ENSMUSG00000020953


Mus musculus

Features
Gene ID: ENSMUSG00000020953
  
Biological name :Coch
  
Synonyms : Coch / Cochlin / Q62507
  
Possible biological names infered from orthology : O43405
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: B3
Gene start: 51593341
Gene end: 51605771
  
Corresponding Affymetrix probe sets: 10395659 (MoGene1.0st)   1423285_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000082533
Ensembl peptide - ENSMUSP00000128127
NCBI entrez gene - 12810     See in Manteia.
MGI - MGI:1278313
RefSeq - XM_017314944
RefSeq - NM_001198835
RefSeq - NM_007728
RefSeq - XM_017314943
RefSeq Peptide - NP_001185764
RefSeq Peptide - NP_031754
swissprot - Q62507
Ensembl - ENSMUSG00000020953
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cochENSDARG00000024032Danio rerio
 COCHENSGALG00000009920Gallus gallus
 COCHENSG00000100473Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vit / Q8VHI5 / vitrin / Q6UXI7*ENSMUSG0000002407642
A2AX52 / Col6a4 / Collagen alpha-4(VI) chain ENSMUSG0000003257223
Col6a5 / collagen type VI alpha 5 chain / A8TX70*ENSMUSG0000009134522
Col6a6 / Q8C6K9 / Collagen alpha-6(VI) chain / A6NMZ7* / collagen type VI alpha 6 chain*ENSMUSG0000004371922
Col6a3 / collagen, type VI, alpha 3 / P12111* / collagen type VI alpha 3 chain*ENSMUSG0000004812619
Q60847 / Col12a1 / Collagen alpha-1(XII) chain / Q99715* / collagen type XII alpha 1 chain*ENSMUSG0000003233217
Q80X19 / Col14a1 / Collagen alpha-1(XIV) chain / Q05707* / collagen type XIV alpha 1 chain*ENSMUSG0000002237115
Col7a1 / Q63870 / Collagen alpha-1(VII) chain / Q02388* / collagen type VII alpha 1 chain*ENSMUSG0000002565011
Vwa2 / Q70UZ7 / von Willebrand factor A domain containing 2 / Q5GFL6*ENSMUSG0000002508211
Q923P0 / Col20a1 / Collagen alpha-1(XX) chain / Q9P218* / collagen type XX alpha 1 chain*ENSMUSG000000163564


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR004043  LCCL domain
 IPR030743  Cochlin
 IPR036465  von Willebrand factor A-like domain superfamily
 IPR036609  LCCL domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0008360 regulation of cell shape ISO
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0045089 positive regulation of innate immune response IMP
 cellular_componentGO:0005576 extracellular region IMP
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt27stpm/Krt27stpm
Genetic Background: RHJ/LeJ-Krt27stpm/GrsrJ

Allelic Composition: Cochtm1Stw/Cochtm1Stw,Tmem163Tg(ACTB-cre)2Mrt/?
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Ldo/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004814 reduced linear vestibular evoked potential "reduction of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1Ldo/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cochtm1.1Stw/Cochtm1.1Stw
Genetic Background: CBA/Ca.129S1-Cochtm1.1Stw

Allelic Composition: Cochtm1.1Stw/Coch+
Genetic Background: CBA/Ca.129S1-Cochtm1.1Stw

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Trp53tm1Ldo/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cochtm1Mrtn/Coch+
Genetic Background: CBA/Ca.129S4-Cochtm1Mrtn

Allelic Composition: Cochtm1.1Stw/Cochtm1.1Stw
Genetic Background: CBA/Ca.129S1-Cochtm1.1Stw

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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