ENSG00000187955


Homo sapiens

Features
Gene ID: ENSG00000187955
  
Biological name :COL14A1
  
Synonyms : COL14A1 / collagen type XIV alpha 1 chain / Q05707
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q24.12
Gene start: 120059780
Gene end: 120372036
  
Corresponding Affymetrix probe sets: 212865_s_at (Human Genome U133 Plus 2.0 Array)   216865_at (Human Genome U133 Plus 2.0 Array)   216866_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428851
Ensembl peptide - ENSP00000429123
Ensembl peptide - ENSP00000443974
Ensembl peptide - ENSP00000247781
Ensembl peptide - ENSP00000297848
Ensembl peptide - ENSP00000311809
Ensembl peptide - ENSP00000403640
Ensembl peptide - ENSP00000409461
NCBI entrez gene - 7373     See in Manteia.
OMIM - 120324
RefSeq - NM_021110
RefSeq - XM_017013809
RefSeq - XM_006716651
RefSeq - XM_005251059
RefSeq Peptide - NP_066933
swissprot - A0A0A0MQT7
swissprot - Q05707
swissprot - Q4G0W3
swissprot - J3QT83
swissprot - J3QT75
swissprot - H0YBB2
Ensembl - ENSG00000187955
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 col14a1aENSDARG00000005762Danio rerio
 col14a1bENSDARG00000076623Danio rerio
 COL14A1ENSGALG00000037675Gallus gallus
 Q80X19ENSMUSG00000022371Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99715 / COL12A1 / collagen type XII alpha 1 chainENSG0000011179947
COL7A1 / Q02388 / collagen type VII alpha 1 chainENSG0000011427029
Q9P218 / COL20A1 / collagen type XX alpha 1 chainENSG0000010120327
COL6A3 / P12111 / collagen type VI alpha 3 chainENSG0000016335920
A8TX70 / COL6A5 / collagen type VI alpha 5 chainENSG0000017275218
A6NMZ7 / COL6A6 / collagen type VI alpha 6 chainENSG0000020638417
VWA2 / Q5GFL6 / von Willebrand factor A domain containing 2ENSG0000016581610
VIT / Q6UXI7 / vitrinENSG000002052216
COCH / O43405 / cochlinENSG000001004735


Protein motifs (from Interpro)
Interpro ID Name
 IPR001791  Laminin G domain
 IPR002035  von Willebrand factor, type A
 IPR003961  Fibronectin type III
 IPR008160  Collagen triple helix repeat
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016133  Insect cysteine-rich antifreeze protein
 IPR036116  Fibronectin type III superfamily
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0030198 extracellular matrix organization NAS
 biological_processGO:0030199 collagen fibril organization NAS
 biological_processGO:0098609 cell-cell adhesion NAS
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005581 collagen trimer NAS
 cellular_componentGO:0005596 collagen type XIV trimer NAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0031012 extracellular matrix ISS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005201 extracellular matrix structural constituent NAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005518 collagen binding NAS
 molecular_functionGO:0030674 protein binding, bridging NAS


Pathways (from Reactome)
Pathway description
Collagen degradation
Collagen biosynthesis and modifying enzymes
Assembly of collagen fibrils and other multimeric structures
Collagen chain trimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000982 Palmoplantar keratoderma 
Show

 HP:0001597 Abnormality of the nails "Abnormality of the fingernails or toenails." [HPO:curators]
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 HP:0002894 Pancreatic cancer 
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 HP:0003002 Breast cancer 
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 HP:0003003 Colon cancer 
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 HP:0005584 Renal cell carcinoma "Renal cell carcinoma (also known as hypernephroma) is the most common form of kidney cancer arising from the proximal renal tubule. The tissue of origin for renal cell carcinoma is the proximal renal tubular epithelium. Renal cell carcinoma can be classified as 1) clear cell carcinoma, 2) papillary carcinoma, 3) chromophobe renal carcinoma, and 4) collecting duct carcinoma." [HPO:curators]
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 HP:0006740 Transitional cell carcinoma of the bladder 
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 HP:0012189 Hodgkin s lymphoma "A typer of lymphoma characterized microscopically by multinucleated Reed-Sternberg cells." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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