ENSDARG00000009693


Danio rerio

Features
Gene ID: ENSDARG00000009693
  
Biological name :llgl1
  
Synonyms : lethal giant larvae homolog 1 (Drosophila) / llgl1
  
Possible biological names infered from orthology : Lethal(2) giant larvae protein homolog 1 / LLGL1, scribble cell polarity complex component / Q15334 / Q80Y17
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 39970355
Gene end: 40054749
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000024810
Ensembl peptide - ENSDARP00000093316
Ensembl peptide - ENSDARP00000114914
Ensembl peptide - ENSDARP00000117251
NCBI entrez gene - 751760     See in Manteia.
RefSeq - NM_001045469
RefSeq - XM_005164141
RefSeq - XM_005164142
RefSeq - XM_021471471
RefSeq Peptide - NP_001038934
swissprot - F1QPI4
swissprot - E7FD67
swissprot - E9QDL6
swissprot - Q0P470
ZFIN ID - ZDB-GENE-060825-69
Ensembl - ENSDARG00000009693
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LLGL1ENSGALG00000014408Gallus gallus
 LLGL1ENSG00000131899Homo sapiens
 Llgl1ENSMUSG00000020536Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
llgl2 / Q7SZE3 / lethal giant larvae homolog 2 (Drosophila) / Q3TJ91* / Q6P1M3* / Lethal(2) giant larvae protein homolog 2 * / LLGL2, scribble cell polarity complex component*ENSDARG0000002392050
stxbp5b / syntaxin binding protein 5b (tomosyn) / Q5T5C0* / STXBP5* / syntaxin binding protein 5*ENSDARG0000002923433
stxbp5a / syntaxin binding protein 5a (tomosyn) / STXBP5* / Q5T5C0* / Q8K400* / syntaxin binding protein 5*ENSDARG0000000265632
Q5SQE2 / stxbp5l / syntaxin binding protein 5-like / Q5DQR4* / Q9Y2K9*ENSDARG0000000638331


Protein motifs (from Interpro)
Interpro ID Name
 IPR000664  Lethal(2) giant larvae protein
 IPR001680  WD40 repeat
 IPR013577  Lethal giant larvae homologue 2
 IPR013905  Lethal giant larvae (Lgl)-like, C-terminal domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003407 neural retina development IMP
 biological_processGO:0008593 regulation of Notch signaling pathway IMP
 biological_processGO:0017157 regulation of exocytosis IBA
 biological_processGO:0030031 cell projection assembly IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0048919 posterior lateral line neuromast development IMP
 biological_processGO:0050708 regulation of protein secretion IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0017137 Rab GTPase binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye shape , abnormal
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 ZFA:0000109 forebrain forebrain decreased size , abnormal
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 ZFA:0001094 whole organism whole organism viability , abnormal
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 ZFA:0009041 peridermal cell peridermal cell apical side decreased amount , abnormal
peridermal cell actin-based cell projection decreased length , abnormal
peridermal cell actin-based cell projection decreased size , abnormal
peridermal cell actin-based cell projection decreased amount , abnormal
peridermal cell actin-based cell projection length , ameliorated
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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