ENSMUSG00000019790


Mus musculus

Features
Gene ID: ENSMUSG00000019790
  
Biological name :Stxbp5
  
Synonyms : Q8K400 / Stxbp5 / Syntaxin-binding protein 5
  
Possible biological names infered from orthology : Q5T5C0
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: A1
Gene start: 9755547
Gene end: 9901079
  
Corresponding Affymetrix probe sets: 10367775 (MoGene1.0st)   1430301_at (Mouse Genome 430 2.0 Array)   1435398_at (Mouse Genome 430 2.0 Array)   1453021_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123355
Ensembl peptide - ENSMUSP00000044535
Ensembl peptide - ENSMUSP00000121507
Ensembl peptide - ENSMUSP00000123253
NCBI entrez gene - 78808     See in Manteia.
MGI - MGI:1926058
RefSeq - XM_011243238
RefSeq - XM_006512926
RefSeq - XM_006512927
RefSeq - XM_006512928
RefSeq - XM_011243236
RefSeq - XM_011243237
RefSeq - NM_001081344
RefSeq Peptide - NP_001074813
swissprot - F6WXQ4
swissprot - D3Z2Q2
swissprot - D3Z079
swissprot - Q8K400
Ensembl - ENSMUSG00000019790
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stxbp5aENSDARG00000002656Danio rerio
 stxbp5bENSDARG00000029234Danio rerio
 STXBP5ENSGALG00000012336Gallus gallus
 Q5T5C0ENSG00000164506Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5DQR4 / Stxbp5l / Syntaxin-binding protein 5-like / Q9Y2K9*ENSMUSG0000002282967
Llgl2 / Q3TJ91 / Lethal(2) giant larvae protein homolog 2 / Q6P1M3* / LLGL2, scribble cell polarity complex component*ENSMUSG0000002078226
Llgl1 / Q80Y17 / Lethal(2) giant larvae protein homolog 1 / Q15334* / LLGL1, scribble cell polarity complex component*ENSMUSG0000002053625


Protein motifs (from Interpro)
Interpro ID Name
 IPR000664  Lethal(2) giant larvae protein
 IPR001388  Synaptobrevin
 IPR001680  WD40 repeat
 IPR013577  Lethal giant larvae homologue 2
 IPR013905  Lethal giant larvae (Lgl)-like, C-terminal domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IDA
 biological_processGO:0007409 axonogenesis TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0017157 regulation of exocytosis IDA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045921 positive regulation of exocytosis IDA
 biological_processGO:0050708 regulation of protein secretion IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005892 acetylcholine-gated channel complex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030141 secretory granule NAS
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017075 syntaxin-1 binding IEA
 molecular_functionGO:0017137 Rab GTPase binding IBA
 molecular_functionGO:0019905 syntaxin binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Ldo/Trp53+
Genetic Background: B6.129S7-Trp53tm1Ldo

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Trp53tm1Ldo/Trp53+
Genetic Background: B6.129S7-Trp53tm1Ldo

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Trp53tm1Ldo/Trp53+
Genetic Background: B6.129S7-Trp53tm1Ldo

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1Ldo/Trp53+
Genetic Background: B6.129S7-Trp53tm1Ldo

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Trp53tm1Ldo/Trp53+
Genetic Background: B6.129S7-Trp53tm1Ldo

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Trp53tm1Ldo/Trp53+
Genetic Background: B6.129S7-Trp53tm1Ldo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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