ENSMUSG00000022371


Mus musculus

Features
Gene ID: ENSMUSG00000022371
  
Biological name :Col14a1
  
Synonyms : Col14a1 / Collagen alpha-1(XIV) chain / Q80X19
  
Possible biological names infered from orthology : collagen type XIV alpha 1 chain / Q05707
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: D1
Gene start: 55307750
Gene end: 55520803
  
Corresponding Affymetrix probe sets: 10424140 (MoGene1.0st)   1427168_a_at (Mouse Genome 430 2.0 Array)   1428455_at (Mouse Genome 430 2.0 Array)   1453931_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023053
Ensembl peptide - ENSMUSP00000105846
Ensembl peptide - ENSMUSP00000105850
Ensembl peptide - ENSMUSP00000122455
NCBI entrez gene - 12818     See in Manteia.
MGI - MGI:1341272
RefSeq - XM_006520385
RefSeq - NM_181277
RefSeq - XM_006520384
RefSeq Peptide - NP_851794
swissprot - B7ZNH7
swissprot - Q80X19
swissprot - K3W4R4
swissprot - F7D5Y4
Ensembl - ENSMUSG00000022371
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 col14a1aENSDARG00000005762Danio rerio
 col14a1bENSDARG00000076623Danio rerio
 COL14A1ENSGALG00000037675Gallus gallus
 Q05707ENSG00000187955Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q60847 / Col12a1 / Collagen alpha-1(XII) chain / Q99715* / collagen type XII alpha 1 chain*ENSMUSG0000003233247
Col7a1 / Q63870 / Collagen alpha-1(VII) chain / Q02388* / collagen type VII alpha 1 chain*ENSMUSG0000002565028
Q923P0 / Col20a1 / Collagen alpha-1(XX) chain / Q9P218* / collagen type XX alpha 1 chain*ENSMUSG0000001635627
A2AX52 / Col6a4 / Collagen alpha-4(VI) chain ENSMUSG0000003257217
Col6a5 / collagen type VI alpha 5 chain / A8TX70*ENSMUSG0000009134517
Col6a6 / Q8C6K9 / Collagen alpha-6(VI) chain / A6NMZ7* / collagen type VI alpha 6 chain*ENSMUSG0000004371917
Col6a3 / collagen, type VI, alpha 3 / P12111* / collagen type VI alpha 3 chain*ENSMUSG0000004812616
Vwa2 / Q70UZ7 / von Willebrand factor A domain containing 2 / Q5GFL6*ENSMUSG0000002508210
Vit / Q8VHI5 / vitrin / Q6UXI7*ENSMUSG000000240766
Coch / Q62507 / Cochlin / O43405*ENSMUSG000000209535


Protein motifs (from Interpro)
Interpro ID Name
 IPR001791  Laminin G domain
 IPR002035  von Willebrand factor, type A
 IPR003961  Fibronectin type III
 IPR008160  Collagen triple helix repeat
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016133  Insect cysteine-rich antifreeze protein
 IPR036116  Fibronectin type III superfamily
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003229 ventricular cardiac muscle tissue development IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0030199 collagen fibril organization IMP
 biological_processGO:0048873 homeostasis of number of cells within a tissue IMP
 biological_processGO:0061050 regulation of cell growth involved in cardiac muscle cell development IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005614 interstitial matrix IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Collagen biosynthesis and modifying enzymes
Assembly of collagen fibrils and other multimeric structures
Collagen chain trimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rorbhstp/Rorbhstp
Genetic Background: C57BL/6J-Rorbhstp/J

 MP:0003089 reduced skin tensile strength "reduction in the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:48068]
Show

Allelic Composition: Rorbhstp/Rorbhstp
Genetic Background: C57BL/6J-Rorbhstp/J

 MP:0003098 reduced tendon stiffness "decreased ability of tendon to maintain tensile strength and load" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:79915]
Show

Allelic Composition: Rorbhstp/Rorbhstp
Genetic Background: C57BL/6J-Rorbhstp/J

Allelic Composition: Col14a1tm1Debi/Col14a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0005503 abnormal tendon morphology "structural anomaly of the fibrous bands or cords of connective tissue at the ends of muscle fibers that attach muscles to bones and other structures" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:45509]
Show

Allelic Composition: Rorbhstp/Rorbhstp
Genetic Background: C57BL/6J-Rorbhstp/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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