ENSMUSG00000022829


Mus musculus

Features
Gene ID: ENSMUSG00000022829
  
Biological name :Stxbp5l
  
Synonyms : Q5DQR4 / Stxbp5l / Syntaxin-binding protein 5-like
  
Possible biological names infered from orthology : Q9Y2K9
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B3
Gene start: 37114942
Gene end: 37384962
  
Corresponding Affymetrix probe sets: 10439362 (MoGene1.0st)   1444077_at (Mouse Genome 430 2.0 Array)   1445297_at (Mouse Genome 430 2.0 Array)   1447922_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110435
Ensembl peptide - ENSMUSP00000110423
Ensembl peptide - ENSMUSP00000110428
Ensembl peptide - ENSMUSP00000110429
Ensembl peptide - ENSMUSP00000023526
Ensembl peptide - ENSMUSP00000110430
NCBI entrez gene - 207227     See in Manteia.
MGI - MGI:2443815
RefSeq - XM_017316900
RefSeq - NM_001114611
RefSeq - NM_001114612
RefSeq - NM_001114613
RefSeq - NM_172440
RefSeq - XM_006521884
RefSeq - XM_006521885
RefSeq - XM_006521886
RefSeq - XM_011245849
RefSeq - XM_017316899
RefSeq Peptide - NP_001108084
RefSeq Peptide - NP_001108085
RefSeq Peptide - NP_766028
RefSeq Peptide - NP_001108083
swissprot - Q5DQR4
Ensembl - ENSMUSG00000022829
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5SQE2ENSDARG00000006383Danio rerio
 STXBP5LENSGALG00000032361Gallus gallus
 Q9Y2K9ENSG00000145087Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8K400 / Stxbp5 / Syntaxin-binding protein 5 / Q5T5C0*ENSMUSG0000001979063
Llgl2 / Q3TJ91 / Lethal(2) giant larvae protein homolog 2 / Q6P1M3* / LLGL2, scribble cell polarity complex component*ENSMUSG0000002078224
Llgl1 / Q80Y17 / Lethal(2) giant larvae protein homolog 1 / Q15334* / LLGL1, scribble cell polarity complex component*ENSMUSG0000002053623


Protein motifs (from Interpro)
Interpro ID Name
 IPR000664  Lethal(2) giant larvae protein
 IPR001388  Synaptobrevin
 IPR001680  WD40 repeat
 IPR013577  Lethal giant larvae homologue 2
 IPR013905  Lethal giant larvae (Lgl)-like, C-terminal domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0017157 regulation of exocytosis IDA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046676 negative regulation of insulin secretion IDA
 biological_processGO:0050714 positive regulation of protein secretion IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017137 Rab GTPase binding IBA
 molecular_functionGO:0019905 syntaxin binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob,Stxbp5lT2dm1/Stxbp5lT2dm1,T2dm2C57BL/6J/T2dm2C57BL/6J
Genetic Background: involves: BTBR * C57BL/6J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Myd88tm1Defr/Myd88tm1Defr,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1l+
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Lepob/Lepob,Stxbp5lT2dm1/Stxbp5lT2dm1
Genetic Background: B6.Cg-Lepob Chr 16BTNTTF

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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