ENSMUSG00000044408


Mus musculus

Features
Gene ID: ENSMUSG00000044408
  
Biological name :Sptssa
  
Synonyms : Q8R207 / Serine palmitoyltransferase small subunit A / Sptssa
  
Possible biological names infered from orthology : Q969W0
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C1
Gene start: 54645392
Gene end: 54656573
  
Corresponding Affymetrix probe sets: 10400321 (MoGene1.0st)   1448388_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151214
Ensembl peptide - ENSMUSP00000053671
NCBI entrez gene - 104725     See in Manteia.
MGI - MGI:1913399
RefSeq - NM_134054
RefSeq Peptide - NP_598815
swissprot - A0A1W2P6D8
swissprot - Q8R207
Ensembl - ENSMUSG00000044408
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5BJC1ENSDARG00000071203Danio rerio
 SPTSSAENSGALG00000025755Gallus gallus
 Q969W0ENSG00000165389Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm6993 / Q969W0* / SPTSSA* / serine palmitoyltransferase small subunit A*ENSMUSG0000011218773
Q925E8 / Sptssb / Serine palmitoyltransferase small subunit B / Q8NFR3*ENSMUSG0000004346134


Protein motifs (from Interpro)
Interpro ID Name
 IPR024512  Small subunit of serine palmitoyltransferase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006665 sphingolipid metabolic process IEA
 biological_processGO:0046513 ceramide biosynthetic process ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0017059 serine C-palmitoyltransferase complex ISS
 molecular_functionGO:0004758 serine C-palmitoyltransferase activity ISS


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021468 O35704 / Sptlc1 / Serine palmitoyltransferase 1 / O15269* / serine palmitoyltransferase long chain base subunit 1*  / complex
 ENSMUSG00000021036 P97363 / Sptlc2 / serine palmitoyltransferase, long chain base subunit 2 / O15270*  / complex
 ENSMUSG00000039092 Q8BG54 / Sptlc3 / Mus musculus serine palmitoyltransferase, long chain base subunit 3 (Sptlc3), transcript variant 1, mRNA. / Q9NUV7* / serine palmitoyltransferase long chain base subunit 3*  / complex






 

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