Manteia

ENSMUSG00000021612

Mus musculus

Features

Gene ID:	ENSMUSG00000021612

Biological name :	Slc6a18

Synonyms :	O88576 / Slc6a18 / solute carrier family 6 (neurotransmitter transporter), member 18

Possible biological names infered from orthology :	Q96N87 / solute carrier family 6 member 18

Species:	Mus musculus

Chr. number:	13
Strand:	-1
Band:	C1
Gene start:	73661752
Gene end:	73678023

Corresponding Affymetrix probe sets:	10410513 (MoGene1.0st) 1451879_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000152403 Ensembl peptide - ENSMUSP00000152697 Ensembl peptide - ENSMUSP00000152605 Ensembl peptide - ENSMUSP00000152525 Ensembl peptide - ENSMUSP00000152516 Ensembl peptide - ENSMUSP00000022105 Ensembl peptide - ENSMUSP00000105301 Ensembl peptide - ENSMUSP00000105302 Ensembl peptide - ENSMUSP00000152146 Ensembl peptide - ENSMUSP00000152273 NCBI entrez gene - 22598 See in Manteia. MGI - MGI:1336892 RefSeq - NM_001168644 RefSeq - NM_001168645 RefSeq - NM_001168643 RefSeq - NM_001040692 RefSeq - NM_001136087 RefSeq - NM_001168646 RefSeq Peptide - NP_001129559 RefSeq Peptide - NP_001162115 RefSeq Peptide - NP_001162116 RefSeq Peptide - NP_001162117 RefSeq Peptide - NP_001035782 RefSeq Peptide - NP_001162114 swissprot - O88576 swissprot - A0A1Y7VMA5 swissprot - A0A1Y7VJY3 swissprot - A0A1Y7VJ53 swissprot - A0A217FL56 Ensembl - ENSMUSG00000021612

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
slc6a18	ENSDARG00000068387	Danio rerio
SLC6A18	ENSGALG00000013180	Gallus gallus
Q96N87	ENSG00000164363	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q9D687 / Slc6a19 / solute carrier family 6 (neurotransmitter transporter), member 19 / Q695T7* / solute carrier family 6 member 19*	ENSMUSG00000021565	53
O88575 / Slc6a20b / Sodium- and chloride-dependent transporter XTRP3B / Q9NP91* / SLC6A20* / solute carrier family 6 member 20*	ENSMUSG00000025243	45
Q8VDB9 / Slc6a20a / Sodium- and chloride-dependent transporter XTRP3A	ENSMUSG00000036814	45
Q8BG16 / Slc6a15 / Sodium-dependent neutral amino acid transporter B(0)AT2 / Q9H2J7* / solute carrier family 6 member 15*	ENSMUSG00000019894	42
Q8BJI1 / Slc6a17 / Sodium-dependent neutral amino acid transporter SLC6A17 / Q9H1V8* / solute carrier family 6 member 17*	ENSMUSG00000027894	41
Slc6a16 / Q9GZN6* / solute carrier family 6 member 16*	ENSMUSG00000094152	28
Slc6a21	ENSMUSG00000070568	14

Protein motifs (from Interpro)

Interpro ID	Name
IPR000175	Sodium:neurotransmitter symporter
IPR002438	Sodium:neurotransmitter symporter, orphan
IPR037272	Sodium:neurotransmitter symporter superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0003333	amino acid transmembrane transport	IDA
biological_process	GO:0006836	neurotransmitter transport	IEA
biological_process	GO:0006865	amino acid transport	IEA
biological_process	GO:0015804	neutral amino acid transport	IEA
biological_process	GO:0055085	transmembrane transport	IEA
cellular_component	GO:0005886	plasma membrane	IDA
cellular_component	GO:0005887	integral component of plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0031526	brush border membrane	IDA
molecular_function	GO:0005215	transporter activity	TAS
molecular_function	GO:0005328	neurotransmitter:sodium symporter activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0015175	neutral amino acid transmembrane transporter activity	IMP
molecular_function	GO:0015293	symporter activity	IEA

Pathways (from Reactome)

Pathway description

Amino acid transport across the plasma membrane

Na+/Cl- dependent neurotransmitter transporters

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000231	hypertension	"sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Tmod1^tm1Sung/Tmod1^tm1Sung Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003311	aminoaciduria	"excretion of amino acids in the urine, especially in excessive amounts" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66560]	Show Allelic Composition: Tmod1^tm1Sung/Tmod1^tm1Sung Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0006144	increased systolic blood pressure	"abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Tmod1^tm1Sung/Tmod1^tm1Sung Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0010107	abnormal renal reabsorption	"any anomaly in the two-step process beginning with the active or passive extraction of substances (such as water, glucose, oligopeptides, amino acids, sodium (Na+) and other ions) from the renal tubule fluid into the renal interstitium, and the subsequent transport of these substances out of the renal interstitium back into the bloodstream; reabsorption begins in the proximal convoluted tubules and continues in the loop of Henle, distal convoluted tubules, and collecting tubules" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tmod1^tm1Sung/Tmod1^tm1Sung Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0011417	abnormal renal transport	"any anomaly of the directed movement of substances through the kidney" [MGI:csmith]	Show Allelic Composition: Tmod1^tm1Sung/Tmod1^tm1Sung Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr