ENSMUSG00000020805


Mus musculus

Features
Gene ID: ENSMUSG00000020805
  
Biological name :Slc13a5
  
Synonyms : Q67BT3 / Slc13a5 / Solute carrier family 13 member 5
  
Possible biological names infered from orthology : Q86YT5
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B4
Gene start: 72241989
Gene end: 72267222
  
Corresponding Affymetrix probe sets: 10388160 (MoGene1.0st)   1435936_at (Mouse Genome 430 2.0 Array)   1459729_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021161
Ensembl peptide - ENSMUSP00000119822
Ensembl peptide - ENSMUSP00000146762
Ensembl peptide - ENSMUSP00000146922
Ensembl peptide - ENSMUSP00000119417
NCBI entrez gene - 237831     See in Manteia.
MGI - MGI:3037150
RefSeq - XM_017314528
RefSeq - NM_001004148
RefSeq - XM_006533221
RefSeq - XM_017314526
RefSeq - XM_017314527
RefSeq Peptide - NP_001004148
swissprot - Q5NBV1
swissprot - Q67BT3
swissprot - A0A140LIR1
swissprot - A0A140LIC4
swissprot - Q5NBV0
Ensembl - ENSMUSG00000020805
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc13a5aENSDARG00000077691Danio rerio
 slc13a5bENSDARG00000039999Danio rerio
 SLC13A5ENSGALG00000005995Gallus gallus
 Q86YT5ENSG00000141485Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9ES88 / Slc13a2 / Solute carrier family 13 member 2 / Q13183*ENSMUSG0000000109550
Q91Y63 / Slc13a3 / solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 / Q8WWT9* / solute carrier family 13 member 3*ENSMUSG0000001845945
Slc13a4 / solute carrier family 13 member 4 / Q9UKG4*ENSMUSG0000002984341
Q9JHI4 / Slc13a1 / Solute carrier family 13 member 1 / Q9BZW2*ENSMUSG0000002970041


Protein motifs (from Interpro)
Interpro ID Name
 IPR001898  Solute carrier family 13
 IPR031312  Sodium/sulphate symporter, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006842 tricarboxylic acid transport IDA
 biological_processGO:0015744 succinate transport IDA
 biological_processGO:0015746 citrate transport IEA
 biological_processGO:0035674 tricarboxylic acid transmembrane transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071422 succinate transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0015137 citrate transmembrane transporter activity IDA
 molecular_functionGO:0015141 succinate transmembrane transporter activity IDA
 molecular_functionGO:0015142 tricarboxylic acid transmembrane transporter activity IDA
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0017153 sodium:dicarboxylate symporter activity IBA


Pathways (from Reactome)
Pathway description
Sodium-coupled sulphate, di- and tri-carboxylate transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

Allelic Composition: Slc13a5tm1.2Helf/Slc13a5+
Genetic Background: B6.Cg-Slc13a5tm1.2Helf

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

Allelic Composition: Slc13a5tm1.2Helf/Slc13a5+
Genetic Background: B6.Cg-Slc13a5tm1.2Helf

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

Allelic Composition: Slc13a5tm1.2Helf/Slc13a5+
Genetic Background: B6.Cg-Slc13a5tm1.2Helf

Allelic Composition: Slc13a5M1Btlr/Slc13a5M1Btlr
Genetic Background: C57BL/6J-Slc13a5M1Btlr

Allelic Composition: Slc13a5M1Btlr/Slc13a5+
Genetic Background: C57BL/6J-Slc13a5M1Btlr

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0003213 resistance to age related obesity "reduced probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0003439 abnormal glycerol level "anomalous concentration of this molecule, the backbone of lipids, which is important for gluconeogenesis during starvation" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95278]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0008963 increased carbon dioxide production "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0011117 abnormal susceptibility to weight gain "anomaly in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0013404 decreased circulating lactate level "reduced amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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