ENSMUSG00000021565


Mus musculus

Features
Gene ID: ENSMUSG00000021565
  
Biological name :Slc6a19
  
Synonyms : Q9D687 / Slc6a19 / solute carrier family 6 (neurotransmitter transporter), member 19
  
Possible biological names infered from orthology : Q695T7 / solute carrier family 6 member 19
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: C1
Gene start: 73679745
Gene end: 73704865
  
Corresponding Affymetrix probe sets: 10410530 (MoGene1.0st)   1428595_at (Mouse Genome 430 2.0 Array)   1455442_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022048
Ensembl peptide - ENSMUSP00000119313
NCBI entrez gene - 74338     See in Manteia.
MGI - MGI:1921588
RefSeq - XM_006517419
RefSeq - NM_028878
RefSeq Peptide - NP_083154
swissprot - Q3KN89
swissprot - Q9D687
swissprot - D6RJ80
Ensembl - ENSMUSG00000021565
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc6a19a.1ENSDARG00000018621Danio rerio
 slc6a19a.2ENSDARG00000091560Danio rerio
 slc6a19bENSDARG00000056719Danio rerio
 SLC6A19ENSGALG00000019527Gallus gallus
 Q695T7ENSG00000174358Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O88576 / Slc6a18 / solute carrier family 6 (neurotransmitter transporter), member 18 / Q96N87* / solute carrier family 6 member 18*ENSMUSG0000002161251
O88575 / Slc6a20b / Sodium- and chloride-dependent transporter XTRP3B / Q9NP91* / SLC6A20* / solute carrier family 6 member 20*ENSMUSG0000002524344
Q8VDB9 / Slc6a20a / Sodium- and chloride-dependent transporter XTRP3A ENSMUSG0000003681444
Q8BG16 / Slc6a15 / Sodium-dependent neutral amino acid transporter B(0)AT2 / Q9H2J7* / solute carrier family 6 member 15*ENSMUSG0000001989442
Q8BJI1 / Slc6a17 / Sodium-dependent neutral amino acid transporter SLC6A17 / Q9H1V8* / solute carrier family 6 member 17*ENSMUSG0000002789441
Slc6a16 / Q9GZN6* / solute carrier family 6 member 16*ENSMUSG0000009415228
Slc6a21ENSMUSG0000007056812


Protein motifs (from Interpro)
Interpro ID Name
 IPR000175  Sodium:neurotransmitter symporter
 IPR002438  Sodium:neurotransmitter symporter, orphan
 IPR037272  Sodium:neurotransmitter symporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0006865 amino acid transport IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0015804 neutral amino acid transport IDA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031526 brush border membrane IDA
 molecular_functionGO:0005328 neurotransmitter:sodium symporter activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015175 neutral amino acid transmembrane transporter activity IDA
 molecular_functionGO:0015293 symporter activity IEA


Pathways (from Reactome)
Pathway description
Amino acid transport across the plasma membrane
Na+/Cl- dependent neurotransmitter transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Slc6a19tm1Dgen/Slc6a19tm1Dgen
Genetic Background: B6.129-Slc6a19tm1Dgen

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smcr8tm1.1(KOMP)Vlcg/Smcr8tm1.1(KOMP)Vlcg
Genetic Background: involves: 129S1/SvImJ * C57BL/6J * C57BL/6NTac

Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smcr8tm1.1(KOMP)Vlcg/Smcr8tm1.1(KOMP)Vlcg
Genetic Background: involves: 129S1/SvImJ * C57BL/6J * C57BL/6NTac

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smcr8tm1.1(KOMP)Vlcg/Smcr8tm1.1(KOMP)Vlcg
Genetic Background: involves: 129S1/SvImJ * C57BL/6J * C57BL/6NTac

Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003311 aminoaciduria "excretion of amino acids in the urine, especially in excessive amounts" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66560]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smcr8tm1.1(KOMP)Vlcg/Smcr8tm1.1(KOMP)Vlcg
Genetic Background: involves: 129S1/SvImJ * C57BL/6J * C57BL/6NTac

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Slc6a19tm1Dgen/Slc6a19+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011417 abnormal renal transport "any anomaly of the directed movement of substances through the kidney" [MGI:csmith]
Show

Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0020406 hyperthreoninuria "excretion of excessive amounts of threonine in the urine" [HP:0003296]
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Allelic Composition: Itgb1tm1Ross/Itgb1tm1Ross,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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