ENSMUSG00000020536


Mus musculus

Features
Gene ID: ENSMUSG00000020536
  
Biological name :Llgl1
  
Synonyms : Lethal(2) giant larvae protein homolog 1 / Llgl1 / Q80Y17
  
Possible biological names infered from orthology : LLGL1, scribble cell polarity complex component / Q15334
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B2
Gene start: 60699723
Gene end: 60714186
  
Corresponding Affymetrix probe sets: 10376690 (MoGene1.0st)   1416621_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000060749
Ensembl peptide - ENSMUSP00000104359
NCBI entrez gene - 16897     See in Manteia.
MGI - MGI:102682
RefSeq - XM_006532355
RefSeq - NM_001159404
RefSeq - NM_001159405
RefSeq - NM_008502
RefSeq - XM_006532354
RefSeq Peptide - NP_001152877
RefSeq Peptide - NP_032528
RefSeq Peptide - NP_001152876
swissprot - Q80Y17
swissprot - A0A0R4J0S4
Ensembl - ENSMUSG00000020536
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 llgl1ENSDARG00000009693Danio rerio
 LLGL1ENSGALG00000014408Gallus gallus
 LLGL1ENSG00000131899Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Llgl2 / Q3TJ91 / Lethal(2) giant larvae protein homolog 2 / Q6P1M3* / LLGL2, scribble cell polarity complex component*ENSMUSG0000002078254
Q8K400 / Stxbp5 / Syntaxin-binding protein 5 / Q5T5C0*ENSMUSG0000001979027
Q5DQR4 / Stxbp5l / Syntaxin-binding protein 5-like / Q9Y2K9*ENSMUSG0000002282926


Protein motifs (from Interpro)
Interpro ID Name
 IPR000664  Lethal(2) giant larvae protein
 IPR001680  WD40 repeat
 IPR013577  Lethal giant larvae homologue 2
 IPR013905  Lethal giant larvae (Lgl)-like, C-terminal domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006893 Golgi to plasma membrane transport ISS
 biological_processGO:0007409 axonogenesis ISS
 biological_processGO:0007420 brain development TAS
 biological_processGO:0017157 regulation of exocytosis IBA
 biological_processGO:0030866 cortical actin cytoskeleton organization ISO
 biological_processGO:0035090 maintenance of apical/basal cell polarity IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0050708 regulation of protein secretion IBA
 biological_processGO:0065003 protein-containing complex assembly IEA
 cellular_componentGO:0000137 Golgi cis cisterna ISS
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0030864 cortical actin cytoskeleton ISO
 cellular_componentGO:0031901 early endosome membrane ISS
 cellular_componentGO:0032588 trans-Golgi network membrane ISS
 cellular_componentGO:0035748 myelin sheath abaxonal region IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017137 Rab GTPase binding IBA
 molecular_functionGO:0019901 protein kinase binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000440 domed skull 
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J

 MP:0000786 abnormal neuroepithelial layer differentiation "malformation or arrest of differentiation or patterning of the epithelial layer of the brain" [J:45302]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J

 MP:0001917 intraventricular hemorrhage "bleeding into the brain ventricles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J

 MP:0004980 increased neuronal precursor cell number "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J

 MP:0012676 dilated brain ventricles "the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord is increased in volume or area, usually with an increase in contained fluid" [MGI:anna]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Llgl1tm1Vv/Llgl1tm1Vv,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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