ENSMUSG00000021468


Mus musculus

Features
Gene ID: ENSMUSG00000021468
  
Biological name :Sptlc1
  
Synonyms : O35704 / Serine palmitoyltransferase 1 / Sptlc1
  
Possible biological names infered from orthology : O15269 / serine palmitoyltransferase long chain base subunit 1
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B1
Gene start: 53332748
Gene end: 53377397
  
Corresponding Affymetrix probe sets: 10409294 (MoGene1.0st)   1422690_at (Mouse Genome 430 2.0 Array)   1422691_at (Mouse Genome 430 2.0 Array)   1436726_s_at (Mouse Genome 430 2.0 Array)   1436727_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021920
NCBI entrez gene - 268656     See in Manteia.
MGI - MGI:1099431
RefSeq - NM_009269
RefSeq Peptide - NP_033295
swissprot - O35704
Ensembl - ENSMUSG00000021468
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sptlc1ENSDARG00000042995Danio rerio
 SPTLC1ENSGALG00000013493Gallus gallus
 O15269ENSG00000090054Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004839  Aminotransferase, class I/classII
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006665 sphingolipid metabolic process IEA
 biological_processGO:0006686 sphingomyelin biosynthetic process ISA
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0030148 sphingolipid biosynthetic process IEA
 biological_processGO:0046511 sphinganine biosynthetic process IMP
 biological_processGO:0046512 sphingosine biosynthetic process IMP
 biological_processGO:0046513 ceramide biosynthetic process IEA
 biological_processGO:1904504 positive regulation of lipophagy IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0017059 serine C-palmitoyltransferase complex IEA
 cellular_componentGO:0035339 SPOTS complex IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004758 serine C-palmitoyltransferase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr1i2tm1(NR1I2)Arte/Nr1i2tm1(NR1I2)Arte,Nr1i3tm1.1Arte/Nr1i3tm1.1Arte
Genetic Background: involves: C57BL/6

 MP:0003949 abnormal circulating lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nr1i2tm1(NR1I2)Arte/Nr1i2tm1(NR1I2)Arte,Nr1i3tm1.1Arte/Nr1i3tm1.1Arte
Genetic Background: involves: C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nr1i2tm1(NR1I2)Arte/Nr1i2tm1(NR1I2)Arte,Nr1i3tm1.1Arte/Nr1i3tm1.1Arte
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000044408 Q8R207 / Sptssa / Serine palmitoyltransferase small subunit A / Q969W0*  / complex
 ENSMUSG00000043461 Q925E8 / Sptssb / Serine palmitoyltransferase small subunit B / Q8NFR3*  / complex
 ENSMUSG00000021036 P97363 / Sptlc2 / serine palmitoyltransferase, long chain base subunit 2 / O15270*  / complex
 ENSMUSG00000039092 Q8BG54 / Sptlc3 / Mus musculus serine palmitoyltransferase, long chain base subunit 3 (Sptlc3), transcript variant 1, mRNA. / Q9NUV7* / serine palmitoyltransferase long chain base subunit 3*  / complex






 

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