal
brain spatial pattern , abnormal
brain right side mislocalised , abnormal
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 ZFA:0000051 otic vesicle otic vesicle decreased volume , abnormal
otic vesicle has fewer parts of type otic vesicle motile cilium, abnormal
otic vesicle motile cilium decreased length , abnormal
otic vesicle motile cilium assembly decreased process quality , abnormal
Show

 ZFA:0000105 epidermis epidermis quality , abnormal
epidermis malformed , abnormal
epidermis morphology , abnormal
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 ZFA:0000114 heart heart symmetry , abnormal
Show

 ZFA:0000121 lateral plate mesoderm lateral plate mesoderm bilateral symmetry , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct motile cilium decreased length , abnormal
pronephric duct motile cilium disorganized , abnormal
Show

 ZFA:0000292 surface structure surface structure quality , abnormal
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 ZFA:0000368 integument integument quality , abnormal
integument cell circular , abnormal
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 ZFA:0001069 ventral fin fold ventral fin fold malformed , abnormal
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 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism dead , abnormal
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 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
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 ZFA:0009034 epithelial cell epithelial cell increased amount , abnormal
epithelial cell lamellipodium increased amount , abnormal
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 ZFA:0009041 peridermal cell peridermal cell apical side decreased amount , abnormal
peridermal cell basal region decreased amount , abnormal
peridermal cell basal region has fewer parts of type peridermal cell filamentous actin, abnormal
peridermal cell actin-based cell projection decreased length , abnormal
peridermal cell actin-based cell projection decreased amount , abnormal
peridermal cell actin-based cell projection length , ameliorated
Show

 ZFA:0009183 epidermal cell epidermal cell morphology , abnormal
epidermal cell aggregated , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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